Zobrazeno 1 - 10
of 811
pro vyhledávání: '"A. R. Hubbard"'
Autor:
Nathanael A. Caveney, Robert A. Saxton, Deepa Waghray, Caleb R. Glassman, Naotaka Tsutsumi, Stevan R. Hubbard, K. Christopher Garcia
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112201- (2023)
Summary: Janus kinases (JAKs) mediate signal transduction downstream of cytokine receptors. Cytokine-dependent dimerization is conveyed across the cell membrane to drive JAK dimerization, trans-phosphorylation, and activation. Activated JAKs in turn
Externí odkaz:
https://doaj.org/article/8f1e23ec408e4692ae142b0442ba46ad
Autor:
Anniina T. Virtanen, Teemu Haikarainen, Parthasarathy Sampathkumar, Maaria Palmroth, Sanna Liukkonen, Jianping Liu, Natalia Nekhotiaeva, Stevan R. Hubbard, Olli Silvennoinen
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 75 (2023)
Hyperactive mutation V617F in the JAK2 regulatory pseudokinase domain (JH2) is prevalent in patients with myeloproliferative neoplasms. Here, we identified novel small molecules that target JH2 of JAK2 V617F and characterized binding via biochemical
Externí odkaz:
https://doaj.org/article/6cfdba99ff324992a07f46b8c564e944
Autor:
Benjamin R. Hubbard, Joshua M. Pearce
Publikováno v:
HardwareX, Vol 8, Iss , Pp e00129- (2020)
To assist firefighters and other first responders to use their existing equipment for respiration during the COVID-19 pandemic without using single-use, low-supply, masks, this study outlines an open source kit to convert a 3M-manufactured Scott Safe
Externí odkaz:
https://doaj.org/article/b027022b451c4978a1a201886e5f00e3
Autor:
Lance R. Hubbard, Caleb J. Allen, Amy C. Sims, Kristin M. Engbrecht, Matthew J. O’Hara, Jared C. Johnson, Samuel S. Morrison
Publikováno v:
MRS Communications. 12:1160-1167
The near real-time detection of airborne particles-of-interest is needed for avoiding current/future threats. The incorporation of imprinted particles into a micelle-based electrochemical cell produced a signal when brought into contact with particle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aff3362e72dcbd6004d8967522f1142
https://doi.org/10.1557/s43579-022-00242-0
https://doi.org/10.1557/s43579-022-00242-0
Publikováno v:
Journal of Manufacturing and Materials Processing, Vol 5, Iss 2, p 52 (2021)
Vacuum drying can dehydrate materials further than dry heat methods, while protecting sensitive materials from thermal degradation. Many industries have shifted to vacuum drying as cost- or time-saving measures. Small-scale vacuum drying, however, ha
Externí odkaz:
https://doaj.org/article/3e3a63af380c46238b0efbd80099ab8a
Autor:
Savannah Gysling, H. Morgan, O. Ifesemen, D. West, J. Conibear, N. Navani, E. O’Dowd, D. Baldwin, D. Humes, R. Hubbard
Publikováno v:
Chest.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f132fba739144affe97b7f81554699e4
https://doi.org/10.1016/j.chest.2023.01.008
https://doi.org/10.1016/j.chest.2023.01.008
Autor:
Benjamin R. Hubbard, Joshua M. Pearce
Publikováno v:
Instruments, Vol 4, Iss 3, p 18 (2020)
This study provides designs for a low-cost, easily replicable open-source lab-grade digital scale that can be used as a precision balance. The design is such that it can be manufactured for use in most labs throughout the world with open-source RepRa
Externí odkaz:
https://doaj.org/article/5ec035ae4a3b4d219fc270aa0378bef1
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205540 (2018)
[This corrects the article DOI: 10.1371/journal.pone.0199942.].
Externí odkaz:
https://doaj.org/article/43404d5e9e884d0e8bf75781a545459d
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199942 (2018)
KCa3.1 (also known as SK4 or IK1) is a mammalian intermediate-conductance potassium channel that plays a critical role in the activation of T cells, B cells, and mast cells, effluxing potassium ions to maintain a negative membrane potential for influ
Externí odkaz:
https://doaj.org/article/08c2e39af35a4064a99714b33c6defc2
Autor:
Stevan R. Hubbard
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2018)
JAK2 is a member of the Janus kinase (JAKs) family of non-receptor protein tyrosine kinases, which includes JAK1–3 and TYK2. JAKs serve as the cytoplasmic signaling components of cytokine receptors and are activated through cytokine-mediated trans-
Externí odkaz:
https://doaj.org/article/e9aa7f4b76d34bafbc763da2d973eb99