Fluid–structure interaction modelling of a positive-displacement Total Artificial Heart

Autor: Joseph Bornoff, Azad Najar, Libera Fresiello, Thomas Finocchiaro, Ina Laura Perkins, Harinderjit Gill, Andrew N. Cookson, Katharine H. Fraser

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract For those suffering from end-stage biventricular heart failure, and where a heart transplantation is not a viable option, a Total Artificial Heart (TAH) can be used as a bridge to transplant device. The Realheart TAH is a four-chamber artifi

Externí odkaz: https://doaj.org/article/834932446ffb481f83c77608cbb18048

MRI-based strain measurements reflect morphological changes following myocardial infarction: A study on the UK Biobank cohort

Autor: Doyin S. Mansell, Eva Sammut, Vito D. Bruno, Raimondo Ascione, Jonathan C. L. Rodrigues, Harinderjit S. Gill, Katharine H. Fraser, Andrew N. Cookson

Publikováno v: Odunmbaku-Mansell, D, Sammut, E, Bruno, V D, Ascione, R, Rodrigues, J C L, Gill, H S, Fraser, K & Cookson, A 2023, ' MRI-based strain measurements reflect morphological changes following myocardial infarction : A study on the UK Biobank cohort ', Journal Of Anatomy, vol. 242, no. 1, pp. 102-111 . https://doi.org/10.1111/joa.13787

In a porcine experimental model of myocardial infarction, a localised, layer-specific, circumferential left ventricular strain metric has been shown to indicate chronic changes in ventricular function post-infarction more strongly than ejection fract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419941de4e9c06777c5ae40c4ab865fa
https://pubmed.ncbi.nlm.nih.gov/36484568

Efficiently Generating Mixing by Combining Differing Small Amplitude Helical Geometries

Autor: Andrew N. Cookson, Denis J. Doorly, Spencer J. Sherwin

Publikováno v: Fluids, Vol 4, Iss 2, p 59 (2019)

Helical geometries have been used in recent years to form cardiovascular prostheses such as stents and shunts. The helical geometry has been found to induce swirling flow, promoting in-plane mixing. This is hypothesised to reduce the formation of thr

Externí odkaz: https://doaj.org/article/d2478f49a742421fac708e2b124538ca

Nicotine binding in human striatum: elevation in schizophrenia and reductions in dementia with Lewy bodies, Parkinson’s disease and Alzheimer’s disease and in relation to neuroleptic medication

Autor: N. Cookson, S. Lloyd, Elaine K. Perry, Ian G. McKeith, M.A. Piggott, J.A. Court, Robert H. Perry, Clive Ballard

Publikováno v: Neuroscience. 98:79-87

Striatal nicotinic acetylcholine receptors with high affinity for nicotinic agonists are involved with the release of a number of neurotransmitters, including dopamine. Previous findings as to whether these receptors are changed in Parkinson's diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc406756ce4ac014f054cd1b9cccd50a
https://doi.org/10.1016/s0306-4522(00)00071-3

A computationally efficient framework for the simulation of cardiac perfusion using a multi-compartment Darcy porous-media flow model

Autor: C, Michler, A N, Cookson, R, Chabiniok, E, Hyde, J, Lee, M, Sinclair, T, Sochi, A, Goyal, G, Vigueras, D A, Nordsletten, N P, Smith

Publikováno v: International journal for numerical methods in biomedical engineering. 29(2)

We present a method to efficiently simulate coronary perfusion in subject-specific models of the heart within clinically relevant time frames. Perfusion is modelled as a Darcy porous-media flow, where the permeability tensor is derived from homogeniz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::64e472e3b6db7c79534c16bc01165e29
https://pubmed.ncbi.nlm.nih.gov/23345266