Genetically encoded intrabody probes for labeling and manipulating AMPA-type glutamate receptors

Autor: Dean J. Kareemo, Christina S. Winborn, Samantha S. Olah, Carley N. Miller, JungMin Kim, Chelsie A. Kadgien, Hannah S. Actor-Engel, Harrison J. Ramsay, Austin M. Ramsey, Jason Aoto, Matthew J. Kennedy

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract Tools for visualizing and manipulating protein dynamics in living cells are critical for understanding cellular function. Here we leverage recently available monoclonal antibody sequences to generate a set of affinity tags for labeling and m

Externí odkaz: https://doaj.org/article/6994164957e4485a81f9f49a4d105b62

Unveiling errors in soil microbial community sequencing: a case for reference soils and improved diagnostics for nanopore sequencing

Autor: Daniel K. Manter, Catherine L. Reardon, Amanda J. Ashworth, Abasiofiok M. Ibekwe, R. Michael Lehman, Jude E. Maul, Daniel N. Miller, Timothy Creed, Patrick M. Ewing, Stanley Park, Thomas F. Ducey, Heather L. Tyler, Kristen S. Veum, Sharon L. Weyers, David B. Knaebel

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)

Abstract The sequencing platform and workflow strongly influence microbial community analyses through potential errors at each step. Effective diagnostics and experimental controls are needed to validate data and improve reproducibility. This cross-l

Externí odkaz: https://doaj.org/article/bcdcbdf86ccc406082fdd8f369c97d6b

Predicting deep infection in pilon and tibial plateau fractures: a secondary analysis of the VANCO and OXYGEN trials

Autor: Archie L. Overmann, MD, Anthony R. Carlini, MS, Robert V. O'Toole, MD, Renan C. Castillo, PhD, Nathan N. O'Hara, PhD, MHA, METRC, Eben A. Carroll, MD, James Brett Goodman, MBA, Martha B. Holden, AAS, AA, Anna N. Miller, MD, Amanda Spraggs-Hughes, PhD, Michael L. Brennan, MD, Paul Tornetta, III, MD, Patrick M. Osborn, MD, Jessica C. Rivera, MD, PhD, Clinton K. Murray, MD, Joseph E. Kimmel, MS, Michael J. Bosse, MD, Joseph R. Hsu, MD, Madhav A. Karunakar, MD, Laurence B. Kempton, MD, Rachel B. Seymour, PhD, Stephen H. Sims, MD, Christine Churchill, MA, Debra L. Sietsema, PhD, RN, Ida Leah Gitajn, MD, MS, Rachel M. Reilly, MD, Robert D. Zura, MD, Cameron Howes, BA, Hassan Mir, MD, MBA, Michael J. Weaver, MD, Marilyn Heng, MD, MPH, Thuan V. Ly, MD, Emily A. Wagstrom, MD, Jerald R. Westberg, MPH, BA, Brian H. Mullis, MD, Jeffrey O. Anglen, MD, Leilani S. Mullis, MD, Karl D. Shively, MD, Todd O. McKinley, MD, Roman M. Natoli, MD, PhD, Anthony Sorkin, MD, Lauren C. Hill, BS, CCRC, Robert A. Hymes, MD, Greg E. Gaski, MD, A. Stephen Malekzadeh, MD, Lolita Ramsey, PhD, RN, Jeff E. Schulman, MD, Cary C. Schwartzbach, MD, Robert A. Sikorski, MD, Olivia C. Lee, MD, Peter C. Krause, MD, Joshua L. Gary, MD, Timothy S. Achor, MD, Andrew Choo, MD, John W. Munz, MD, Sterling J. Boutte, BS, Matthew C. Galpin, CCRC, H. Michael Frisch, MD, Adam M. Kaufman, MD, C. Michael LeCroy, MD, Christopher S. Smith, MD, Alec C. Stall, MD, MPH, Andrea Horne, MA, CCRP, Manjari Joshi, MBBS, Jason W. Nascone, MD, Marcus F. Sciadini, MD, Gerard P. Slobogean, MD, Andrea L. Howe, BS, Roman Hayda, MD, Andrew R. Evans, MD, Stanislaw P. Stawicki, MD, MBA, Thomas R. Wojda, MD, MBA, Michael J. Gardner, MD, Julius A. Bishop, MD, Saqib Rehman, MD, MBA, Cyrus Caroom, MD, Elizabeth Sheridan, MPH, MACPR, Theodore Miclau, MD, Saam Morshed, MD, PhD, Thomas F. Higgins, MD, Justin M. Haller, MD, Clay A. Spitler, MD, Massimo Max Morandi, MD, FACS, Paul Edward Matuszewski, MD, Arun Aneja, MD, PhD, Patrick F. Bergin, MD, Eldrin Bhanat, MD, MPH, Matt L. Graves, MD, John Morellato, MBBS Hons, David Teague, MD, William Ertl, MD, Jaimo Ahn, MD, PhD, Gele B. Moloney, MD, John C. Weinlein, MD, Boris A. Zelle, MD, Animesh Agarwal, MD, Ravi A. Karia, MD, Ashoke Sathy, MD, Drew Sanders, MD, MPH, David B. Weiss, MD, Seth R. Yarboro, MD, Veronica Lester-Ballard, MSN, Eric D. McVey, MEd, CCRP, Reza Firoozabadi, MD, MA, Arman Dagal, MD, FRCA, Conor P. Kleweno, MD, Julie Agel, MA, Paul S. Whiting, MD, Natasha M. Simske, BS, Alexander B. Siy, BS, William T. Obremskey, MD, MPH, Basem Attum, MD, Eduardo J. Burgos, MD, Vamshi Gajari, MBBS, A. Alex Jahangir, MD, Andres Rodriguez-Buitrago, MD, Manish Sethi, MD, Daniel J. Stinner, MD, PhD, Rajesh R. Tummuru, MBBS, MBA, Karen M. Trochez, MA, BS, Jean-Claude G. D'Alleyrand, MD, MSE, Lauren E. Allen, DrPH, Susan C. Collins, MSc, Yanjie Huang, ScM, Tara J. Taylor, MPH

Publikováno v: OTA International, Vol 7, Iss 4 (2024)

Abstract. Objectives:. To develop and validate a prediction model for a deep surgical site infection (SSI) after fixation of a tibial plateau or pilon fracture. Design:. Pooled data from 2 randomized trials (VANCO and OXYGEN). Setting:. Fifty-two US

Externí odkaz: https://doaj.org/article/f526c1bca38a46778b5055dcf59b14aa

Leveraging digital tools to enhance diversity and inclusion in clinical trial recruitment

Autor: Tosin Tomiwa, Erin Wong, Hailey N. Miller, Oluwabunmi Ogungbe, Samuel Byiringiro, Timothy Plante, Cheryl R. Himmelfarb

Publikováno v: Frontiers in Public Health, Vol 12 (2024)

Clinical research is pivotal in assessing the safety and efficacy of new treatments in healthcare. However, the success of such research depends on the inclusion of a diverse and representative participant sample, which is currently lacking. This lac

Externí odkaz: https://doaj.org/article/c494180c9da9484d8d180b7da953ecf0

Sociodemographic predictors of successful screening and subsequent randomization in a digital health hypertension intervention

Autor: Hailey N Miller, Sandy Askew, Miriam B Berger, Elizabeth Trefney, Loneke T Blackman Carr, Melissa C Kay, Cherie Barnes, Qing Yang, Crystal C Tyson, Laura Svetkey, Ryan J Shaw, Dori M Steinberg, Gary G Bennett

Publikováno v: Digital Health, Vol 10 (2024)

Introduction Clinical trials often enroll nonrepresentative participant samples, limiting generalizability of trial findings. The current analysis explores the influences of remote recruitment and screening protocols on participation in a digital hea

Externí odkaz: https://doaj.org/article/728daaa4248b4b6d9b98924ee637658b