Zobrazeno 1 - 10
of 402
pro vyhledávání: '"A. R. Brasier"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/8c7749c29ef344cb95a81c910dd4f845
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe human orthopneumovirus, Respiratory Syncytial Virus (RSV), is the causative agent of severe lower respiratory tract infections (LRTI) and exacerbations of chronic lung diseases. In immune competent hosts, RSV productively infects high
Externí odkaz:
https://doaj.org/article/2ac32dbd477c4ebc93c9a44112e5308c
Publikováno v:
Journal of Clinical and Translational Science, Vol 8 (2024)
External advisory committees (EACs) are critical peer-review meetings that drive improvement at Clinical and Translational Science Award Program Hubs. Despite their ubiquity, evaluations of EAC optimization and effective implementation remain scarce.
Externí odkaz:
https://doaj.org/article/afee707492ef481c8b9f1f16ce2985ab
Autor:
Allan R. Brasier
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 340-342 (2023)
Externí odkaz:
https://doaj.org/article/68ff76d5e7f0401cab258ba5ee391b81
Autor:
Lang Pan, Spiros Vlahopoulos, Lloyd Tanner, Jesper Bergwik, Attila Bacsi, Zsolt Radak, Arne Egesten, Xueqing Ba, Allan R. Brasier, Istvan Boldogh
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Recent advances have uncovered the non-random distribution of 7, 8-dihydro-8-oxoguanine (8-oxoGua) induced by reactive oxygen species, which is believed to have epigenetic effects. Its cognate repair protein, 8-oxoguanine DNA glycosylase 1 (OGG1), re
Externí odkaz:
https://doaj.org/article/340dac68eeb842cba993be2b6019607c
Autor:
Yaoyao Xue, Lang Pan, Spiros Vlahopoulos, Ke Wang, Xu Zheng, Zsolt Radak, Attila Bacsi, Lloyd Tanner, Allan R. Brasier, Xueqing Ba, Istvan Boldogh
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Interferons (IFNs) are secreted cytokines with the ability to activate expression of IFN stimulated genes that increase resistance of cells to virus infections. Activated transcription factors in conjunction with chromatin remodelers induce epigeneti
Externí odkaz:
https://doaj.org/article/672e0898900943f687352329b70e5da3
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe unfolded protein response (UPR) has emerged as an important signaling pathway mediating anti-viral defenses to Respiratory Syncytial Virus (RSV) infection. Earlier we found that RSV replication predominantly activates the evolutionari
Externí odkaz:
https://doaj.org/article/a0a13e3f30644240974949af762dcb9e
Autor:
Morgan W. Mann, Yao Fu, Robert L. Gearhart, Xiaofang Xu, David S. Roberts, Yi Li, Jia Zhou, Ying Ge, Allan R. Brasier
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionBromodomain-containing Protein 4 (BRD4) is a transcriptional regulator which coordinates gene expression programs controlling cancer biology, inflammation, and fibrosis. In the context of airway viral infection, BRD4-specific inhibitors (
Externí odkaz:
https://doaj.org/article/2883b714e680481cbee4ff761684ca8c
Autor:
Xu Zheng, Ke Wang, Lang Pan, Wenjing Hao, Yaoyao Xue, Attila Bacsi, Spiros A. Vlahopoulos, Zsolt Radak, Tapas K. Hazra, Allan R. Brasier, Lloyd Tanner, Xueqing Ba, Istvan Boldogh
Publikováno v:
Journal of Innate Immunity, Pp 1-22 (2022)
The primary cause of morbidity and mortality from infection with respiratory syncytial virus (RSV) is the excessive innate immune response(s) (IIR) in which reactive oxygen species (ROS) play key role(s). However, the mechanisms for these processes a
Externí odkaz:
https://doaj.org/article/ba22675d361a4cf585f761a801225ab6
Publikováno v:
Journal of Clinical and Translational Science, Vol 7 (2023)
The Clinical and Translational Science Awards (CTSA) Program supports a national network of medical research institutions working to improve the translational process. High-performing translational teams (TTs) are critical for advancing evidence-base
Externí odkaz:
https://doaj.org/article/9a325f98e3bf497f946b3a6f13b7a35f