Zobrazeno 1 - 10
of 11
pro vyhledávání: '"A. O. Durnova"'
Publikováno v:
Bulletin of Experimental Biology and Medicine. 159:164-167
We analyzed the effect of dipeptide Glu-Trp and isovaleroyl-Glu-Trp in concentrations of 0.2, 2 and 20 μg/ml and Actovegin preparation on functional activity of human skin fibroblasts. Dipeptides, especially Glu-Trp, produce a stimulating effect on
Autor:
V. Kh. Khavinson, S. I. Tarnovskaya, A. O. Durnova, R. S. Umnov, Natalia Linkova, E. V. Elashkina
Publikováno v:
Bulletin of Experimental Biology and Medicine. 157:77-80
Peptides Glu-Asp-Arg and Lys-Glu-Asp stimulate serotonin expression in aging cultures of brain cortex cells. Peptide regulation of 5-tryptophan hydroxylase gene encoding the enzyme involved in serotonin synthesis was demonstrated by the molecular doc
Autor:
S. I. Tarnovskaya, Natalia Linkova, A. V. Dudkov, A. O. Durnova, T. V. Kvetnaya, V. Kh. Khavinson, N. N. Sevost’yanova
Publikováno v:
Advances in Gerontology. 3:220-224
In this study, the molecular mechanisms of pancreoprotective action of the tetrapeptide H-Lys-Glu-Asp-Trp-NH2 in aging human pancreatic cells have been investigated. It has been established that the tetrapeptide under study increases the expression o
Autor:
V Kh, Khavinson, S I, Tarnovskaia, N S, Lin'kova, V O, Poliakova, A O, Durnova, T E, Nichik, I M, Kvetnoĭ, M M, D'iakonov, P P, Iakutseni
Publikováno v:
Advances in gerontology = Uspekhi gerontologii. 27(4)
The mechanism of geroprotective effect of peptides AED and EDL was studied in ageing renal cell culture. Peptide AED and EDL increase cell proliferation, decreasing expression of marker of aging p16, p21, p53 and increasing expression of SIRT-6 in yo
Autor:
V. Kh. Khavinson, V. O. Polyakova, I. M. Kvetnoi, Natalia Linkova, T. E. Nichik, A. O. Durnova
Publikováno v:
Bulletin of experimental biology and medicine. 157(2)
We studied the effect of polypeptide complex isolated from calf kidney and short peptides T-31 (AED) and T-35 (EDL) on the expression of signaling molecules, markers of cell renewal (Ki-67, p53), remodeling of the extracellular matrix (MMP-14), and i
Publikováno v:
Bulletin of experimental biology and medicine. 158(1)
We studied molecular mechanisms of the vasoprotective effects of tripeptide T-38 and dipeptide RR-1. Short peptides T-38 and the RR-1 activate the processes of cell renewal in organotypic and dissociated cultures of vascular cells during aging by inc
Autor:
V Kh, Khavinson, N N, Sevost'ianova, A O, Durnova, N S, Lin'kova, S I, Tarnovskaia, A V, Dudkov, T V, Kvetnaia
Publikováno v:
Advances in gerontology = Uspekhi gerontologii. 25(4)
In this study the molecular mechanisms of pancreoprotective action of researched tetrapeptide H-Lys-Glu-Asp-Trp-NH2 in aging pancreatic cells of a human were investigated. It is established that the studied tetrapeptide increases the expression of ma
Publikováno v:
Bulletin of experimental biology and medicine. 157(3)
The molecular mechanism of atherosclerosis is based on decreased expression of signal molecules connexin (Cx37 and Cx40), vascular endothelial growth factor (VEGF), and proliferative protein Ki-67, which characterize the processes of cell–cell inte
Autor:
Natalia Linkova, Igor M. Kvetnoy, R. I. Abdulragimov, A. V. Kostylev, A. O. Durnova, V. O. Polyakova, N. N. Sevostianova, N. A. Chervyakova, V. H. Khavinson
Publikováno v:
Bulletin of experimental biology and medicine. 154(4)
We studied molecular mechanisms of immunoprotective effects of two dipeptides, AB-O and R-1, on cultured human and rat thymic cells. Both dipeptides were shown to increase the expression of lymphocyte differentiation marker CD5 in thymic cells. Dipep
Autor:
V. O. Polyakova, G. H. Tolibova, Natalia Linkova, A. O. Durnova, T. V. Kvetnaia, I. M. Kvetnoy, S. I. Tarnovskaya, V. Kh. Khavinson
Publikováno v:
Bulletin of experimental biology and medicine. 154(4)
Expression of differentiation markers was found to be reduced during ageing of pancreatic cells. Tetrapeptide pancragen stimulates the expression of differentiation factors of acinar (Pdx1, Ptfl a) and islet of Langerhans (Pdx1, Pax6, Pax4, Foxa2, NK