Zobrazeno 1 - 10
of 272
pro vyhledávání: '"A. R. Muotri"'
Autor:
G. Carola, D. Malagarriga, C. Calatayud, M. Pons-Espinal, L. Blasco-Agell, Y. Richaud-Patin, I. Fernandez-Carasa, V. Baruffi, S. Beltramone, E. Molina, P. Dell’Era, J. J. Toledo-Aral, E. Tolosa, A. R. Muotri, J. Garcia Ojalvo, J. Soriano, A. Raya, A. Consiglio
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-14 (2021)
Abstract A deeper understanding of early disease mechanisms occurring in Parkinson’s disease (PD) is needed to reveal restorative targets. Here we report that human induced pluripotent stem cell (iPSC)-derived dopaminergic neurons (DAn) obtained fr
Externí odkaz:
https://doaj.org/article/7c8c8c544c2b4347a40c5da25a5f23b4
Autor:
M. van der Vaart, O. Svoboda, B. G. Weijts, R. Espín-Palazón, V. Sapp, T. Pietri, M. Bagnat, A. R. Muotri, D. Traver
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 12, Pp 1439-1451 (2017)
Mutations in MECP2 cause Rett syndrome, a severe neurological disorder with autism-like features. Duplication of MECP2 also causes severe neuropathology. Both diseases display immunological abnormalities that suggest a role for MECP2 in controlling i
Externí odkaz:
https://doaj.org/article/1992b7c52c144e70a604cbe256da17d0
Autor:
Eric Courchesne, Vani Taluja, Sanaz Nazari, Caitlin M. Aamodt, Karen Pierce, Kuaikuai Duan, Sunny Stophaeros, Linda Lopez, Cynthia Carter Barnes, Jaden Troxel, Kathleen Campbell, Tianyun Wang, Kendra Hoekzema, Evan E. Eichler, Joao V. Nani, Wirla Pontes, Sandra Sanchez Sanchez, Michael V. Lombardo, Janaina S. de Souza, Mirian A. F. Hayashi, Alysson R. Muotri
Publikováno v:
Molecular Autism, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Background Social affective and communication symptoms are central to autism spectrum disorder (ASD), yet their severity differs across toddlers: Some toddlers with ASD display improving abilities across early ages and develop good social an
Externí odkaz:
https://doaj.org/article/428ca825209e4345a0da67a2ab8b0da8
Autor:
Hyeon‐Yeol Cho, Myungsik Yoo, Thanapat Pongkulapa, Hudifah Rabie, Alysson R. Muotri, Perry T. Yin, Jeong‐Woo Choi, Ki‐Bum Lee
Publikováno v:
Advanced Science, Vol 11, Iss 24, Pp n/a-n/a (2024)
Abstract The CRISPR‐Cas9 technology has the potential to revolutionize the treatment of various diseases, including Rett syndrome, by enabling the correction of genes or mutations in human patient cells. However, several challenges need to be addre
Externí odkaz:
https://doaj.org/article/7124b7eb05c34190b1e27d9c94807b25
Autor:
Jason W. Adams, Annabelle Vinokur, Janaína S. de Souza, Charles Austria, Bruno S. Guerra, Roberto H. Herai, Karl J. Wahlin, Alysson R. Muotri
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113867- (2024)
Summary: Individuals with Williams syndrome (WS), a neurodevelopmental disorder caused by hemizygous loss of 26–28 genes at 7q11.23, characteristically portray a hypersocial phenotype. Copy-number variations and mutations in one of these genes, GTF
Externí odkaz:
https://doaj.org/article/77e344c08eb6407895cdd8d2439e33a3
Autor:
Tianyi Chen, Youngser Park, Ali Saad-Eldin, Zachary Lubberts, Avanti Athreya, Benjamin D. Pedigo, Joshua T. Vogelstein, Francesca Puppo, Gabriel A. Silva, Alysson R. Muotri, Weiwei Yang, Christopher M. White, Carey E. Priebe
Publikováno v:
Applied Network Science, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract Recent advancements have been made in the development of cell-based in-vitro neuronal networks, or organoids. In order to better understand the network structure of these organoids, a super-selective algorithm has been proposed for inferring
Externí odkaz:
https://doaj.org/article/dd431d1a9d754a39a8e3c7919c7480ff
Autor:
Itzy E. Morales Pantoja, Lena Smirnova, Alysson R. Muotri, Karl J. Wahlin, Jeffrey Kahn, J. Lomax Boyd, David H. Gracias, Timothy D. Harris, Tzahi Cohen-Karni, Brian S. Caffo, Alexander S. Szalay, Fang Han, Donald J. Zack, Ralph Etienne-Cummings, Akwasi Akwaboah, July Carolina Romero, Dowlette-Mary Alam El Din, Jesse D. Plotkin, Barton L. Paulhamus, Erik C. Johnson, Frederic Gilbert, J. Lowry Curley, Ben Cappiello, Jens C. Schwamborn, Eric J. Hill, Paul Roach, Daniel Tornero, Caroline Krall, Rheinallt Parri, Fenna Sillé, Andre Levchenko, Rabih E. Jabbour, Brett J. Kagan, Cynthia A. Berlinicke, Qi Huang, Alexandra Maertens, Kathrin Herrmann, Katya Tsaioun, Raha Dastgheyb, Christa Whelan Habela, Joshua T. Vogelstein, Thomas Hartung
Publikováno v:
Frontiers in Artificial Intelligence, Vol 6 (2023)
The brain is arguably the most powerful computation system known. It is extremely efficient in processing large amounts of information and can discern signals from noise, adapt, and filter faulty information all while running on only 20 watts of powe
Externí odkaz:
https://doaj.org/article/aebc0f0cd878418ebed9205a612b1932
Autor:
Foluwasomi A Oyefeso, Gabriela Goldberg, Nana Yaa P S Opoku, Marcelo Vazquez, Antonella Bertucci, Zhong Chen, Charles Wang, Alysson R Muotri, Michael J Pecaut
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0282958 (2023)
Human exposure to low-to-moderate dose ionizing radiation (LMD-IR) is increasing via environmental, medical, occupational sources. Acute exposure to LMD-IR can cause subclinical damage to cells, resulting in altered gene expression and cellular funct
Externí odkaz:
https://doaj.org/article/fdd2d19a98bc4f9c95091abd53f6640a
Autor:
Alysson R. Muotri
Publikováno v:
Genetics and Molecular Biology, Vol 46, Iss 1 (2023)
Abstract LINE-1 (L1) elements are a class of transposons, comprising approximately 19% and 21% of the mouse and human genomes, respectively. L1 retrotransposons can reverse transcribe their own RNA sequence into a de novo DNA copy integrated into a n
Externí odkaz:
https://doaj.org/article/8b8c9d3f5f8342b39eb5750d35afdf52
Autor:
Sergiu P. Pașca, Paola Arlotta, Helen S. Bateup, J. Gray Camp, Silvia Cappello, Fred H. Gage, Jürgen A. Knoblich, Arnold R. Kriegstein, Madeline A. Lancaster, Guo-Li Ming, Alysson R. Muotri, In-Hyun Park, Orly Reiner, Hongjun Song, Lorenz Studer, Sally Temple, Giuseppe Testa, Barbara Treutlein, Flora M. Vaccarino
Publikováno v:
Nature. 609:907-910
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::319c87f1da7ef24366232a303aba30de
https://doi.org/10.1038/s41586-022-05219-6
https://doi.org/10.1038/s41586-022-05219-6