Zobrazeno 1 - 10
of 45
pro vyhledávání: '"A. Pilar Forns"'
Autor:
Laura Vidal, Miriam Andrés, Marta Mir, Pilar Forns, Sara Sevilla, Bernat Vidal, Estrella Lozoya, Cristina Esteve, Mónica Bravo, Manel Ferrer, Paul R. Eastwood, Richard S. Roberts, Jordi Castro, Elena Gómez, Marta Calbet, Pere Vilaseca, Jacob González, Imma Moreno, Silvia Petit, J. A. Alonso, Maria Antonia Buil
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5127-5133
The correct positioning and orientation of an hydrogen bond acceptor (HBA) in the tail portion of the biaryl series of CRTh2 antagonists is a requirement for long receptor residence time. The HBA in combination with a small steric substituent in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b468e1247865bc00ad5b1e097179b4b4
https://doi.org/10.1016/j.bmcl.2014.08.028
https://doi.org/10.1016/j.bmcl.2014.08.028
Autor:
Richard S. Roberts, Maria Antonia Buil, Peter Eichhorn, Paul R. Eastwood, Imma Moreno, Silvia Petit, Pilar Forns, Jordi Castro, Oscar Casado, Manel Ferrer, Miriam Andrés, Marta Calbet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5111-5117
Pyrrolopiperidinone acetic acids (PPAs) were identified as highly potent CRTh2 receptor antagonists. In addition, many of these compounds displayed slow-dissociation kinetics from the receptor. Structure–kinetic relationship (SKR) studies allowed o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43cdea5257f6e6d7e0e15c8e6c4dd8b5
https://doi.org/10.1016/j.bmcl.2014.08.026
https://doi.org/10.1016/j.bmcl.2014.08.026
Autor:
Montserrat Miralpeix, Manel López, Marcos Castillo, Montse Erra, Adelina Orellana, Bernat Vidal, Marta Mir, Pilar Forns, Isabel Ramis, M. I. Maldonado, Cristina Carreño
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5419-5423
A novel class of potent Syk inhibitors has been developed from rational design. Highly potent aminopyridine derivatives bearing a 4-trifluoromethyl-2-pyridyl motif and represented by compound 13b IC50: 0.6 nM were identified. Substitution by a 2-pyra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e90581305020a2c193ef25ff0d38fc7
https://doi.org/10.1016/j.bmcl.2012.07.045
https://doi.org/10.1016/j.bmcl.2012.07.045
Autor:
Bernat Vidal, Lorena Taboada, MA López, Cristina Esteve, Pilar Forns, Montserrat Miralpeix, J. A. Alonso, Isabel Ramis, Adelina Orellana, Cristina Carreño, M. I. Maldonado
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2784-2788
A series of aminopyrazines as inhibitors of Syk kinase activity and showing inhibition of LAD2 cells degranulation is described. Optimization of the carboxamide motif with aminomethylpiperidines provided high potency inhibiting Syk but low cellular a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f661b9ff5ee420b9089e9c87f044a5d9
https://doi.org/10.1016/j.bmcl.2012.02.087
https://doi.org/10.1016/j.bmcl.2012.02.087
Autor:
Pere Vilaseca, Marcos Castillo, Bernat Vidal, Cristina Esteve, Richard S. Roberts, Sara Sevilla, Manel Ferrer, Maria Antonia Buil, Jordi Castro, Sara López, Marta Calbet, Laura Vidal, Pilar Forns, Jacob González
Publikováno v:
European journal of medicinal chemistry. 113
Monocyclic and bicyclic ring systems were investigated as the "core" section of a series of diphenylsulphone-containing acetic acid CRTh2 receptor antagonists. A range of potencies were observed and single-digit nanomolar potencies were obtained in b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a6c6b9b155a1106830810a4455f0c4
https://pubmed.ncbi.nlm.nih.gov/26922232
https://pubmed.ncbi.nlm.nih.gov/26922232
Autor:
Joan-Carles Fernàndez, Natalia de la Figuera, Paul R. Eastwood, Sandra Fiol, Fernando Albericio, Pilar Forns
Publikováno v:
QSAR & Combinatorial Science. 27:1267-1273
The immobilization and reactions of indazol-3-carboxylic acid on the solid phase is described. These reactions are of importance since many biologically active compounds contain an indazole core. Here, indazole 3-carboxylic acid was efficiently ancho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53627a7e418c5e48f679a1ae9c3da1e0
https://doi.org/10.1002/qsar.200860005
https://doi.org/10.1002/qsar.200860005
Autor:
Pilar Forns, Dolors Fernández-Forner, Natalia de la Figuera, Fernando Albericio, Joan C. Fernandez, Sandra Fiol
Publikováno v:
Letters in Organic Chemistry. 5:374-378
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc15cbb44516e40a4348290508198585
https://doi.org/10.2174/157017808784872098
https://doi.org/10.2174/157017808784872098
Autor:
Fernando Albericio, Joan-Carles Fernàndez, Aina Colombo, Natalia de la Figuera, Pilar Forns, Dolors Fernández-Forner
Publikováno v:
Tetrahedron Letters. 49:1569-1572
Diastereoselectivity in the oxidation of different 4-thiazolidinones was discussed. Alkylation of these compounds with benzyl bromide was also studied. The stereoselectivity obtained was interpreted by the presence of the sulfoxide.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc7f8406b1c55fb206eeaedafdc5bceb
https://doi.org/10.1016/j.tetlet.2008.01.038
https://doi.org/10.1016/j.tetlet.2008.01.038
Autor:
Fernando Albericio, Joan-Carles Fernàndez, Natalia de la Figuera, Pilar Forns, Dolors Fernández-Forner, Aina Colombo
Publikováno v:
Organic Letters. 9:4319-4322
Synthesis and applications of two new nonacid degradable linkers as an alternative to the Wang linker for solid-phase synthesis are described. Resin from linker 2 looks superior to linker 1 in terms of yields for both anchoring of the first building
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8584b42b97a9eca46206ad3c29c99dac
https://doi.org/10.1021/ol701879s
https://doi.org/10.1021/ol701879s
Publikováno v:
Tetrahedron: Asymmetry. 17:3327-3331
The asymmetric oxidation of a sulfide in the solid phase using two distinct scaffolds as models is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f70f6cd84d97d870ff263913b9019b5a
https://doi.org/10.1016/j.tetasy.2006.12.014
https://doi.org/10.1016/j.tetasy.2006.12.014