Zobrazeno 1 - 10
of 97
pro vyhledávání: '"A. Obarska-Kosinska"'
Autor:
Maximilian Seidel, Natalie Romanov, Agnieszka Obarska-Kosinska, Anja Becker, Nayara Trevisan Doimo de Azevedo, Jan Provaznik, Sankarshana R. Nagaraja, Jonathan J. M. Landry, Vladimir Benes, Martin Beck
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Various cellular quality control mechanisms support proteostasis. While, ribosome-associated chaperones prevent the misfolding of nascent chains during translation, importins were shown to prevent the aggregation of specific cargoes in a pos
Externí odkaz:
https://doaj.org/article/55dc045fc9ed44c1b929ae9a590b88c8
Autor:
Zapp, Christopher, Obarska-Kosinska, Agnieszka, Rennekamp, Benedikt, Mercadante, Davide, Barayeu, Uladzimir, Dick, Tobias P., Denysenkov, Vasyl, Prisner, Thomas, Bennati, Marina, Daday, Csaba, Kappl, Reinhard, Gräter, Frauke
As established nearly a century ago, mechanoradicals originate from homolytic bond scission in polymers. The existence, nature and biological relevance of mechanoradicals in proteins, instead, are unknown. We here show that mechanical stress on colla
Externí odkaz:
http://arxiv.org/abs/1910.12190
Akademický článek
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Autor:
Christopher Zapp, Agnieszka Obarska-Kosinska, Benedikt Rennekamp, Markus Kurth, David M. Hudson, Davide Mercadante, Uladzimir Barayeu, Tobias P. Dick, Vasyl Denysenkov, Thomas Prisner, Marina Bennati, Csaba Daday, Reinhard Kappl, Frauke Gräter
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
The existence, nature and biological relevance of mechanoradicals in proteins are unknown. Here authors show that mechanical stress on collagen produces radicals and subsequently reactive oxygen species and suggest that collagen I evolved as a radica
Externí odkaz:
https://doaj.org/article/50b8db94c94742b2bea4990163c8a11d
Autor:
Miao Yu, Maziar Heidari, Sofya Mikhaleva, Piau Siong Tan, Sara Mingu, Hao Ruan, Christopher D. Reinkemeier, Agnieszka Obarska-Kosinska, Marc Siggel, Martin Beck, Gerhard Hummer, Edward A. Lemke
Publikováno v:
Nature
The approximately 120 MDa mammalian nuclear pore complex (NPC) acts as a gatekeeper for the transport between the nucleus and cytosol1. The central channel of the NPC is filled with hundreds of intrinsically disordered proteins (IDPs) called FG-nucle
Akademický článek
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Autor:
Sven Fischer, Jérôme Bürgi, Shiran Gabay-Maskit, Renate Maier, Thomas Mastalski, Eden Yifrach, Agnieszka Obarska-Kosinska, Markus Rudowitz, Ralf Erdmann, Harald W. Platta, Matthias Wilmanns, Maya Schuldiner, Einat Zalckvar, Silke Oeljeklaus, Friedel Drepper, Bettina Warscheid
Publikováno v:
Biological Chemistry. 404:135-155
Peroxisomes are organelles with vital functions in metabolism and their dysfunction is associated with human diseases. To fulfill their multiple roles, peroxisomes import nuclear-encoded matrix proteins, most carrying a peroxisomal targeting signal (
Autor:
Seidel, Maximilian, Romanov, Natalie, Obarska-Kosinska, Agnieszka, Becker, Anja, Azevedo, Nayara, Provaznik, Jan, Ranebennuru Nagaraja, Sankarshana, Landry, Jontathan, Benes, Vladimir, Beck, Martin
Various cellular quality control mechanisms support proteostasis. While, ribosome-associated chaperones prevent misfolding of nascent chains during translation, importins were shown to prevent the aggregation of specific cargoes in a post-translation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7caf6bd60eec0561ee3516a33affda7f
Akademický článek
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Publikováno v:
Biophys J
Biophysical Journal
Biophysical Journal
Type I collagen is the main structural component of many tissues in the human body. It provides excellent mechanical properties to connective tissue and acts as a protein interaction hub. There is thus a wide interest in understanding the properties