Zobrazeno 1 - 10
of 2 064
pro vyhledávání: '"A. N. Phillips"'
Autor:
Bingling She, Tara D. Mangal, Margaret L. Prust, Stephanie Heung, Martin Chalkley, Tim Colbourn, Joseph H. Collins, Matthew M. Graham, Britta Jewell, Purava Joshi, Ines Li Lin, Emmanuel Mnjowe, Sakshi Mohan, Margherita Molaro, Andrew N. Phillips, Paul Revill, Robert Manning Smith, Asif U. Tamuri, Pakwanja D. Twea, Gerald Manthalu, Joseph Mfutso-Bengo, Timothy B. Hallett
Publikováno v:
Human Resources for Health, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background To make the best use of health resources, it is crucial to understand the healthcare needs of a population—including how needs will evolve and respond to changing epidemiological context and patient behaviour—and how this comp
Externí odkaz:
https://doaj.org/article/d02b9c20a1fa48a38798f784c13b3756
Autor:
Andrew N Phillips, Kamy Chetty, Lise Jamieson, Naseem Cassim, Brooke E Nichols, Kyra H Grantz, Alvin X Han, Alexandra de Nooy, Lucia Hans, Manuel Pedro da Silva, Lesley E Scott, Wendy S Stevens
Publikováno v:
BMJ Global Health, Vol 9, Iss 12 (2024)
Introduction To ensure there is adequate investment into diagnostics, an understanding of the magnitude of impact and return on investment is necessary. We, therefore, sought to understand the health and economic impacts of the molecular diagnostic p
Externí odkaz:
https://doaj.org/article/a38a0a995a334bd98b4f57f5c219e146
Autor:
Margherita Molaro, Sakshi Mohan, Bingling She, Martin Chalkley, Tim Colbourn, Joseph H Collins, Emilia Connolly, Matthew M Graham, Eva Janoušková, Ines Li Lin, Gerald Manthalu, Emmanuel Mnjowe, Dominic Nkhoma, Pakwanja D Twea, Andrew N Phillips, Paul Revill, Asif U Tamuri, Joseph Mfutso-Bengo, Tara D Mangal, Timothy B Hallett
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 9, p e1012462 (2024)
An efficient allocation of limited resources in low-income settings offers the opportunity to improve population-health outcomes given the available health system capacity. Efforts to achieve this are often framed through the lens of "health benefits
Externí odkaz:
https://doaj.org/article/901fab8880f14c32bb0c545dd82f1047
Autor:
Tom Pan, Chen Dun, Shikai Jin, Mitchell D. Miller, Anastasios Kyrillidis, George N. Phillips Jr.
Publikováno v:
Structural Dynamics, Vol 11, Iss 4, Pp 044701-044701-14 (2024)
Determining the atomic-level structure of a protein has been a decades-long challenge. However, recent advances in transformers and related neural network architectures have enabled researchers to significantly improve solutions to this problem. Thes
Externí odkaz:
https://doaj.org/article/35ebbaec82dd44a9a6ced8b4de52544e
Autor:
Tek Narsingh Malla, Kara Zielinski, Luis Aldama, Sasa Bajt, Denisse Feliz, Brendon Hayes, Mark Hunter, Christopher Kupitz, Stella Lisova, Juraj Knoska, Jose Manuel Martin-Garcia, Valerio Mariani, Suraj Pandey, Ishwor Poudyal, Raymond G. Sierra, Alexandra Tolstikova, Oleksandr Yefanov, Chung Hong Yoon, Abbas Ourmazd, Petra Fromme, Peter Schwander, Anton Barty, Henry N. Chapman, Emina A. Stojkovic, Alexander Batyuk, Sébastien Boutet, George N. Phillips, Lois Pollack, Marius Schmidt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract For decades, researchers have elucidated essential enzymatic functions on the atomic length scale by tracing atomic positions in real-time. Our work builds on possibilities unleashed by mix-and-inject serial crystallography (MISC) at X-ray f
Externí odkaz:
https://doaj.org/article/50042ef4cec14678ac809352eb19f238
Publikováno v:
IUCrJ, Vol 10, Iss 4, Pp 487-496 (2023)
The general de novo solution of the crystallographic phase problem is difficult and only possible under certain conditions. This paper develops an initial pathway to a deep learning neural network approach for the phase problem in protein crystallogr
Externí odkaz:
https://doaj.org/article/5f4e3dbe014048a3be76cba849b381eb
Publikováno v:
PLoS ONE, Vol 19, Iss 12, p e0296540 (2024)
IntroductionMathematical modelling is a commonly utilised tool to predict the impact of policy on health outcomes globally. Given the persistently high levels of maternal and perinatal morbidity and mortality in sub-Saharan Africa, mathematical model
Externí odkaz:
https://doaj.org/article/ff0608dd180a4025b355d3e23d164c99
Publikováno v:
Structural Dynamics, Vol 11, Iss 1, Pp 014702-014702-12 (2024)
Adenylate kinase is a ubiquitous enzyme in living systems and undergoes dramatic conformational changes during its catalytic cycle. For these reasons, it is widely studied by genetic, biochemical, and biophysical methods, both experimental and theore
Externí odkaz:
https://doaj.org/article/452be095b90749f995e0cd79032f1118
Autor:
Bingling She, Tara D Mangal, Anna Y Adjabeng, Tim Colbourn, Joseph H Collins, Eva Janoušková, Ines Li Lin, Emmanuel Mnjowe, Sakshi Mohan, Margherita Molaro, Andrew N Phillips, Paul Revill, Robert Manning Smith, Pakwanja D Twea, Dominic Nkhoma, Gerald Manthalu, Timothy B Hallett
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0290823 (2024)
IntroductionThe COVID-19 pandemic and the restriction policies implemented by the Government of Malawi may have disrupted routine health service utilisation. We aimed to find evidence for such disruptions and quantify any changes by service type and
Externí odkaz:
https://doaj.org/article/809d2f77cddc4caba05f56d384dbbea1
Autor:
Greg Tram, Freda E.-C. Jen, Zachary N. Phillips, John F. Lancashire, Jamie Timms, Jessica Poole, Michael P. Jennings, John M. Atack
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 1 (2024)
ABSTRACT Haemophilus influenzae biogroup aegyptius is the causative agent of Brazilian purpuric fever (BPF), an invasive disease with high mortality, that sporadically manifests in children previously suffering conjunctivitis. Though strains of H. in
Externí odkaz:
https://doaj.org/article/bb3c4b220b9b4758b57325e22dd20940