Zobrazeno 1 - 10
of 568
pro vyhledávání: '"A. R. Beattie"'
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT Fungal infections are a major contributor to morbidity and mortality among immunocompromised populations. Moreover, fungal disease caused by molds are difficult to treat and are associated with particularly high mortality. To address the nee
Externí odkaz:
https://doaj.org/article/70b21e539a2f496e8b7540798e3d2020
Autor:
Martin T. Kelty, Sarah R. Beattie
Publikováno v:
mSphere, Vol 8, Iss 6 (2023)
ABSTRACTFungal infections of the central nervous system are associated with high mortality and limited treatment options due to the poor permeability of the blood brain barrier to most antifungal drugs. The most common pathogenic mold is Aspergillus
Externí odkaz:
https://doaj.org/article/474ca213a0f741b0bd92fa779a37cfce
Autor:
Marion Vanneste, Anita Venzke, Soumitra Guin, Andrew J. Fuller, Andrew J. Jezewski, Sarah R. Beattie, Damian J. Krysan, Marvin J. Meyers, Michael D. Henry
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionAn attractive, yet unrealized, goal in cancer therapy is repurposing psychiatric drugs that can readily penetrate the blood-brain barrier for the treatment of primary brain tumors and brain metastases. Phenothiazines (PTZs) have demonstra
Externí odkaz:
https://doaj.org/article/4334b357eab940c8a068c9537ffc9a99
Publikováno v:
Frontiers in Astronomy and Space Sciences, Vol 9 (2022)
The interstellar medium (ISM) of star-forming galaxies is magnetized and turbulent. Cosmic rays (CRs) propagate through it, and those with energies from ∼ GeV − TeV are likely subject to the streaming instability, whereby the wave damping process
Externí odkaz:
https://doaj.org/article/b097df1b67594f2fb89c7f2f5452b5d0
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Cryptococcus neoformans is an important human fungal pathogen for which the external environment is its primary niche. Previous work has shown that two nonessential acetyl-CoA metabolism enzymes, ATP-citrate lyase (ACL1) and acetyl-CoA synth
Externí odkaz:
https://doaj.org/article/bd16bbc803804fdeb26e1007ccc8eab4
Publikováno v:
mSphere, Vol 7, Iss 3 (2022)
ABSTRACT There is an urgent need for new antifungals to treat cryptococcal meningoencephalitis, a leading cause of mortality in people living with HIV/AIDS. An important aspect of antifungal drug development is the validation of targets to determine
Externí odkaz:
https://doaj.org/article/90283ac21d334841b8e9d5b29829280e
Autor:
Joshua D. Kerkaert, François Le Mauff, Benjamin R. Wucher, Sarah R. Beattie, Elisa M. Vesely, Donald C. Sheppard, Carey D. Nadell, Robert A. Cramer
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Alanine metabolism has been suggested as an adaptation strategy to oxygen limitation in organisms ranging from plants to mammals. Within the pulmonary infection microenvironment, Aspergillus fumigatus forms biofilms with steep oxygen gradien
Externí odkaz:
https://doaj.org/article/3bd073db2b1b4278a1251f0c1e9a963e
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT Cryptococcus neoformans is an environmental yeast and an opportunistic human pathogen. The ability to cause disease depends on the ability to adapt to the human host. Previous studies implicated infectivity-related kinase 3 (IRK3, CNAG_03048
Externí odkaz:
https://doaj.org/article/186a109b7d36473eb4575083a549f2f3
Autor:
Anita C. Risch, Deborah S. Page-Dumroese, Anna K. Schweiger, James R. Beattie, Mike P. Curran, Leena Finér, Mike D. Hyslop, Yong Liu, Martin Schütz, Tom A. Terry, Weiwei Wang, Martin F. Jurgensen
Publikováno v:
Frontiers in Forests and Global Change, Vol 5 (2022)
Forest ecosystems sequester approximately half of the world’s organic carbon (C), most of it in the soil. The amount of soil C stored depends on the input and decomposition rate of soil organic matter (OM), which is controlled by the abundance and
Externí odkaz:
https://doaj.org/article/2e5e83e8078f44a1b64f83fb5568ae55
Publikováno v:
Ecology and Evolution, Vol 10, Iss 2, Pp 1054-1068 (2020)
Abstract Metal box (e.g., Elliott, Sherman) traps and remote cameras are two of the most commonly employed methods presently used to survey terrestrial mammals. However, their relative efficacy at accurately detecting cryptic small mammals has not be
Externí odkaz:
https://doaj.org/article/afa76e82f65c4c819e6936badaf665fc