Zobrazeno 1 - 10
of 10
pro vyhledávání: '"A. P. N. A. de Porto"'
Autor:
Alex F de Vos, Mark C Dessing, Adriana J J Lammers, Alexander P N A de Porto, Sandrine Florquin, Onno J de Boer, Regina de Beer, Sanne Terpstra, Hester J Bootsma, Peter W Hermans, Cornelis van 't Veer, Tom van der Poll
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118181 (2015)
Toll-like receptors (TLR) and the downstream adaptor protein MyD88 are considered crucial for protective immunity during bacterial infections. Streptococcus (S.) pneumoniae is a human respiratory pathogen and a large majority of clinical pneumococcal
Externí odkaz:
https://doaj.org/article/d80b3c2742ac4e1081d1dc30e8b62baf
Autor:
Zhe, Liu, Alexander P N A, De Porto, Regina, De Beer, Joris J T H, Roelofs, Onno J, De Boer, Sandrine, Florquin, Cornelis, Van't Veer, Rudi W, Hendriks, Tom, Van der Poll, Alex F, De Vos
Publikováno v:
Journal of innate immunity.
Humans with dysfunctional Bruton's tyrosine kinase (Btk) are highly susceptible to bacterial infections. Compelling evidence indicates that Btk is essential for B cell-mediated immunity, whereas its role in myeloid cell-mediated immunity against infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8269802d2fc96fc189a480e86076cf6b
https://pubmed.ncbi.nlm.nih.gov/35537415
https://pubmed.ncbi.nlm.nih.gov/35537415
Autor:
Sandrine Florquin, Onno J. de Boer, Tom van der Poll, Zhe Liu, Alex F. de Vos, Regina de Beer, Rudi W. Hendriks, Alexander P. N. A. de Porto
Publikováno v:
Molecular Medicine, Vol 25, Iss 1, Pp 1-10 (2019)
Molecular Medicine
Molecular medicine (Cambridge, Mass.), 25(1). Feinstein Institute for Medical Research
Molecular Medicine, 25:Unsp 3. Feinstein Institute for Medical Research
Molecular Medicine
Molecular medicine (Cambridge, Mass.), 25(1). Feinstein Institute for Medical Research
Molecular Medicine, 25:Unsp 3. Feinstein Institute for Medical Research
Background Streptococcus pneumoniae is a major causative agent in community-acquired pneumonia and sepsis. Overwhelming lung inflammation during pneumococcal pneumonia may hamper lung function. Ibrutinib is an irreversible inhibitor of Bruton’s tyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c42ede7d9bd7ab9e51eb758044107d
http://link.springer.com/article/10.1186/s10020-018-0069-7
http://link.springer.com/article/10.1186/s10020-018-0069-7
Autor:
Sandrine Florquin, Alex F. de Vos, Theodora A. M. Claushuis, Rudi W. Hendriks, Joris J. T. H. Roelofs, Regina de Beer, Tom van der Poll, Lieve E. H. van der Donk, Alexander P. N. A. de Porto, Cornelis van 't Veer, Onno J. de Boer
Publikováno v:
Thrombosis and Haemostasis, 119(6), 930-940. Georg Thieme Verlag
Thrombosis and haemostasis, 119(6), 930-940. Schattauer GmbH
Thrombosis and haemostasis, 119(6), 930-940. Schattauer GmbH
Platelet Bruton's tyrosine kinase (Btk) is an essential signalling protein for the collagen receptor glycoprotein VI (GPVI) and podoplanin receptor C-type-lectin-like receptor-2, which are platelet receptors implicated in the maintenance of vascular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d173b81001c772538aa7f3a17f57610b
https://doi.org/10.1055/s-0039-1681046
https://doi.org/10.1055/s-0039-1681046
Autor:
Onno J. de Boer, Sanne Terpstra, Tom van der Poll, Sandrine Florquin, Mark C. Dessing, Alex F. de Vos, Regina de Beer, Alexander P. N. A. de Porto, Miriam H. P. van Lieshout, Cornelis van 't Veer
Publikováno v:
European Journal of Immunology, 48(1), 66-79. Wiley-VCH Verlag
European journal of immunology, 48(1), 66-79. Wiley-VCH Verlag
European journal of immunology, 48(1), 66-79. Wiley-VCH Verlag
Streptococcus (S.) pneumoniae is the most common cause of community-acquired pneumonia. The Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, consisting of NLRP3, ASC (the adaptor apoptosis-associated speck-like protein contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25bcbfb5e1a7e28d58e05ca1d70f88d
https://doi.org/10.1002/eji.201646554
https://doi.org/10.1002/eji.201646554
Autor:
Jan van Marle, Joost B. L. Hoekstra, J. Carel Goslings, Ester M. M. van Leeuwen, Ineke J. M. ten Berge, Peter Speelman, Roelof J. Bennink, A. J. Jolanda Lammers, Bart J. Biemond, Alexander P. N. A. de Porto
Publikováno v:
American journal of hematology, 87(5), 484-489. Wiley-Liss Inc.
Asplenic patients are at risk for pneumococcal sepsis. Patients with hyposplenic function, such as associated with sickle cell disease (SCD), are also at risk. However, tests to assess splenic function are either unavailable or lacking standardizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946275218556fb8410ae6a886fc69aec
https://doi.org/10.1002/ajh.23154
https://doi.org/10.1002/ajh.23154
Autor:
Onno J. de Boer, Peter W. M. Hermans, Tom van der Poll, Sandrine Florquin, Hester J. Bootsma, Alexander P. N. A. de Porto, A. J. J. Lammers
Publikováno v:
Immunobiology, 216, 863-70
Immunobiology, 216, 8, pp. 863-70
Immunobiology, 216(8), 863-870. Urban und Fischer Verlag GmbH und Co. KG
Immunobiology, 216, 8, pp. 863-70
Immunobiology, 216(8), 863-870. Urban und Fischer Verlag GmbH und Co. KG
Item does not contain fulltext Patients without a spleen are susceptible for overwhelming sepsis with Streptococcus pneumoniae. We investigated the relative contribution of the pneumococcal capsule in the reduced host defense after splenectomy. Sham-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c49e9f33ef49b4f1bc0e29a1d35b6b
https://doi.org/10.1016/j.imbio.2011.02.004
https://doi.org/10.1016/j.imbio.2011.02.004
Autor:
Joris Koetsveld, Cornelis J.F. Van Noorden, Daniëlle M. Voorend, Temo Barwari, Alexander P. N. A. de Porto, Geeske van Rooijen, Jacqueline M. Lankelma, Anne H van der Spek
Publikováno v:
Life Sciences. 86:225-233
Cathepsin L a cysteine protease, is considered to be a potential therapeutic target in cancer treatment. Proteases are involved in the development and progression of cancer. Inhibition of activity of specific proteases may slow down cancer progressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8611c561ee038bb390228d6cb5622d7
https://doi.org/10.1016/j.lfs.2009.11.016
https://doi.org/10.1016/j.lfs.2009.11.016
Autor:
Joost B. L. Hoekstra, I. J. M. ten Berge, A. J. J. Lammers, A. P. N. A. de Porto, Peter Speelman, Roelof J. Bennink
Publikováno v:
European Journal of Clinical Microbiology & Infectious Diseases
European journal of clinical microbiology & infectious diseases, 29(12), 1465-1473. Springer Verlag
European journal of clinical microbiology & infectious diseases, 29(12), 1465-1473. Springer Verlag
Hyposplenic patients are at risk of overwhelming post-splenectomy infection (OPSI), which carries mortality of up to 70%. Therefore, preventive measures are warranted. However, patients with diminished splenic function are difficult to identify. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e2aba9964b37a8c5c76887b5e443ac
https://doi.org/10.1007/s10096-010-1049-1
https://doi.org/10.1007/s10096-010-1049-1
Autor:
Tom van der Poll, Sandrine Florquin, Alexander P. N. A. de Porto, Onno J. de Boer, A. J. J. Lammers
Publikováno v:
BMC infectious diseases, 12(1). BioMed Central
BMC Infectious Diseases
BMC Infectious Diseases, 12, pp. 139-139
BMC Infectious Diseases, Vol 12, Iss 1, p 139 (2012)
BMC Infectious Diseases, 12, 139-139
BMC Infectious Diseases
BMC Infectious Diseases, 12, pp. 139-139
BMC Infectious Diseases, Vol 12, Iss 1, p 139 (2012)
BMC Infectious Diseases, 12, 139-139
Background Asplenic individuals are susceptible for overwhelming infection with Streptococcus pneumoniae, carrying a high mortality. Although Toll-like receptor (TLR)-2 is considered the major receptor for Gram-positive bacteria in innate immunity, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba915c9b943b70ac633612e79efa31f2
https://pure.amc.nl/en/publications/the-role-of-tlr2-in-the-host-response-to-pneumococcal-pneumonia-in-absence-of-the-spleen(f06ea567-77c9-4332-a0d1-cbaa19bd944c).html
https://pure.amc.nl/en/publications/the-role-of-tlr2-in-the-host-response-to-pneumococcal-pneumonia-in-absence-of-the-spleen(f06ea567-77c9-4332-a0d1-cbaa19bd944c).html
