Zobrazeno 1 - 10
of 100
pro vyhledávání: '"A. N. Tse"'
Publikováno v:
European Journal of Clinical Pharmacology; Jan2024, Vol. 80 Issue 1, p105-113, 9p
Autor:
Gary K. Schwartz, Thomas G. Gesner, Barbara Hibner, Daniel E. Lopes de Menezes, Zhi Jie Ni, Edward J. Moler, Sylvia Ma, Millicent Embry, Kim Aardalen, Haider Cheema, Tahir Sheikh, Katherine G. Rendahl, Archie N. Tse
Supplementary Material 2 from CHIR-124, a Novel Potent Inhibitor of Chk1, Potentiates the Cytotoxicity of Topoisomerase I Poisons In vitro and In vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46416a73e71dfa93da660642c1a2b01
https://doi.org/10.1158/1078-0432.22440615
https://doi.org/10.1158/1078-0432.22440615
Autor:
Gary K. Schwartz, David Kelsen, Merrill J. Egorin, Nian Wu, Katia Manova-Todorova, Karen Brown, Robert Lefkowitz, Robert Maki, Ki Chung, Eileen O'Reilly, Caroll Tipian, Janet Mui, Richard Carvajal, Rachel Sikorski, Tahir Sheikh, Manish Shah, Mithat Gonen, David S. Klimstra, Archie N. Tse
Supplementary Data from A Phase 1 Dose-Escalation Study of Irinotecan in Combination with 17-Allylamino-17-Demethoxygeldanamycin in Patients with Solid Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd85d8ed7d6a9cc4d82a437c698b902
https://doi.org/10.1158/1078-0432.22439293.v1
https://doi.org/10.1158/1078-0432.22439293.v1
Autor:
Gary K. Schwartz, Thomas G. Gesner, Barbara Hibner, Daniel E. Lopes de Menezes, Zhi Jie Ni, Edward J. Moler, Sylvia Ma, Millicent Embry, Kim Aardalen, Haider Cheema, Tahir Sheikh, Katherine G. Rendahl, Archie N. Tse
Supplementary Material 1 from CHIR-124, a Novel Potent Inhibitor of Chk1, Potentiates the Cytotoxicity of Topoisomerase I Poisons In vitro and In vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c89c5878c465412e9e40fbb1b3070b1
https://doi.org/10.1158/1078-0432.22440618
https://doi.org/10.1158/1078-0432.22440618
Autor:
Anne M. White, Graeme E. Walker, Archie N. Tse, Karen J. Taylor, Gary K. Schwartz, Christophe Queva, Judith L. Rosenthal, Shannon Ready, Elizabeth Mouchet, Dongfang Liu, James W. Janetka, Candice L. Horn, Heather R. Haye, Stephen Green, Benjamin L. Caleb, Susan Ashwell, Adam M. Sheehy, Michael R. Grondine, Chun Deng, Sonya D. Zabludoff
Insights from cell cycle research have led to the hypothesis that tumors may be selectively sensitized to DNA-damaging agents resulting in improved antitumor activity and a wider therapeutic margin. The theory relies on the observation that the major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52439dea4e01157038ccc6ed534c5058
https://doi.org/10.1158/1535-7163.c.6532059
https://doi.org/10.1158/1535-7163.c.6532059
Autor:
Gary K. Schwartz, Thomas G. Gesner, Barbara Hibner, Daniel E. Lopes de Menezes, Zhi Jie Ni, Edward J. Moler, Sylvia Ma, Millicent Embry, Kim Aardalen, Haider Cheema, Tahir Sheikh, Katherine G. Rendahl, Archie N. Tse
Supplementary Material 3 from CHIR-124, a Novel Potent Inhibitor of Chk1, Potentiates the Cytotoxicity of Topoisomerase I Poisons In vitro and In vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00eaa73d84307010deea6dda4262f8f7
https://doi.org/10.1158/1078-0432.22440612.v1
https://doi.org/10.1158/1078-0432.22440612.v1
Autor:
Gary K. Schwartz, Thomas G. Gesner, Barbara Hibner, Daniel E. Lopes de Menezes, Zhi Jie Ni, Edward J. Moler, Sylvia Ma, Millicent Embry, Kim Aardalen, Haider Cheema, Tahir Sheikh, Katherine G. Rendahl, Archie N. Tse
Purpose: Chk1 kinase is a critical regulator of both S and G2-M phase cell cycle checkpoints in response to DNA damage. This study aimed to evaluate the biochemical, cellular, and antitumor effects of a novel Chk1 inhibitor, CHIR124.Experimental Desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d334fb09b82320385d6b547c5cd44f3
https://doi.org/10.1158/1078-0432.c.6517917.v1
https://doi.org/10.1158/1078-0432.c.6517917.v1
Autor:
Gary K. Schwartz, David Kelsen, Merrill J. Egorin, Nian Wu, Katia Manova-Todorova, Karen Brown, Robert Lefkowitz, Robert Maki, Ki Chung, Eileen O'Reilly, Caroll Tipian, Janet Mui, Richard Carvajal, Rachel Sikorski, Tahir Sheikh, Manish Shah, Mithat Gonen, David S. Klimstra, Archie N. Tse
Purpose: Both heat shock protein 90 (Hsp90) and checkpoint kinase 1 (Chk1) have emerged as novel therapeutic targets. We conducted a phase I study of irinotecan and the Hsp90 inhibitor 17AAG, which can also down-regulate Chk1, in patients with solid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8870e1664fdf7960b4412ae60017f0
https://doi.org/10.1158/1078-0432.c.6516787.v1
https://doi.org/10.1158/1078-0432.c.6516787.v1
Autor:
Anne M. White, Graeme E. Walker, Archie N. Tse, Karen J. Taylor, Gary K. Schwartz, Christophe Queva, Judith L. Rosenthal, Shannon Ready, Elizabeth Mouchet, Dongfang Liu, James W. Janetka, Candice L. Horn, Heather R. Haye, Stephen Green, Benjamin L. Caleb, Susan Ashwell, Adam M. Sheehy, Michael R. Grondine, Chun Deng, Sonya D. Zabludoff
Supplementary Table from AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4f9f1ea3b0312c94742e41e4ddb83c
https://doi.org/10.1158/1535-7163.22485723
https://doi.org/10.1158/1535-7163.22485723
Autor:
Gary K. Schwartz, Archie N. Tse
Supplementary Movie 3 from Potentiation of Cytotoxicity of Topoisomerase I Poison by Concurrent and Sequential Treatment with the Checkpoint Inhibitor UCN-01 Involves Disparate Mechanisms Resulting in Either p53-Independent Clonogenic Suppression or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3eb6bf5bb7aed0170bca02fccf4f9f
https://doi.org/10.1158/0008-5472.22363425
https://doi.org/10.1158/0008-5472.22363425