Zobrazeno 1 - 10
of 390
pro vyhledávání: '"A. R. Satoskar"'
Autor:
N. Fatima, N. Sheikh, A. R. Satoskar, T. Akhtar, A. Tayyeb, I. Ashfaq, N. Ryan, S. Ambreen, B. K. Jha, S. Oghumu
Publikováno v:
Mediators of Inflammation, Vol 2021 (2021)
Tacrolimus (TAC) is an immunosuppressive drug, optimally used for liver, kidney, and heart transplant to avoid immune rejection. In retrospect, a multitude of studies have reported effects of TAC, such as nephrotoxicity, diabetes, and other complicat
Externí odkaz:
https://doaj.org/article/7725187540014c53bd63a5a3882e4aa2
Autor:
Ranadhir Dey, Jalal Alshaweesh, Kamaleshwar P. Singh, Patrick Lypaczewski, Subir Karmakar, Laura Klenow, Kayla Paulini, Swarnendu Kaviraj, Shaden Kamhawi, Jesus G. Valenzuela, Sanjay Singh, Shinjiro Hamano, Abhay R. Satoskar, Sreenivas Gannavaram, Hira L. Nakhasi, Greg Matlashewski
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The leishmanin skin test was used for almost a century to detect exposure and immunity to Leishmania, the causative agent of leishmaniasis, a major neglected tropical disease. Due to a lack of antigen used for the intradermal injection, the
Externí odkaz:
https://doaj.org/article/11c3719514794468adb0c66ddc329d73
Autor:
Greta Volpedo, Timur Oljuskin, Blake Cox, Yulian Mercado, Candice Askwith, Nazli Azodi, Matthew Bernier, Hira L. Nakhasi, Sreenivas Gannavaram, Abhay R. Satoskar
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108502- (2023)
Summary: Cutaneous leishmaniasis (CL) is characterized by extensive skin lesions, which are usually painless despite being associated with extensive inflammation. The molecular mechanisms responsible for this analgesia have not been identified. Throu
Externí odkaz:
https://doaj.org/article/4bf860590ede4681a76816146cf835c2
Autor:
Bijay Kumar Jha, Sanjay Varikuti, Chaitenya Verma, Rahul Shivahare, Nicholas Bishop, Gregory P. Dos Santos, Jacquelyn McDonald, Aakash Sur, Peter J. Myler, Sergio Schenkman, Abhay R. Satoskar, Bradford S. McGwire
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-15 (2023)
Abstract Human infection with the protozoan parasite Trypanosoma cruzi causes Chagas disease for which there are no prophylactic vaccines. Cyclophilin 19 is a secreted cis-trans peptidyl isomerase expressed in all life stages of Trypanosoma cruzi. Th
Externí odkaz:
https://doaj.org/article/1367d015c44242d79c6a96b086f14752
Autor:
Konstantinos Karagiannis, Sreenivas Gannavaram, Chaitenya Verma, Thalia Pacheco-Fernandez, Parna Bhattacharya, Hira L. Nakhasi, Abhay R. Satoskar
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113097- (2023)
Summary: Although phagocytic cells are documented targets of Leishmania parasites, it is unclear whether other cell types can be infected. Here, we use unbiased single-cell RNA sequencing (scRNA-seq) to simultaneously analyze host cell and Leishmania
Externí odkaz:
https://doaj.org/article/9b1ee9ec4bf04ba89c4a87f600095aeb
Autor:
Subir Karmakar, Greta Volpedo, Wen-Wei Zhang, Patrick Lypaczewski, Nevien Ismail, Fabiano Oliveira, James Oristian, Claudio Meneses, Sreenivas Gannavaram, Shaden Kamhawi, Shinjiro Hamano, Jesus G. Valenzuela, Greg Matlashewski, Abhay R. Satoskar, Ranadhir Dey, Hira L. Nakhasi
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Leishmaniasis is one of the top neglected tropical diseases with significant morbidity and mortality in low and middle-income countries (LMIC). However, this disease is also spreading in the developed world. Currently, there is a lack of eff
Externí odkaz:
https://doaj.org/article/26413e213d76441788ba0d0d2b589f6a
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/3e9ce7ec6619497abcb119c42443e1e5
Autor:
Nevien Ismail, Subir Karmakar, Parna Bhattacharya, Telly Sepahpour, Kazuyo Takeda, Shinjiro Hamano, Greg Matlashewski, Abhay R. Satoskar, Sreenivas Gannavaram, Ranadhir Dey, Hira L. Nakhasi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Leishmaniasis is a vector-borne parasitic disease transmitted through the bite of a sand fly with no available vaccine for humans. Recently, we have developed a live attenuated Leishmania major centrin gene-deleted parasite strain (LmCen-/-) that ind
Externí odkaz:
https://doaj.org/article/d922fe69acf54257873a8b09ab04cc74
Autor:
Greta Volpedo, Thalia Pacheco-Fernandez, Parna Bhattacharya, Timur Oljuskin, Ranadhir Dey, Sreenivas Gannavaram, Abhay R. Satoskar, Hira L. Nakhasi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Leishmaniasis is endemic to the tropical and subtropical regions of the world and is transmitted by the bite of an infected sand fly. The multifaceted interactions between Leishmania, the host innate immune cells, and the adaptive immunity determine
Externí odkaz:
https://doaj.org/article/89a60892743549e0bee34f1222769691
Autor:
Greta Volpedo, Thalia Pacheco-Fernandez, Erin A. Holcomb, Natalie Cipriano, Blake Cox, Abhay R. Satoskar
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Leishmaniasis is a neglected tropical disease that affects 12 million people worldwide. The disease has high morbidity and mortality rates and is prevalent in over 80 countries, leaving more than 300 million people at risk of infection. Of all of the
Externí odkaz:
https://doaj.org/article/e77db1be3a724124aa555a619d64a72a