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3D surface analysis of hippocampal microvasculature in the irradiated brain

Autor: Brianna M. Craver, Sarah N. Benke, Munjal M. Acharya, Charles L. Limoli, Janet E. Baulch, Barrett D. Allen, Nan W. Hultgren

Publikováno v: Environmental and Molecular Mutagenesis. 57:341-349

Cranial irradiation used to control CNS malignancies can also disrupt the vasculature and impair neurotransmission and cognition. Here we describe two distinct methodologies for quantifying early and late radiation injury in CNS microvasculature. Int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b80b350192f4bbc982ecfb1ed7d3a6b0
https://doi.org/10.1002/em.22015

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Potent Antimicrobial Activity of Lipidated Short α,γ-Hybrid Peptides

Autor: Sushil N. Benke, Hirekodathakallu V. Thulasiram, Hosahudya N. Gopi

Publikováno v: ChemMedChem. 12(19)

We are reporting potent antimicrobial activity of alpha,gamma-hybrid lipopeptides constituted with 1:1 alternating alpha- and gamma-amino acids. Along with their potent antimicrobial activity against various Gram positive and Gram negative bacteria,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c719d3ed39e558c1f5453e360023e1
https://pubmed.ncbi.nlm.nih.gov/28834198

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Engineering polypeptide folding through trans double bonds: transformation of miniature β-meanders to hybrid helices

Autor: Sushil N. Benke, K. Muruga Poopathi Raja, Mothukuri Ganesh Kumar, Hosahudya N. Gopi

Publikováno v: Chemical Communications. 51:13397-13399

Utilization of conjugated double bonds to engineer the novel folded miniature β-meander type structures, single step transformation of miniature β-meanders into ααγ(4)-hybrid peptide 10/12-helices using catalytic hydrogenation, their solution an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72cf42ee9b400a46223b2865bab56ce3
https://doi.org/10.1039/c5cc04523a

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Interaction of liposomes bearing a lipophilic doxorubicin prodrug with tumor cells

Autor: G. P. Gaenko, N. R. Kuznetsova, A. N. Benke, Elena L. Vodovozova, Elena V. Svirshchevskaya, I. V. Skripnik, E. N. Zarudnaya, Yu. G. Molotkovskii

Publikováno v: Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology. 7:12-20

When used as nanosized carriers, liposomes enable targeted delivery and decrease systemic toxicity of antitumor agents significantly. However, slow unloading of liposomes inside cells diminishes the treatment efficiency. The problem could be overcome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c79365622dca3481ba7fd0daff745ed7
https://doi.org/10.1134/s1990747812050108

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Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain

Autor: Sarah N. Benke, Amber R. Syage, Audrey L. Park, Nicole N. Chmielewski, Charles L. Limoli, Munjal M. Acharya, Vipan K. Parihar, Ning Ru, Barrett D. Allen, Vahan Martirosian, Janet E. Baulch, Erich Giedzinski

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 17
Baulch, JE; Acharya, MM; Allen, BD; Ru, N; Chmielewski, NN; Martirosian, V; et al.(2016). Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(17), 4836-4841. doi: 10.1073/pnas.1521668113. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1187f13x

Cancer survivors face a variety of challenges as they cope with disease recurrence and a myriad of normal tissue complications brought on by radio- and chemotherapeutic treatment regimens. For patients subjected to cranial irradiation for the control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4cf20512f5d23e4b1897edaaae43dd8
https://escholarship.org/uc/item/1187f13x

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Comparison of simultaneous and pre-irradiation grafting of N-vinylpyrrolidone to cotton-cellulose

Autor: László Wojnárovits, Hamid Mirzadeh, M. Mirzataheri, Judit Borsa, Endre Takacs, N. Benke

Publikováno v: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 265:217-220

Cotton-cellulose samples with modified surface properties were prepared by simultaneous and pre-irradiation grafting methods, respectively, using N -vinylpyrrolidone monomer. In the mutual grafting experiments Mohr salt was used to avoid homopolymer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ab5749f195c7a420073268b9657beda
https://doi.org/10.1016/j.nimb.2007.08.098

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Pre-irradiation grafting of cellulose and slightly carboxymethylated cellulose (CMC) fibres

Autor: Judit Borsa, Endre Takacs, László Wojnárovits, N. Benke

Publikováno v: Radiation Physics and Chemistry. 76:1355-1359

Acrylamide, hydroxypropyl acrylate, hydroxypropyl methacrylate and 2-ethylhexyl methacrylate vinyl monomers were grafted onto cellulose as well as onto cellulose of improved accessibility (slightly carboxymethylated cellulose (CMC)) by the pre-irradi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8f3c1d416ec3f450bec1b7dac16c6a7
https://doi.org/10.1016/j.radphyschem.2007.02.031

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Self-assembly to function: design, synthesis, and broad spectrum antimicrobial properties of short hybrid E-vinylogous lipopeptides

Autor: Prabhakar Lal Srivastava, Sushil N. Benke, Hosahudya N. Gopi, Narem Nagendra, Hirekodathakallu V. Thulasiram, S. Shiva Shankar

Publikováno v: Journal of medicinal chemistry. 56(21)

Nonribosomal E-vinylogous γ-amino acids are widely present in many peptide natural products and have been exploited as inhibitors for serine and cysteine proteases. Here, we are reporting the broad spectrum antimicrobial properties and self-assemble

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc57c5added87e3362bb422d2fd8a92
https://pubmed.ncbi.nlm.nih.gov/24117107

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Prenatal Diagnosis of Circumvallate Placenta and Pregnancy Outcomes

Autor: D. Yvette LaCoursiere, Neha Trivedi, Adanna Anyikam, Andrew D. Hull, Sarah N. Benke, Dolores H. Pretorius

Publikováno v: Obstetrics & Gynecology. 123:98S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1684950b07f1168ec57bfe30e5ef684c
https://doi.org/10.1097/01.aog.0000447440.50738.2c

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A facile synthesis and crystallographic analysis of N-protected β-amino alcohols and short peptaibols

Autor: Hosahudya N. Gopi, Sachitanand M. Mali, Sushil N. Benke, Anupam Bandyopadhyay, Sandip V. Jadhav

Publikováno v: Organic & Biomolecular Chemistry. 9:4182

A facile, efficient and racemization-free method for the synthesis of N-protected β-amino alcohols and peptaibols using N-hydroxysuccinimide active esters is described. Using this method, dipeptide, tripeptide and pentapeptide alcohols were isolated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eed832b34009a51246769c852a5b232
https://doi.org/10.1039/c0ob01226b

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