Zobrazeno 1 - 10
of 698
pro vyhledávání: '"A. Pichlmair"'
This technical report presents the Drama Engine, a novel framework for agentic interaction with large language models designed for narrative purposes. The framework adapts multi-agent system principles to create dynamic, context-aware companions that
Externí odkaz:
http://arxiv.org/abs/2408.11574
Autor:
A.B.C. Schuren, I.G.J. Boer, E.M. Bouma, M.L. Van de Weijer, A.I. Costa, P. Hubel, A. Pichlmair, R.J. Lebbink, E.J.H.J. Wiertz
Publikováno v:
Molecules, Vol 26, Iss 2, p 287 (2021)
To prevent accumulation of misfolded proteins in the endoplasmic reticulum, chaperones perform quality control on newly translated proteins and redirect misfolded proteins to the cytosol for degradation by the ubiquitin-proteasome system. This pathwa
Externí odkaz:
https://doaj.org/article/f001c82e43164dd99815cb15af00e8af
Autor:
Yiqi Huang, Valter Bergant, Vincent Grass, Quirin Emslander, M. Sabri Hamad, Philipp Hubel, Julia Mergner, Antonio Piras, Karsten Krey, Alexander Henrici, Rupert Öllinger, Yonas M. Tesfamariam, Ilaria Dalla Rosa, Till Bunse, Gerd Sutter, Gregor Ebert, Florian I. Schmidt, Michael Way, Roland Rad, Andrew G. Bowie, Ulrike Protzer, Andreas Pichlmair
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Multiple omics analyzes of Vaccinia virus (VACV) infection have defined molecular characteristics of poxvirus biology. However, little is known about the monkeypox (mpox) virus (MPXV) in humans, which has a different disease manifestation de
Externí odkaz:
https://doaj.org/article/b2ed5b05f7224f76b575fd05ca07bceb
Autor:
Søren R. Paludan, Thomas Pradeu, Andreas Pichlmair, K. Brad Wray, Jacob Giehm Mikkelsen, David Olagnier, Trine H. Mogensen
Publikováno v:
Cell Reports, Vol 43, Iss 12, Pp 115070- (2024)
Summary: Early host defense eliminates many viruses before infections are established while clearing others so they remain subclinical or cause only mild disease. The field of immunology has been shaped by broad concepts, including the pattern recogn
Externí odkaz:
https://doaj.org/article/249ddee3b8534e9991c399928bee1cf4
Autor:
Freppel, Wesley 1, 10, Barragan Torres, Viviana Andrea 1, 11, Uyar, Olus 1, 11, Anton, Anaïs 1, 11, Nouhi, Zaynab 2, Broquière, Mathilde 1, Mazeaud, Clément 1, Sow, Aïssatou Aïcha 1, Léveillé, Alexanne 1, Gilbert, Claudia 1, Tremblay, Nicolas 1, Owen, Jonathan Eintrez 3, Bemis, Cheyanne L. 3, Laulhé, Xavier 1, Lamarre, Alain 1, Neufeldt, Christopher J. 3, Rodrigue-Gervais, Ian Gaël 1, Pichlmair, Andreas 4, 5, Girard, Denis 1, Scaturro, Pietro 4, 6, Hulea, Laura 2, 7, Chatel-Chaix, Laurent 1, 8, 9, 12, ∗
Publikováno v:
In iScience 17 January 2025 28(1)
Autor:
Paludan, Søren R. 1, 2, 3, ∗, Pradeu, Thomas 4, 5, 6, Pichlmair, Andreas 2, 7, 8, Wray, K. Brad 2, 9, 10, Mikkelsen, Jacob Giehm 1, 2, Olagnier, David 1, 2, Mogensen, Trine H. 1, 2, 11
Publikováno v:
In Cell Reports 24 December 2024 43(12)
Autor:
Christoph Gruber, Lea Krautner, Valter Bergant, Vincent Grass, Zhe Ma, Lara Rheinemann, Ariane Krus, Friederike Reinhardt, Lyupka Mazneykova, Marianne Rocha-Hasler, Dong-Jiunn Jeffery Truong, Gil Gregor Westmeyer, Andreas Pichlmair, Gregor Ebert, Florian Giesert, Wolfgang Wurst
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/c3b4e2ed843f489ba0d01bf423957cc6
Autor:
Huang, Yiqi 1, 6, Urban, Christian 1, 6, Hubel, Philipp 2, 6, Stukalov, Alexey 1, 5, Pichlmair, Andreas 1, 3, 4, 5, 7, ∗
Publikováno v:
In Cell Systems 16 October 2024 15(10):911-929
Autor:
Solène Denolly, Alexey Stukalov, Uladzimir Barayeu, Alina N. Rosinski, Paraskevi Kritsiligkou, Sebastian Joecks, Tobias P. Dick, Andreas Pichlmair, Ralf Bartenschlager
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Zika virus (ZIKV) has emerged as a global health issue, yet neither antiviral therapy nor a vaccine are available. ZIKV is an enveloped RNA virus, replicating in the cytoplasm in close association with ER membranes. Here, we isolate ER membr
Externí odkaz:
https://doaj.org/article/e994d1107b8b43ba817ee5beb730274a
Autor:
Valter Bergant, Daniel Schnepf, Niklas de Andrade Krätzig, Philipp Hubel, Christian Urban, Thomas Engleitner, Ronald Dijkman, Bernhard Ryffel, Katja Steiger, Percy A. Knolle, Georg Kochs, Roland Rad, Peter Staeheli, Andreas Pichlmair
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Changes of mRNA 3’UTRs by alternative polyadenylation (APA) have been associated to numerous pathologies, but the mechanisms and consequences often remain enigmatic. By combining transcriptomics, proteomics and recombinant viruses we show
Externí odkaz:
https://doaj.org/article/41b117276b3642cfa472a74a5a5f4522