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pro vyhledávání: '"A. R. Fritzberg"'
Publikováno v:
CHEMICAL and STRUCTURAL APPROACHES to RATIONAL DRUG DESIGN ISBN: 9781003068808
CHEMICAL and STRUCTURAL APPROACHES to RATIONAL DRUG DESIGN
CHEMICAL and STRUCTURAL APPROACHES to RATIONAL DRUG DESIGN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdfda88fc6181e592cb795827d4751ad
https://doi.org/10.1201/9781003068808-6
https://doi.org/10.1201/9781003068808-6
Autor:
Thomas A. Waldmann, Robert W. Mallett, Lou J. Theodore, Zhengsheng Yao, William C. Eckelman, Jorge A. Carrasquillo, Donald B. Axworthy, Chang H. Paik, Alan R. Fritzberg, Kayhan Garmestani, Meili Zhang, Paul S. Plascjak, Martin W. Brechbiel, Ira Pastan
Publikováno v:
Clinical Cancer Research. 10:3137-3146
Purpose: The use of an α emitter for radioimmunotherapy has potential advantages compared with β emitters. When administered systemically optimal targeting of intact antibodies requires >24 h, therefore limiting the use of short-lived α emitters.
Autor:
John M. Reno, Lori J. Hobson, Donald B. Axworthy, Paul L. Beaumier, Tripuraneni N. Rao, Alan R. Fritzberg, Ananthachari Srinivasan, James Sanderson, Jeffrey N. Fitzner, Sudhakar Kasina
Publikováno v:
Bioconjugate Chemistry. 9:108-117
A simplified kiet has been developed for 99mTc protein radiolabeling using an N3S triamide mercaptide bifunctional chelating agent and the preformed chelate approach. The process combined N3S chelating agent, gluconate intermediate transfer agent, st
Autor:
Alan R. Fritzberg
Publikováno v:
Journal of Molecular Recognition. 9:309-315
Publikováno v:
Journal of Controlled Release. 28:167-173
Antibodies with their ability to selectivity bind antigens have been of great interest in targeting radiation, drugs and toxins to tumors. Limited success in delivery of radioactivity has been enjoyed with conventional attachment to antibodies. This
Publikováno v:
Biochemical and Biophysical Research Communications. 194:876-884
Two peptide analogs of the 37-62 sequence region of the HIV TAT protein bind tightly to the surface of A431 breast carcinoma cells. After conjugation to either of two poorly internalized anti-tumor antibody Fab fragments, the analogs enhanced the in
Autor:
A. C. Morgan, D. C. Anderson, M. Barry, D. Woodle, J. Schroeder, Alan R. Fritzberg, R. Manger
Publikováno v:
Bioconjugate Chemistry. 4:10-18
The Fab fragments of two antitumor monoclonal antibodies, NR-ML-05 and NR-LU-10, have been covalently derivatized with synthetic peptides designed to provide secondary sites of attachment to enhance their retention on tumor cells. Analogs of the pept
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 44:S726-S728
The alpha emitter, Bismuth-213, (213Bi) T1/2 = 45 min, obtained from an 225Ac generator, was chelated to DOTA-biotin in high radiochemical yield and specific activity. The radiolabeled product showed good radiochemical stability and was used in precl
Autor:
Linda M. Gustavson, Ananthachari Srinivasan, Alan R. Fritzberg, Tripuraneni N. Rao, Sudhakar Kasina
Publikováno v:
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology. 19:889-895
The exchange reactions of S-protected dithiol monoaminemonoamide (MAMA) ligands with Tc(V)-gluconate were investigated. Protection of the mercaptide sulfur atoms with acid, base and metal labile groups permitted complex formation of the MAMA ligands