Zobrazeno 1 - 10
of 73
pro vyhledávání: '"A. Paul Mould"'
Autor:
Tomasz M. Witkos, Wing Lee Chan, Merja Joensuu, Manuel Rhiel, Ed Pallister, Jane Thomas-Oates, A. Paul Mould, Alex A. Mironov, Christophe Biot, Yann Guerardel, Willy Morelle, Daniel Ungar, Felix T. Wieland, Eija Jokitalo, May Tassabehji, Uwe Kornak, Martin Lowe
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
COPI is recruited to the membrane by binding to Arf GTPases. Here the authors find that GORAB, a trans-Golgi protein, promotes COPI recruitment by forming membrane domains that also contain the COPI-interacting protein Scyl1, which is required for ef
Externí odkaz:
https://doaj.org/article/dc9f0e13809c4552a229477915667865
Autor:
Deepankar Gahloth, Graham Heaven, Thomas A. Jowitt, A. Paul Mould, Jordi Bella, Clair Baldock, Philip Woodman, Lydia Tabernero
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract HD-PTP is a tumour suppressor phosphatase that controls endocytosis, down-regulation of mitogenic receptors and cell migration. Central to its role is the specific recruitment of critical endosomal sorting complexes required for transport (E
Externí odkaz:
https://doaj.org/article/fb9b761d30ea4a3cbb093b0b72f678dd
Autor:
Richard B. Tunnicliffe, William K. Hu, Michele Y. Wu, Colin Levy, A. Paul Mould, Edward A. McKenzie, Rozanne M. Sandri-Goldin, Alexander P. Golovanov
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT Serine-arginine (SR) protein kinase 1 (SRPK1) catalyzes the phosphorylation of SR proteins, which are a conserved family of splicing factors that contain a domain rich in arginine and serine repeats. SR proteins play important roles in const
Externí odkaz:
https://doaj.org/article/a3d1cf2d127e48568e7e7049c2934cf3
Autor:
William K Hu, Rozanne M. Sandri-Goldin, Michele Y Wu, Alexander P. Golovanov, A. Paul Mould, Richard B. Tunnicliffe, Edward A. McKenzie, Colin Levy
Publikováno v:
mBio
mBio, Vol 10, Iss 5 (2019)
mBio, Vol 10, Iss 5, p e02551-19 (2019)
Tunnicliffe, R B, Hu, W K, Wu, M Y, Levy, C, Mould, A P, McKenzie, E A, Sandri-Goldin, R M & Golovanov, A P 2019, ' Molecular Mechanism of SR Protein Kinase 1 Inhibition by the Herpes Virus Protein ICP27 ', mBio, vol. 10, no. 5 . https://doi.org/10.1128/mBio.02551-19
mBio, Vol 10, Iss 5 (2019)
mBio, Vol 10, Iss 5, p e02551-19 (2019)
Tunnicliffe, R B, Hu, W K, Wu, M Y, Levy, C, Mould, A P, McKenzie, E A, Sandri-Goldin, R M & Golovanov, A P 2019, ' Molecular Mechanism of SR Protein Kinase 1 Inhibition by the Herpes Virus Protein ICP27 ', mBio, vol. 10, no. 5 . https://doi.org/10.1128/mBio.02551-19
Serine arginine (SR) proteins are a family of mRNA regulatory proteins that can modulate spliceosome association with different splice sites and therefore regulate alternative splicing. Phosphorylation within SR proteins is necessary for splice-site
Autor:
Andrés J. García, Yunfeng Chen, Lining Ju, Steve Park, Martin J. Humphries, Paul Mould, Cheng Zhu, Fang Kong, Zhenhai Li
Publikováno v:
Biophysical Journal. 118:162a
Autor:
Niklas Arnberg, Linda Sandblad, B. David Persson, Yoshikazu Takada, Jason Gall, Lynn M. Schnapp, Jyrki Heino, Lars Frängsmyr, A. Paul Mould, Annelie Olofsson, Anandi Rajan
Publikováno v:
Scientific reports, vol 8, iss 1
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports
The enteric species F human adenovirus types 40 and 41 (HAdV-40 and -41) are the third most common cause of infantile gastroenteritis in the world. Knowledge about HAdV-40 and -41 cellular infection is assumed to be fundamentally different from that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97739e1ae78a5df5c2c8ff0de437706
https://escholarship.org/uc/item/2jx6j8p4
https://escholarship.org/uc/item/2jx6j8p4
Extracellular Histones Inhibit Complement Activation through Interacting with Complement Component 4
Autor:
Simon T. Abrams, Cheng Hock Toh, Guozheng Wang, Paul Mould, Stephen E. Christmas, Yasir Alhamdi, Yasir Qaddoori
Publikováno v:
JOURNAL OF IMMUNOLOGY
Complement activation leads to membrane attack complex formation, which can lyse not only pathogens but also host cells. Histones can be released from the lysed or damaged cells and serve as a major type of damage-associated molecular pattern, but th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabb5e7b3dfaef30fb119fedcc8418b1
http://livrepository.liverpool.ac.uk/3033100/1/67738_2_merged_1523562639.pdf
http://livrepository.liverpool.ac.uk/3033100/1/67738_2_merged_1523562639.pdf
Autor:
Richard B, Tunnicliffe, Michael P, Lockhart-Cairns, Colin, Levy, A Paul, Mould, Thomas A, Jowitt, Hilary, Sito, Clair, Baldock, Rozanne M, Sandri-Goldin, Alexander P, Golovanov
Publikováno v:
Nucleic Acids Research
The transcription factor ICP4 from herpes simplex virus has a central role in regulating the gene expression cascade which controls viral infection. Here we present the crystal structure of the functionally essential ICP4 DNA binding domain in comple
Autor:
Andrés J. García, A. Paul Mould, Zhenhai Li, William M. Parks, Martin J. Humphries, David W. Dumbauld, Fang Kong, Cheng Zhu
Publikováno v:
Molecular Cell. 49:1060-1068
Cells regulate adhesion in response to internally generated and externally applied forces. Integrins connect the extracellular matrix to the cytoskeleton and provide cells with mechanical anchorages and signaling platforms. Here we show that cyclic f
Autor:
Deepankar, Gahloth, Colin, Levy, Graham, Heaven, Flavia, Stefani, Lydia, Wunderley, Paul, Mould, Matthew J, Cliff, Jordi, Bella, Alistair J, Fielding, Philip, Woodman, Lydia, Tabernero
Publikováno v:
Structure(London, England:1993)
Summary Endosomal sorting complexes required for transport (ESCRTs) are essential for ubiquitin-dependent degradation of mitogenic receptors, a process often compromised in cancer pathologies. Sorting of ubiquinated receptors via ESCRTs is controlled