Výsledky vyhledávání - "A. R. Van Der Slik"

Akademický článek

Diabetes risk loci-associated pathways are shared across metabolic tissues

Autor: Gerard A. Bouland, Joline W. J. Beulens, Joey Nap, Arno R. van der Slik, Arnaud Zaldumbide, Leen M. ’t Hart, Roderick C. Slieker

Publikováno v: BMC Genomics, Vol 23, Iss 1, Pp 1-9 (2022)

Abstract Aims/hypothesis Numerous genome-wide association studies have been performed to understand the influence of genetic variation on type 2 diabetes etiology. Many identified risk variants are located in non-coding and intergenic regions, which

Externí odkaz: https://doaj.org/article/3ad7c553e70d4b9ba2a38b7010f19527

Zobrazit plný text záznamu

Plný text ve formátu HTML

Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells

Autor: René van Tienhoven, Maria J. L. Kracht, Arno R. van der Slik, Sofia Thomaidou, Anouk H. G. Wolters, Ben N. G. Giepmans, Juan Pablo Romero Riojas, Michael S. Nelson, Françoise Carlotti, Eelco J. P. de Koning, Rob C. Hoeben, Arnaud Zaldumbide, Bart O. Roep

Publikováno v: Diabetologia, 66(5), 884-896. SPRINGER

Aims/hypothesis Transcriptome analyses revealed insulin-gene-derived transcripts in non-beta endocrine islet cells. We studied alternative splicing of human INS mRNA in pancreatic islets. Methods Alternative splicing of insulin pre-mRNA was determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d078ebd9b4dbdb4aa6a72a2035c08148
http://hdl.handle.net/1887/3619412

Zobrazit plný text záznamu

β-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1

Autor: Arnaud Zaldumbide, Françoise Carlotti, Bart O. Roep, Sandra Laban, Arno R. van der Slik, Maria J L Kracht, Rob C. Hoeben, Sofia Thomaidou, Eelco J.P. de Koning

Publikováno v: Diabetes
Diabetes, 69(4), 670-680. American Diabetes Association Inc.
Diabetes, 69(4), 670-680. AMER DIABETES ASSOC

The signal peptide of preproinsulin is a major source for HLA class I autoantigen epitopes implicated in CD8 T cell (CTL)-mediated beta -cell destruction in type 1 diabetes (T1D). Among them, the 10-mer epitope located at the C-terminal end of the si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216fb84e5b7d06674e51a14506910c76
https://doi.org/10.2337/db19-0984

Zobrazit plný text záznamu

Long-RNA Sequencing and Ribosome Profiling of Inflamed Beta-Cells Reveal an Extensive Translatome Landscape

Autor: Arnaud Zaldumbide, Hailiang Mei, Bart O. Roep, Rob C. Hoeben, Francoise Carlotti, Bobby Koeleman, Leen M. ‘t Hart, Amadeo Munoz-Garcia, Flip Mulder, Jasper Boom, Arno R. van der Slik, Roderick C. Slieker, Sofia Thomaidou

Type 1 diabetes is an autoimmune disease characterized by autoreactive T-cell mediated destruction of the insulin-producing pancreatic beta-cells. Increasing evidence suggest that the beta-cells themselves contribute to their own destruction by gener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14505a9c9c16ae166c3b8b04a0a2160e
https://doi.org/10.2337/figshare.14771181.v1

Zobrazit plný text záznamu

Akademický článek

Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.

Autor: Wendy W J Unger, Todd Pearson, Joana R F Abreu, Sandra Laban, Arno R van der Slik, Sacha Mulder-van der Kracht, Michel G D Kester, Dave V Serreze, Leonard D Shultz, Marieke Griffioen, Jan Wouter Drijfhout, Dale L Greiner, Bart O Roep

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e49213 (2012)

Despite increasing evidence that autoreactive CD8 T-cells are involved in both the initiation of type 1 diabetes (T1D) and the destruction of beta-cells, direct evidence for their destructive role in-vivo is lacking. To address a destructive role for

Externí odkaz: https://doaj.org/article/297b9f04854a44a28b087719b3a693fc

Zobrazit plný text záznamu

Differential transcriptome of tolerogenic versus inflammatory dendritic cells points to modulated T1D genetic risk and enriched immune regulation

Autor: Chantal Mathieu, A. R. Van Der Slik, Nicky J C Woittiez, Tanja Nikolic, Bart O. Roep, Antoinette M. Joosten, Sandra Laban, Conny Gysemans, Jaap-Jan Zwaginga, B. P. C. Koeleman

Publikováno v: Genes and Immunity, 18(3), 176-183

Tolerogenic dendritic cells (tolDCs) are assessed as immunomodulatory adjuvants to regulate autoimmunity. The underlying gene expression endorsing their regulatory features remains ill-defined. Using deep mRNA sequencing, we compared transcriptomes o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb55deb6b60a42dc58c00deebda537e
https://hdl.handle.net/1887/114851

Zobrazit plný text záznamu

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes

Autor: Arnaud Zaldumbide, Arno R. van der Slik, Menno van Lummel, Rob C. Hoeben, Sandra Laban, Peter A. van Veelen, Bart O. Roep, Eelco J.P. de Koning, Tatjana Nikolic, Maria J L Kracht, Antoinette M. Joosten, Françoise Carlotti

Publikováno v: Nature Medicine, 23(4), 501
Nature Medicine
Nature Medicine, 23(4), 501-507. Nature Publishing Group

Identification of epitopes that are recognized by diabetogenic T cells and cause selective beta cell destruction in type 1 diabetes (T1D) has focused on peptides originating from native beta cell proteins. Translational errors represent a major poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565ffdb74de3750268ff4811569c3b30
https://doi.org/10.1038/nm.4289

Zobrazit plný text záznamu

Survival of autoreactive T lymphocytes by microRNA-mediated regulation of apoptosis through TRAIL and Fas in type 1 diabetes

Autor: Arnaud Zaldumbide, V M de Jong, B. P. C. Koeleman, A. R. Van Der Slik, Bart O. Roep, R. van 't Slot, Sandra Laban

Publikováno v: Genes and Immunity, 17(6), 342-348

Autoreactive CD8(+) T cells recognizing autoantigens expressed by pancreatic islets lead to the destruction of insulin-producing beta cells in type 1 diabetes (T1D), but these T cells also occur in healthy subjects. We tested the hypothesis that unco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d058e058b7f4093954b13d85e3063a1
http://hdl.handle.net/1887/112082

Zobrazit plný text záznamu

Variation in the CTLA4 3 ' UTR has phenotypic consequences for autoreactive T cells and associates with genetic risk for type 1 diabetes

Autor: Sandra Laban, A. R. Van Der Slik, B. P. C. Koeleman, Bart O. Roep, V M de Jong, Arnaud Zaldumbide

Publikováno v: Genes and Immunity, 17(1), 75-78
Genes and Immunity, 17(1), 75-78. NATURE PUBLISHING GROUP

Cytotoxic T-lymphocyte-associated protein 4 (CTLA4) is a protein receptor that downregulates the immune system. CTLA4 gene variants associate with various autoimmune diseases, including type 1 diabetes. Fine mapping of the genetic risk has shown that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b0190fe9ab394547216bf7b5592207
https://hdl.handle.net/1887/99393

Zobrazit plný text záznamu

Induction of Treg by monocyte-derived DC modulated by vitamin D3or dexamethasone: Differential role for PD-L1

Autor: Arno R. van der Slik, Wendy W. J. Unger, Bart O. Roep, Fleur S. Kleijwegt, Sandra Laban

Publikováno v: European Journal of Immunology. 39:3147-3159

Specific therapy with modulated DC may restore immunological tolerance, thereby obviating the need for chronic immunosuppression in transplantation or autoimmunity. In this study we compared the tolerizing capacity of dexamethasone (Dex)- and 1 alpha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88141c73e45c7adf8b6b12bc66d2c37b
https://doi.org/10.1002/eji.200839103

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání