Zobrazeno 1 - 10
of 401
pro vyhledávání: '"A. R. Buckpitt"'
Autor:
Bruce D. Hammock, Jun Yang, Cindy B. McReynolds, Irene Cortés-Puch, Karen Wagner, Glenn Croston, Sung Hee Hwang, Kin Sing Stephen Lee, Alan R. Buckpitt, William K. Schmidt
Publikováno v:
J Med Chem
[Image: see text] This report describes the development of an orally active analgesic that resolves inflammation and neuropathic pain without the addictive potential of opioids. EC5026 acts on the cytochrome P450 branch of the arachidonate cascade to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632e91f5b8a7801ac3a668e935a4855b
https://doi.org/10.1021/acs.jmedchem.0c01886
https://doi.org/10.1021/acs.jmedchem.0c01886
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0121937 (2015)
Naphthalene is an environmental toxicant to which humans are exposed. Naphthalene causes dose-dependent cytotoxicity to murine airway epithelial cells but a link between exposure and human pulmonary disease has not been established. Naphthalene toxic
Externí odkaz:
https://doaj.org/article/67846a451ed946e19a36cdbe1f239ce8
Autor:
D. M. Hyde, L. A. Miller, E. S. Schelegle, M. V. Fanucchi, L. S. Van Winkle, N. K. Tyler, M. V. Avdalovic, M. J. Evans, R. Kajekar, A. R. Buckpitt, K. E. Pinkerton, J. P. Joad, L. J. Gershwin, R. Wu, C. G. Plopper
Publikováno v:
European Respiratory Review, Vol 15, Iss 101, Pp 122-135 (2006)
Asthma is a worldwide health problem that affects 300 million people, as estimated by the World Health Organization. A key question in light of this statistic is: "what is the most appropriate laboratory animal model for human asthma?" The present au
Externí odkaz:
https://doaj.org/article/2f3c593e59aa4693bff89c6dcf3e10b1
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42053 (2012)
Naphthalene is a volatile polycyclic aromatic hydrocarbon generated during combustion and is a ubiquitous chemical in the environment. Short term exposures of rodents to air concentrations less than the current OSHA standard yielded necrotic lesions
Externí odkaz:
https://doaj.org/article/6359ec9c9d5d4f6f9fe69df6cf3f1eb0
Autor:
John B. Morris, Laura S. Van Winkle, Alan R. Buckpitt, Joseph A. Cichocki, Ryan Mendoza, Gregory J. Smith
Publikováno v:
Toxicological Sciences. 139:234-244
Naphthalene is a nasal carcinogen, inducing respiratory adenomas in male and olfactory neuroblastomas in female rats, respectively. The reasons for the site and sex-specific tumorigenic response are unknown. Naphthalene is bioactivated to electrophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ed0ac1feed9abf26265f235e33d66c
https://doi.org/10.1093/toxsci/kfu031
https://doi.org/10.1093/toxsci/kfu031
Naphthalene (NA) is a ubiquitous pollutant to which humans are widely exposed. 1,2-Dihydro-1,2-dihydroxynaphthalene (NA-dihydrodiol) is a major metabolite of NA generated by microsomal epoxide hydrolase (mEH). To investigate the role of the NA-dihydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2744098f59db7a826001e13029ac832e
https://escholarship.org/uc/item/7061n1kg
https://escholarship.org/uc/item/7061n1kg
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 43:316-325
Naphthalene (NA) is a semivolatile aromatic hydrocarbon to which humans are exposed from a variety of sources. NA results in acute cytotoxicity to respiratory epithelium in rodents. Cytochrome P450-dependent metabolic activation to form reactive inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ea8f0fa15f26862537da412030446e
https://doi.org/10.1165/rcmb.2009-0135oc
https://doi.org/10.1165/rcmb.2009-0135oc
Publikováno v:
Environmental Health Perspectives
Background Naphthalene is a volatile hydrocarbon that causes dose-, species-, and cell type–dependent cytotoxicity after acute exposure and hyperplasia/neoplasia after lifetime exposures in rodents. Toxicity depends on metabolic activation, and rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df527d3a09b925c881b2d5377cdbdad0
https://doi.org/10.1289/ehp.0901333
https://doi.org/10.1289/ehp.0901333
Autor:
John B. Morris, Alan R. Buckpitt
Publikováno v:
Toxicological Sciences. 111:383-391
Naphthalene is a nasal toxicant and carcinogen in the rat. Upper respiratory tract (URT) uptake of naphthalene was measured in the male and female F344 rat at exposure concentrations of 1, 4, 10, or 30 ppm at inspiratory flow rates of 150 or 300 ml/m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023223cdec8bc57368a93121f61b8a18
https://doi.org/10.1093/toxsci/kfp138
https://doi.org/10.1093/toxsci/kfp138
Publikováno v:
Archives of Biochemistry and Biophysics. 485:49-55
Substantial gaps exist in our knowledge of the metabolic clearance of therapeutic agents in horses. Accordingly, a cytochrome P450 monooxygenase in the 2C family was cloned from an equine liver, sequenced and expressed in a baculovirus expression sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fd603648352f1deae04d4ae157a7f3
https://doi.org/10.1016/j.abb.2009.02.009
https://doi.org/10.1016/j.abb.2009.02.009