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Akademický článek

Proteo-metabolomics and patient tumor slice experiments point to amino acid centrality for rewired mitochondria in fibrolamellar carcinoma

Autor: Donald Long, Jr., Marina Chan, Mingqi Han, Zeal Kamdar, Rosanna K. Ma, Pei-Yin Tsai, Adam B. Francisco, Joeva Barrow, David B. Shackelford, Mark Yarchoan, Matthew J. McBride, Lukas M. Orre, Nathaniel M. Vacanti, Taranjit S. Gujral, Praveen Sethupathy

Publikováno v: Cell Reports Medicine, Vol 5, Iss 9, Pp 101699- (2024)

Summary: Fibrolamellar carcinoma (FLC) is a rare, lethal, early-onset liver cancer with a critical need for new therapeutics. The primary driver in FLC is the fusion oncoprotein, DNAJ-PKAc, which remains challenging to target therapeutically. It is c

Externí odkaz: https://doaj.org/article/5fee8c91d0e84541891ec3ad5b4cbeeb

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Akademický článek

Sensitivity of classification criteria from time of diagnosis in an incident systemic lupus erythematosus cohort: a population-based study from Norway

Autor: Øyvind Molberg, Karoline Lerang, Cathrine Brunborg, Hilde Haukeland, Helga Sanner, Antonela Botea, Anniken Orre, Nenad Damjanic, Sigrid Reppe Moe, Gro Årthun Wivestad, Heidi Kverneggen Øvreås, Thea Bjerkestrand Bøe, Garen Torhild

Publikováno v: RMD Open, Vol 10, Iss 3 (2024)

Objectives To compare the sensitivity of 2019 European Alliance of Associations for Rheumatology/American College of Rheumatology (EULAR/ACR) classification criteria against 1997 ACR criteria for systemic lupus erythematosus (SLE), for incident SLE c

Externí odkaz: https://doaj.org/article/345fa97c91e346f4b88e889f55a2cdfc

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Akademický článek

Delineating functional and molecular impact of ex vivo sample handling in precision medicine

Autor: Nona Struyf, Albin Österroos, Mattias Vesterlund, Cornelia Arnroth, Tojo James, Stephanie Sunandar, Georgios Mermelekas, Anna Bohlin, Kerstin Hamberg Levedahl, Sofia Bengtzén, Rozbeh Jafari, Lukas M. Orre, Janne Lehtiö, Sören Lehmann, Päivi Östling, Olli Kallioniemi, Brinton Seashore-Ludlow, Tom Erkers

Publikováno v: npj Precision Oncology, Vol 8, Iss 1, Pp 1-7 (2024)

Abstract Consistent handling of samples is crucial for achieving reproducible molecular and functional testing results in translational research. Here, we used 229 acute myeloid leukemia (AML) patient samples to assess the impact of sample handling o

Externí odkaz: https://doaj.org/article/b137e1c0bbc24a2a9826fbbf5bd104d4

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Akademický článek

Domination, Collaboration and Conflict in Cabo Delgado's History of Extractivism

Autor: João Feijó, Aslak Orre

Publikováno v: Kronos, Vol 50, Iss 1, Pp 1-29 (2024)

A long history of extractive industries and activities have shaped the societies of northern Mozambique, and the Cabo Delgado province in particular. For centuries, the growing international demand on local resources had a great impact on the norther

Externí odkaz: https://doaj.org/article/0869456a431b4a0bbb3fbb61ec30f575

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Tunable quantum interference using a topological source of indistinguishable photon pairs

Autor: Mittal, Sunil, Orre, Venkata Vikram, Goldschmidt, Elizabeth A., Hafezi, Mohammad

Publikováno v: Nature Photonics, 15, 542-548 (2021)

Sources of quantum light, in particular correlated photon pairs that are indistinguishable in all degrees of freedom, are the fundamental resource that enables continuous-variable quantum computation and paradigms such as Gaussian boson sampling. Nan

Externí odkaz: http://arxiv.org/abs/2006.03084

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Akademický článek

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