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Akademický článek

Clostridium sporogenes-derived metabolites protect mice against colonic inflammation

Publikováno v: Gut Microbes, Vol 16, Iss 1 (2024)

Gut microbiota-derived metabolites play a pivotal role in the maintenance of intestinal immune homeostasis. Here, we demonstrate that the human commensal Clostridium sporogenes possesses a specific metabolic fingerprint, consisting predominantly of t

Externí odkaz: https://doaj.org/article/97ed57a0291145d689511c9029b8a47d

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Akademický článek

A Novel Approach for Glioblastoma Treatment by Combining Apoptosis Inducers (TMZ, MTX, and Cytarabine) with E.V.A. (Eltanexor, Venetoclax, and A1210477) Inhibiting XPO1, Bcl-2, and Mcl-1

Autor: Kai Zhao, Madita Braun, Leonie Meyer, Katharina Otte, Hartmann Raifer, Frederik Helmprobst, Vincent Möschl, Axel Pagenstecher, Hans Urban, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jelena Pesek, Bernhard Watzer, Wolfgang A. Nockher, R. Verena Taudte, Andreas Neubauer, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch

Publikováno v: Cells, Vol 13, Iss 7, p 632 (2024)

Adjuvant treatment for Glioblastoma Grade 4 with Temozolomide (TMZ) inevitably fails due to therapeutic resistance, necessitating new approaches. Apoptosis induction in GB cells is inefficient, due to an excess of anti-apoptotic XPO1/Bcl-2-family pro

Externí odkaz: https://doaj.org/article/7779d674787040b28c0fded66adc1aba

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Akademický článek

Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK‐STAT signaling in macrophages by perturbing lipid raft structures

Autor: Mohamad K. Hammoud, Raimund Dietze, Jelena Pesek, Florian Finkernagel, Annika Unger, Tim Bieringer, Andrea Nist, Thorsten Stiewe, Aditya M. Bhagwat, Wolfgang Andreas Nockher, Silke Reinartz, Sabine Müller‐Brüsselbach, Johannes Graumann, Rolf Müller

Publikováno v: Molecular Oncology, Vol 16, Iss 17, Pp 3146-3166 (2022)

Survival of ovarian carcinoma is associated with the abundance of immunosuppressed CD163highCD206high tumor‐associated macrophages (TAMs) and high levels of arachidonic acid (AA) in the tumor microenvironment. Here, we show that both associations a

Externí odkaz: https://doaj.org/article/b07760c30d844b4981bdc57ee195b2a3

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Akademický článek

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Akademický článek

Cell type‐selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment

Autor: Silke Reinartz, Sonja Lieber, Jelena Pesek, Dominique T. Brandt, Alina Asafova, Florian Finkernagel, Bernard Watzer, Wolfgang Andreas Nockher, Andrea Nist, Thorsten Stiewe, Julia M. Jansen, Uwe Wagner, Anne Konzer, Johannes Graumann, Robert Grosse, Thomas Worzfeld, Sabine Müller‐Brüsselbach, Rolf Müller

Publikováno v: Molecular Oncology, Vol 13, Iss 2, Pp 185-201 (2019)

The peritoneal fluid of ovarian carcinoma patients promotes cancer cell invasion and metastatic spread with lysophosphatidic acid (LPA) as a potentially crucial mediator. However, the origin of LPA in ascites and the clinical relevance of individual

Externí odkaz: https://doaj.org/article/e7b07ecf563740a58d0b49e54170b0d7

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Prostacyclin Released by Cancer-Associated Fibroblasts Promotes Immunosuppressive and Pro-Metastatic Macrophage Polarization in the Ovarian Cancer Microenvironment

Autor: Leah Sommerfeld, Isabel Knuth, Florian Finkernagel, Jelena Pesek, Wolfgang A. Nockher, Julia M. Jansen, Uwe Wagner, Andrea Nist, Thorsten Stiewe, Sabine Müller-Brüsselbach, Rolf Müller, Silke Reinartz

Publikováno v: Cancers; Volume 14; Issue 24; Pages: 6154

Metastasis of high-grade ovarian carcinoma (HGSC) is orchestrated by soluble mediators of the tumor microenvironment. Here, we have used transcriptomic profiling to identify lipid-mediated signaling pathways encompassing 41 ligand-synthesizing enzyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1603c9b9ff60dfddfd52ea90c1c5f3b3

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Norepinephrine Inhibits Lipopolysaccharide-Stimulated TNF-α but Not Oxylipin Induction in n-3/n-6 PUFA-Enriched Cultures of Circumventricular Organs

Autor: Fabian Johannes Pflieger, Jacqueline Wolf, Martin Feldotto, Andreas Nockher, Tatjana Wenderoth, Jessica Hernandez, Joachim Roth, Daniela Ott, Christoph Rummel

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8745

Sensory circumventricular organs (sCVOs) are pivotal brain structures involved in immune-to-brain communication with a leaky blood–brain barrier that detect circulating mediators such as lipopolysaccharide (LPS). Here, we aimed to investigate the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d8c87e504e3eeab4d3f54e10ad42e7d

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