Výsledky vyhledávání - "A. R. Cazers"

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Kinetic evaluation of lipophilic inhibitors of lipid peroxidation in DLPC liposomes

Autor: Alex R. Cazers, Barry S. Lutzke, John M. McCall, Kelly L. Horan, Dennis E. Epps

Publikováno v: Free Radical Biology and Medicine. 17:587-596

The authors have developed a kinetic method that allows one to obtain relative reactivity constants for lipophilic antioxidants in free radical systems. Two experimental model systems were developed: (a) a methanolic solution using AMVN as the free r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36966ed4b7159892d2794ee1af90774
https://doi.org/10.1016/0891-5849(94)90098-1

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The use of salicylate hydroxylation to detect hydroxyl radical generation in ischemic and traumatic brain injury

Autor: John S. Althaus, Philip F. VonVoigtlander, Paula K. Andrus, Carl M. Williams, Edward D. Hall, Alexander R. Cazers

Publikováno v: Molecular and Chemical Neuropathology. 20:147-162

Oxygen free radicals have been implicated as a causal factor in posttraumatic neuronal cell loss following cerebral ischemia and head injury. The conversion of salicylate to dihydroxybenzoic acid (DHBA) in vivo was employed to study the formation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4bb3354f5bee775357349d13902f49d
https://doi.org/10.1007/bf02815368

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Two metabolites of anticonvulsant U-54494A: their anticonvulsant activity and interaction with sodium channel

Autor: Alexander R. Cazers, Richard A. Lewis, Yu Zhu, Wha-Bin Im, John R. Palmer, John S. Althaus, Philip F. Von Voigtlander, James W. Nielsen

Publikováno v: Brain Research. 606:50-55

U-54494A,3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzamide, has been shown to be a potent and long-acting anticonvulsant without analgesic or sedative effects on intact animals. The persistence of anticonvulsant activity after a decline

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dea8baccd318ae8528fe9c9d3151e03
https://doi.org/10.1016/0006-8993(93)91568-d

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Environmental fate of ceftiofur sodium, a cephalosporin antibiotic. Role of animal excreta in its decomposition

Autor: P. J. Hamlow, Jean M. Nappier, K. T. Koshy, Terry J. Gilbertson, G. L. Stahl, A. R. Cazers, Rex E. Hornish, Marc F. Kubicek, John L. Nappier, Gregory A. Hoffman, Prem S. Jaglan

Publikováno v: Journal of Agricultural and Food Chemistry. 38:890-894

The degradation of ceftiofur sodium, a wide-spectrum cephalosporin antibiotic, was studied in the urine and feces of cattle, in three soils, and in buffers of pH 5, 7, and 9. Photodegradation was also studied. Fortification of cattle feces with [14C]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24b5bd969d2afeae73429cad06fc46ed
https://doi.org/10.1021/jf00093a064

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Controlled hydrolysis of ceftiofur sodium, a broad-spectrum cephalosporin; isolation and identification of hydrolysis products

Autor: K. Thomas Koshy, Alexander R. Cazers

Publikováno v: Journal of pharmaceutical sciences. 86(3)

Ceftiofur sodium is the salt of (6R,7R)-7-{[(2-amino-4-thiazolyl)-Z-(methoxyimino)acetyl]amino}-3-{[(2-+ ++furanylcarbonyl)thio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2- ene-2-carboxylic acid. This compound is very susceptible to acid, alkaline-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2c3a132d35819d6cb2b8f7c6efe962
https://pubmed.ncbi.nlm.nih.gov/9050811

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HPLC-chemiluminescence and thermospray LC/MS study of hydroperoxides generated from phosphatidylcholine

Autor: Edward D. Hall, Jue-Rong Zhang, Alexander R. Cazers, Barry S. Lutzke

Publikováno v: Free radical biologymedicine. 18(1)

Lipid hydroperoxides generated from phosphatidylcholine (PC) by two commonly employed phosphatidylcholine hydroperoxide (PCOOH) generation methods were examined by HPLC-chemiluminescence (CL) and thermospray LC/MS assay. This HPLC-CL assay is specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ea6bed20643fba311c5ea311e34589
https://pubmed.ncbi.nlm.nih.gov/8582672

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