Zobrazeno 1 - 10
of 882
pro vyhledávání: '"A. Peschiulli"'
Autor:
Rombouts, Frederik J.R., Hsiao, Chien-Chi, Bache, Solène, De Cleyn, Michel, Heckmann, Pauline, Leenaerts, Jos, Martinéz-Lamenca, Carolina, Van Brandt, Sven, Peschiulli, Aldo, Vos, Ann, Gijsen, Harrie J.M.
Publikováno v:
In European Journal of Medicinal Chemistry 15 January 2022 228
Autor:
Meyer, Claudio F., Hell, Sandrine M., Sap, Jeroen B.I., Misale, Antonio, Peschiulli, Aldo, Oehlrich, Daniel, Trabanco, Andrés A., Gouverneur, Véronique
Publikováno v:
In Tetrahedron 22 November 2019 75(47)
Akademický článek
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Publikováno v:
In International Journal of Thermal Sciences November 2017 121:75-88
Autor:
Ann Vos, Frederik Jan Rita Rombouts, Andrés A. Trabanco, Daniel Oehlrich, Harrie J.M. Gijsen, Diederik Moechars, Sven Franciscus Anna Van Brandt, Aldo Peschiulli, Gregor James Macdonald, Michel Surkyn, Gary Tresadern, Michiel Van Gool, Nigel E. Austin, Michel Anna Jozef De Cleyn
Publikováno v:
ACS Med Chem Lett
[Image: see text] We recently disclosed a set of heteroaryl-fused piperazine inhibitors of BACE1 that combined nanomolar potency with good intrinsic permeability and low Pgp-mediated efflux. Herein we describe further work on two prototypes of this f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a245817121859b9f393819774f0f13
https://doi.org/10.1021/acsmedchemlett.1c00445
https://doi.org/10.1021/acsmedchemlett.1c00445
Autor:
Frederik J. Rombouts, Lento William, Ingrid Velter, Ann Vos, Aldo Peschiulli, Reuillon Tristan, Maria Dominguez Blanco, Matthieu Jouffroy, Lisa McQueen, Helena Steyvers, Mariette Bekkers, Cristina Altrocchi, Beth Pietrak, Seong Joo Koo, Lawrence Szewczuk, David Walker, Kathryn Packman, Ruud Bueters, Petra Vinken, Amy Johnson, Ricardo Attar, Ulrike Philippar
Publikováno v:
Cancer Research. 82:2133-2133
Appropriate control of cell death is a fundamental biological process which is frequently dysregulated during tumor development and therapeutic resistance. Apoptosis is a form of regulated cell death initiated by either the extracellular environment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d26c71d6d913e202af7c340f376b66d7
https://doi.org/10.1158/1538-7445.am2022-2133
https://doi.org/10.1158/1538-7445.am2022-2133
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Ann Vos, Aldo Peschiulli, Frederik J. R. Rombouts, Sven Franciscus Anna Van Brandt, Pauline Heckmann, Michel Anna Jozef De Cleyn, Solène Bache, Carolina Martinez-Lamenca, Jos Leenaerts, Harrie J.M. Gijsen, Chien-Chi Hsiao
Publikováno v:
European journal of medicinal chemistry. 228
A common challenge for medicinal chemists is to reduce the pKa of strongly basic groups' conjugate acids into a range that preserves the desired effects, usually potency and/or solubility, but avoids undesired effects like high volume of distribution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e41dc8a2b5e76fa00d5c7ba322fab75
https://pubmed.ncbi.nlm.nih.gov/34920170
https://pubmed.ncbi.nlm.nih.gov/34920170
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 April 2020 30(8)
Autor:
Kirsten E. Christensen, David M. H. Ascough, Alberto Fontana, Giulia Roagna, Gabriele Pupo, Anna Chiara Vicini, Andrés A. Trabanco, Francesco Ibba, Antonio Misale, Aldo Peschiulli, Robert S. Paton, Daniel Oehlrich, Véronique Gouverneur
Publikováno v:
Journal of the American Chemical Society
Ammonium salts are used as phase-transfer catalysts for fluorination with alkali metal fluorides. We now demonstrate that these organic salts, specifically azetidinium triflates, are suitable substrates for enantioselective ring opening with CsF and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0fb8d2517522978684b8e34c8267f7
https://doi.org/10.1021/jacs.0c05131
https://doi.org/10.1021/jacs.0c05131
