Zobrazeno 1 - 10
of 470
pro vyhledávání: '"A. R. Efimov"'
Autor:
A. R. Efimov
Publikováno v:
Интеллект. Инновации. Инвестиции, Vol 2, Pp 74-80 (2020)
This article attempts to comprehensively criticize the «Turing test» and develop quality criteria for new tests for assessing artificial intelligence. It is shown that the prerequisites for reducing personality and human consciousness, which A. Tu
Externí odkaz:
https://doaj.org/article/4762fb1fe4c4449e98abb6485b9487d7
Publikováno v:
Advanced Intelligent Systems, Vol 4, Iss 8, Pp n/a-n/a (2022)
Artificial intelligence algorithms are being adopted to analyze medical data, promising faster interpretation to support doctors’ diagnostics. The next frontier is to bring these powerful algorithms to implantable medical devices. Herein, a closed
Externí odkaz:
https://doaj.org/article/d7f3b00684f04238a5a0fc097ae9e258
Autor:
Stefanie Fenske, Konstantin Hennis, René D. Rötzer, Verena F. Brox, Elvir Becirovic, Andreas Scharr, Christian Gruner, Tilman Ziegler, Verena Mehlfeld, Jaclyn Brennan, Igor R. Efimov, Audrys G. Pauža, Markus Moser, Carsten T. Wotjak, Christian Kupatt, Rasmus Gönner, Rai Zhang, Henggui Zhang, Xiangang Zong, Martin Biel, Christian Wahl-Schott
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-22 (2020)
The involvement of cAMP-dependent regulation of HCN4 in the chronotropic heart rate response is a matter of debate. Here the authors use a knockin mouse model expressing cAMP-insensitive HCN4 channels to discover an inhibitory nonfiring cell pool in
Externí odkaz:
https://doaj.org/article/6c6af2794e4b4707a82af208feb04493
Autor:
Ching Zhu, Pradeep S. Rajendran, Peter Hanna, Igor R. Efimov, Guy Salama, Charless C. Fowlkes, Kalyanam Shivkumar
Publikováno v:
JCI Insight, Vol 7, Iss 3 (2022)
Remodeling of injured sympathetic nerves on the heart after myocardial infarction (MI) contributes to adverse outcomes such as sudden arrhythmic death, yet the underlying structural mechanisms are poorly understood. We sought to examine microstructur
Externí odkaz:
https://doaj.org/article/d303c0711ddb45038983a5f827d6cc21
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0259174 (2022)
Fluorescent imaging with voltage- or calcium-sensitive dyes, known as optical mapping, is one of the indispensable modern techniques to study cardiac or neural electrophysiology, unsurpassed by temporal and spatial resolution. High-speed CMOS cameras
Externí odkaz:
https://doaj.org/article/718da3868e8844ed83a9e4d3893a5fa4
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Cardiac tissue engineering requires materials that can faithfully recapitulate and support the native in vivo microenvironment while providing a seamless bioelectronic interface. Current limitations of cell scaffolds include the lack of electrical co
Externí odkaz:
https://doaj.org/article/bc09eb70ccba47efb6d8ffa2fec2ef15
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Optogenetic technology provides researchers with spatiotemporally precise tools for stimulation, sensing, and analysis of function in cells, tissues, and organs. These tools can offer low-energy and localized approaches due to the use of the transgen
Externí odkaz:
https://doaj.org/article/f2011cf816dd427e9dc6c9bb918b7375
Autor:
Arie O. Verkerk, Illés J. Doszpod, Isabella Mengarelli, Tibor Magyar, Alexandra Polyák, Bence Pászti, Igor R. Efimov, Ronald Wilders, István Koncz
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2987 (2022)
Vagal nerve stimulation (VNS) holds a strong basis as a potentially effective treatment modality for chronic heart failure, which explains why a multicenter VNS study in heart failure with reduced ejection fraction is ongoing. However, more detailed
Externí odkaz:
https://doaj.org/article/9d5e58f3a0cb46638f8f2e10772df109
Publikováno v:
Physiological Reports, Vol 9, Iss 15, Pp n/a-n/a (2021)
Abstract Introduction Doxorubicin (DOX), an anticancer drug used in chemotherapy, causes significant cardiotoxicity. This study aimed to investigate the effects of DOX on mouse cardiac electrophysiology, in conscious versus anesthetized state. Method
Externí odkaz:
https://doaj.org/article/a8aaff9e3db2441ea41cfc468f949b9f
Autor:
Philipp Gutruf, Rose T. Yin, K. Benjamin Lee, Jokubas Ausra, Jaclyn A. Brennan, Yun Qiao, Zhaoqian Xie, Roberto Peralta, Olivia Talarico, Alejandro Murillo, Sheena W. Chen, John P. Leshock, Chad R. Haney, Emily A. Waters, Changxing Zhang, Haiwen Luan, Yonggang Huang, Gregory Trachiotis, Igor R. Efimov, John A. Rogers
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Pacing tools that support small animals and can serve as models for pathogenesis of cardiovascular diseases are currently not available. Here, the authors report a miniaturized wireless battery-free implantable multimodal and multisite pacemaker that
Externí odkaz:
https://doaj.org/article/6dbd42b35661487d89a936efbf8c2f39