Zobrazeno 1 - 10
of 71
pro vyhledávání: '"A. N. Lasseigne"'
Autor:
Emma F. Jones, Timothy C. Howton, Victoria L. Flanary, Amanda D. Clark, Brittany N. Lasseigne
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-16 (2024)
Abstract Alternative splicing (AS) contributes to the biological heterogeneity between species, sexes, tissues, and cell types. Many diseases are either caused by alterations in AS or by alterations to AS. Therefore, measuring AS accurately and effic
Externí odkaz:
https://doaj.org/article/886828797be44df2ac40fc1ae2c4e865
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Alzheimer’s disease is the most common cause of dementia and is characterized by amyloid-β plaques, tau neurofibrillary tangles, and neuronal loss. Although neuronal loss is a primary hallmark of Alzheimer’s disease, it is kn
Externí odkaz:
https://doaj.org/article/8bb2bd0ed74f487fb8fd59b64dc9c11c
Autor:
Jennifer L. Fisher, Elizabeth J. Wilk, Vishal H. Oza, Sam E. Gary, Timothy C. Howton, Victoria L. Flanary, Amanda D. Clark, Anita B. Hjelmeland, Brittany N. Lasseigne
Publikováno v:
FEBS Open Bio, Vol 14, Iss 5, Pp 803-830 (2024)
Drug repurposing is promising because approving a drug for a new indication requires fewer resources than approving a new drug. Signature reversion detects drug perturbations most inversely related to the disease‐associated gene signature to identi
Externí odkaz:
https://doaj.org/article/f40949cccc344b50a5660d71408edfbd
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0296328 (2024)
The SET binding protein 1 (SETBP1) gene encodes a transcription factor (TF) involved in various cellular processes. Variants in SETBP1 can result in three different diseases determined by the introduction (germline vs. somatic) and location of the va
Externí odkaz:
https://doaj.org/article/d9df04adfc8e4ccab895c30f4b66231f
Autor:
Elizabeth J. Wilk, Timothy C. Howton, Jennifer L. Fisher, Vishal H. Oza, Ryan T. Brownlee, Kasi C. McPherson, Hannah L. Cleary, Bradley K. Yoder, James F. George, Michal Mrug, Brittany N. Lasseigne
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-21 (2023)
Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) is one of the most prevalent monogenic human diseases. It is mostly caused by pathogenic variants in PKD1 or PKD2 genes that encode interacting transmembrane proteins polycystin
Externí odkaz:
https://doaj.org/article/a29d831d0f624c96a1f2239ed4a5233e
Publikováno v:
Cancer Reports, Vol 6, Iss 12, Pp n/a-n/a (2023)
Abstract Background Cancer is a complex disease that is the second leading cause of death in the United States. Despite research efforts, the ability to manage cancer and select optimal therapeutic responses for each patient remains elusive. Chromoso
Externí odkaz:
https://doaj.org/article/fc55d8f10ddf4e04996a60fab76d1f83
Publikováno v:
Cancer Reports, Vol 6, Iss 9, Pp n/a-n/a (2023)
Abstract Background Preclinical models like cancer cell lines and patient‐derived xenografts (PDXs) are vital for studying disease mechanisms and evaluating treatment options. It is essential that they accurately recapitulate the disease state of i
Externí odkaz:
https://doaj.org/article/d7dab3e4abaa48a795470fdab801ed58
Publikováno v:
PeerJ, Vol 11, p e15244 (2023)
Genomic instability is an important hallmark of cancer and more recently has been identified in others like neurodegenrative diseases. Chromosomal instability, as a measure of genomic instability, has been used to characterize clinical and biological
Externí odkaz:
https://doaj.org/article/2b7bda82b19e4b839625dc19ae09106b
Autor:
Jennifer L. Fisher, Emma F. Jones, Victoria L. Flanary, Avery S. Williams, Elizabeth J. Ramsey, Brittany N. Lasseigne
Publikováno v:
Biology of Sex Differences, Vol 13, Iss 1, Pp 1-23 (2022)
Highlights Genetic, epigenetic, hormonal, immunological, metabolic, and environmental factors affect sex-biased drug responses. Drug repurposing approaches provide a significant advantage over novel drug development by reducing lengthy and costly cli
Externí odkaz:
https://doaj.org/article/a8821dfe23fd4b169cfc582a6557e6e3
Autor:
Vishal H Oza, Jordan H Whitlock, Elizabeth J Wilk, Angelina Uno-Antonison, Brandon Wilk, Manavalan Gajapathy, Timothy C Howton, Austyn Trull, Lara Ianov, Elizabeth A Worthey, Brittany N Lasseigne
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 1, p e1010749 (2023)
With an increasing amount of biological data available publicly, there is a need for a guide on how to successfully download and use this data. The 10 simple rules for using public biological data are: (1) use public data purposefully in your researc
Externí odkaz:
https://doaj.org/article/e2f1a4d14283452ea313b1f657253d45