Zobrazeno 1 - 10
of 162
pro vyhledávání: '"A. R. Khomutov"'
Autor:
Alexander Yu Rudenko, Sofia S. Mariasina, Anastasiia K. Bolikhova, Maxim V. Nikulin, Ratislav M. Ozhiganov, Vasiliy G. Vasil’ev, Yuri A. Ikhalaynen, Anastasia L. Khandazhinskaya, Maxim A. Khomutov, Peter V. Sergiev, Alex R. Khomutov, Vladimir I. Polshakov
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
S-Adenosyl-l-methionine (SAM)-mediated methylation of biomolecules controls their function and regulates numerous vital intracellular processes. Analogs of SAM with a reporter group in place of the S-methyl group are widely used to study these proces
Externí odkaz:
https://doaj.org/article/77e58f40aa35434d87abbb35bd6ea9be
Autor:
Natalia F. Zakirova, Olga A. Khomich, Olga A. Smirnova, Jennifer Molle, Sarah Duponchel, Dmitry V. Yanvarev, Vladimir T. Valuev-Elliston, Lea Monnier, Boyan Grigorov, Olga N. Ivanova, Inna L. Karpenko, Mikhail V. Golikov, Cedric Bovet, Barbara Rindlisbacher, Alex R. Khomutov, Sergey N. Kochetkov, Birke Bartosch, Alexander V. Ivanov
Publikováno v:
Cells, Vol 13, Iss 12, p 1036 (2024)
Hepatitis C virus (HCV) is an oncogenic virus that causes chronic liver disease in more than 80% of patients. During the last decade, efficient direct-acting antivirals were introduced into clinical practice. However, clearance of the virus does not
Externí odkaz:
https://doaj.org/article/4a062fcad91f4c409b2a06d43ebfde9f
Autor:
Lucy O. Ojomoko, Elena V. Kryukova, Natalya S. Egorova, Arthur I. Salikhov, Lyubov A. Epifanova, Daria A. Denisova, Alex R. Khomutov, Dmitry A. Sukhov, Alexander A. Vassilevski, Maxim A. Khomutov, Victor I. Tsetlin, Irina V. Shelukhina
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Oligoarginine peptides, known mostly for their cell-penetrating properties, are also inhibitors of the nicotinic acetylcholine receptors (nAChRs). Since octa-arginine (R8) inhibits α9α10 nAChR and suppresses neuropathic pain, we checked if other po
Externí odkaz:
https://doaj.org/article/ab66a8f41b6945c19f9cb45777684225
Autor:
Tracy Murray Stewart, Jackson R Foley, Cassandra E Holbert, Maxim Khomutov, Noushin Rastkari, Xianzun Tao, Alex R Khomutov, R Grace Zhai, Robert A Casero Jr
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp n/a-n/a (2023)
Abstract Snyder–Robinson syndrome (SRS) results from mutations in spermine synthase (SMS), which converts the polyamine spermidine into spermine. Affecting primarily males, common manifestations of SRS include intellectual disability, osteoporosis,
Externí odkaz:
https://doaj.org/article/5cc8bb3c21394af3a39b11fa46178f84
Autor:
Maxim A. Khomutov, Fabio Giovannercole, Laura Onillon, Marija V. Demiankova, Byazilya F. Vasilieva, Arthur I. Salikhov, Sergey N. Kochetkov, Olga V. Efremenkova, Alex R. Khomutov, Daniela De Biase
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1451 (2023)
New antibiotics are unquestionably needed to fight the emergence and spread of multidrug-resistant bacteria. To date, antibiotics targeting bacterial central metabolism have been poorly investigated. By determining the minimal inhibitory concentratio
Externí odkaz:
https://doaj.org/article/e3cc8080fa684d93b2ab16ca9cd35e41
Autor:
Maxim A. Khomutov, Arthur I. Salikhov, Vladimir A. Mitkevich, Vera L. Tunitskaya, Olga A. Smirnova, Sergey P. Korolev, Alexander O. Chizhov, Marina B. Gottikh, Sergey N. Kochetkov, Alex R. Khomutov
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 916 (2023)
The biogenic polyamines, spermidine (Spd) and spermine (Spm), are present at millimolar concentrations in all eukaryotic cells, where they participate in the regulation of vitally important cellular functions. Polyamine analogs and derivatives are a
Externí odkaz:
https://doaj.org/article/83c8159615dd4817a7b904a1fbad6215
Autor:
Marija V. Demiankova, Fabio Giovannercole, Maxim A. Khomutov, Arthur I. Salikhov, Laura Onillon, Vladimir T. Valuev-Elliston, Byazilya F. Vasilieva, Elena N. Khurs, Nina I. Gabrielyan, Sergey N. Kochetkov, Olga V. Efremenkova, Daniela De Biase, Alex R. Khomutov
Publikováno v:
Molecules, Vol 28, Iss 3, p 1234 (2023)
The fast spread of bacteria that are resistant to many classes of antibiotics (multidrug resistant) is a global threat to human and animal health with a worrisome scenario ahead. Novel therapeutical strategies are of crucial importance to combat this
Externí odkaz:
https://doaj.org/article/3af157cebfa648c0bbca98cd8895f093
Autor:
Mervi T. Hyvönen, Olga A. Smirnova, Vladimir A. Mitkevich, Vera L. Tunitskaya, Maxim Khomutov, Dmitry S. Karpov, Sergey P. Korolev, Merja R. Häkkinen, Marko Pietilä, Marina B. Gottikh, Jouko Vepsäläinen, Leena Alhonen, Alexander A. Makarov, Sergey N. Kochetkov, Heather M. Wallace, Tuomo A. Keinänen, Alex R. Khomutov
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4614 (2022)
The polyamines, spermine (Spm) and spermidine (Spd), are important for cell growth and function. Their homeostasis is strictly controlled, and a key downregulator of the polyamine pool is the polyamine-inducible protein, antizyme 1 (OAZ1). OAZ1 inhib
Externí odkaz:
https://doaj.org/article/0c564f8e408144a997efe0c60a190534
Autor:
M. A. Khomutov, A. R. Khomutov
Publikováno v:
Russian Journal of Bioorganic Chemistry. 48:1202-1208
Autor:
Alexander V. Ivanov, Alex R. Khomutov
Publikováno v:
Biomolecules, Vol 12, Iss 1, p 14 (2021)
The specific regulation of cell metabolism is one of cornerstones of biochemistry [...]
Externí odkaz:
https://doaj.org/article/95ff5bc32a5b48619c98227c4acbacf7