Zobrazeno 1 - 10
of 1 208
pro vyhledávání: '"A. R. Middleton"'
Autor:
Simei Go, Constantinos Demetriou, Giampiero Valenzano, Sophie Hughes, Simone Lanfredini, Helen Ferry, Edward Arbe-Barnes, Shivan Sivakumar, Rachel Bashford-Rogers, Mark R Middleton, Somnath Mukherjee, Jennifer Morton, Keaton Jones, Eric O Neill
Publikováno v:
eLife, Vol 13 (2024)
The immunosuppressive microenvironment in pancreatic ductal adenocarcinoma (PDAC) prevents tumor control and strategies to restore anti-cancer immunity (i.e. by increasing CD8 T-cell activity) have had limited success. Here, we demonstrate how induci
Externí odkaz:
https://doaj.org/article/71c5b8de40e04161b42d0234f53620ea
Autor:
Elena Elez, Antonio Cubillo, Pilar Garcia Alfonso, Mark R. Middleton, Ian Chau, Baha Alkuzweny, Ann Alcasid, Xiaosong Zhang, Eric Van Cutsem
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background In patients with previously treated RAS-mutated microsatellite-stable (MSS) metastatic colorectal cancer (mCRC), a multicenter open-label phase 1b/2 trial was conducted to define the safety and efficacy of the MEK1/MEK2 inhibitor
Externí odkaz:
https://doaj.org/article/df5ecc4526e845d49481ee6aa799d831
Autor:
R. Middleton, M. Sinnott-Armstrong
Publikováno v:
APL Photonics, Vol 9, Iss 8, Pp 081102-081102-11 (2024)
This Tutorial introduces structural color in fruits as a phenomenon of diverse optical materials. Originally best known in abiotic materials and animals, structural colors are being increasingly described in plants. Structural colors have already ins
Externí odkaz:
https://doaj.org/article/03e39697ce2c43d7b7d91004e59cc27c
Autor:
Brian Shine, Robert Pell, Weiyu Ye, Mark R Middleton, Tim James, Stephanie Jones, Robert A Watson, Ian S D Roberts, Monika Hofer, Damian Jenkins, Miranda J Payne, Nicholas Coupe, Chelsea A Taylor, Elsita Jungkurth, Rosalin Cooper, Orion Tong, Eleni Ieremia, David Maldonado-Perez, Benjamin P Fairfax
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
We describe three cases of critical acute myositis with myocarditis occurring within 22 days of each other at a single institution, all within 1 month of receiving the initial cycle of the anti-PD-1 drug pembrolizumab. Analysis of T cell receptor rep
Externí odkaz:
https://doaj.org/article/97a4f9e90ef947358cb17f5b1cd03194
Autor:
Allison A Appleton, Rebecca Rogers, Sarah McCarthy, Betty Lin, Rachel R Middleton, Bethlehem Terefe, Beth J Feingold, Tara Lynch, Alex L Pieterse, Annabelle E Armah, Lydia F Bierce, Amanda M Flagg
Publikováno v:
BMJ Open, Vol 14, Iss 4 (2024)
Introduction In the USA, Black birthing people and infants experience disproportionately worse pregnancy-related health outcomes. The causes for these disparities are unknown, but evidence suggests that they are likely socially and environmentally ba
Externí odkaz:
https://doaj.org/article/3a29342c8a2b41e9afa0508c6d3d983f
Autor:
Ellen de Jong, Kayley D. McCubbin, David Speksnijder, Simon Dufour, John R. Middleton, Pamela L. Ruegg, Theo J.G.M. Lam, David F. Kelton, Scott McDougall, Sandra M. Godden, Alfonso Lago, Päivi J. Rajala-Schultz, Karin Orsel, Sarne De Vliegher, Volker Krömker, Diego B. Nobrega, John P. Kastelic, Herman W. Barkema
Publikováno v:
Journal of Dairy Science, Vol 106, Iss 6, Pp 3761-3778 (2023)
ABSTRACT: Treatment of clinical mastitis (CM) and use of antimicrobials for dry cow therapy are responsible for the majority of animal-defined daily doses of antimicrobial use (AMU) on dairy farms. However, advancements made in the last decade have e
Externí odkaz:
https://doaj.org/article/373150b14cd445b29e2ca53cb967c546
Autor:
Victoria K. Woodcock, Ji‐Li Chen, Karin Purshouse, Chrissie Butcher, Linda Collins, Caroline Haddon, Gillian Verrall, Leena Elhussein, Corran Roberts, Andrea Tarlton, Margarida Rei, Giorgio Napolitani, Mariolina Salio, Mark R. Middleton, Vincenzo Cerundolo, Jeremy Crew, Andrew S. Protheroe
Publikováno v:
BJUI Compass, Vol 4, Iss 3, Pp 322-330 (2023)
Abstract Objectives This study aimed to investigate the anti‐PD‐1 inhibitor pembrolizumab as a potential agent for use in non‐muscle‐invasive bladder cancer (NMIBC) by conducting a Phase 1 safety run‐in study to assess the safety and tolera
Externí odkaz:
https://doaj.org/article/d7395c1210aa4beeac995f4f6e98382c
Autor:
David Thompson, Mark R Middleton, David J Pinato, Ian Walters, Robert Krämer, Uzi Gileadi, Nicholas Coupe, Justin Fairchild, Russell Poe, Carri Browne, Steven Innaimo, Carmela De Santo
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/aa74c1768bf44350af5b3cf61063e350
Autor:
Dirk Schadendorf, Gino K In, Mark R Middleton, Mohammed Milhem, Adel Samson, Bartosz Chmielowski, Michael K Wong, Robert S Coffin, Trisha M Wise-Draper, Eva Muñoz-Couselo, Joseph J Sacco, Georgia M Beasley, Judith Michels, Praveen K Bommareddy, Katy K Tsai, Jeannie W Hou, Alina Monteagudo, Tawnya Lynn Bowles, Ari M VanderWalde, Jason Alan Chesney, Fade Mahmoud, Walter Hong, Aaron Clack
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/4ff8ea73c0584af5a6764e1f92cc3eda
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 37, Iss 2, Pp 757-765 (2023)
Abstract Background Lameness is an economically important and common disease of cattle, and foot disease is the most common cause of lameness in cattle. Limited data is available regarding lameness in cow‐calf operations. Objectives Describe the ba
Externí odkaz:
https://doaj.org/article/d7d1cb32eba94aa6805fae5d354dee15