Zobrazeno 1 - 10
of 69
pro vyhledávání: '"A. N. Beavers"'
Autor:
Joshua Soto Ocaña, Elliot S. Friedman, Orlaith Keenan, Nile U. Bayard, Eileen Ford, Ceylan Tanes, Matthew J. Munneke, William N. Beavers, Eric P. Skaar, Kyle Bittinger, Babette S. Zemel, Gary D. Wu, Joseph P. Zackular
Publikováno v:
mBio, Vol 15, Iss 11 (2024)
ABSTRACT The gut microbiota plays a critical role in human health and disease. Microbial community assembly and succession early in life are influenced by numerous factors. In turn, assembly of this microbial community is known to influence the host,
Externí odkaz:
https://doaj.org/article/aaac615ce2b74ba2a3705d0b2bc73776
Autor:
Jeffrey M. Boyd, Kylie Ryan Kaler, Karla Esquilín-Lebrón, Ashley Pall, Courtney J. Campbell, Mary E. Foley, Gustavo Rios-Delgado, Emilee M. Mustor, Timothy G. Stephens, Hannah Bovermann, Todd M. Greco, Ileana M. Cristea, Valerie J. Carabetta, William N. Beavers, Debashish Bhattacharya, Eric P. Skaar, Lindsey N. Shaw, Timothy L. Stemmler
Publikováno v:
mBio, Vol 15, Iss 11 (2024)
ABSTRACT Iron (Fe) is a trace nutrient required by nearly all organisms. As a result of the demand for Fe and the toxicity of non-chelated cytosolic ionic Fe, regulatory systems have evolved to tightly balance Fe acquisition and usage while limiting
Externí odkaz:
https://doaj.org/article/4f705795294c49deaeb7dd1b2434b571
Autor:
Javiera Norambuena, Hassan Al-Tameemi, Hannah Bovermann, Jisun Kim, William N Beavers, Eric P Skaar, Dane Parker, Jeffrey M Boyd
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1011393 (2023)
To gain a better insight of how Copper (Cu) ions toxify cells, metabolomic analyses were performed in S. aureus strains that lacks the described Cu ion detoxification systems (ΔcopBL ΔcopAZ; cop-). Exposure of the cop- strain to Cu(II) resulted in
Externí odkaz:
https://doaj.org/article/3f1de80caeeb4e4e89cb47459d3ed5dc
Autor:
William N. Beavers, Matthew J. Munneke, Alex R. Stackhouse, Jeffrey A. Freiberg, Eric P. Skaar
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT Aminoglycoside antibiotics rely on the proton motive force to enter the bacterial cell, and facultative anaerobes like Staphylococcus aureus can shift energy generation from respiration to fermentation, becoming tolerant of aminoglycosides.
Externí odkaz:
https://doaj.org/article/d2b7f002f9714c049cf6cabaad2d64bc
Autor:
Lillian J. Juttukonda, William N. Beavers, Daisy Unsihuay, Kwangho Kim, Gleb Pishchany, Kyle J. Horning, Andy Weiss, Hassan Al-Tameemi, Jeffrey M. Boyd, Gary A. Sulikowski, Aaron B. Bowman, Eric P. Skaar
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Metals are essential nutrients that all living organisms acquire from their environment. While metals are necessary for life, excess metal uptake can be toxic; therefore, intracellular metal levels are tightly regulated in bacterial cells. S
Externí odkaz:
https://doaj.org/article/1260e5a12a7c4059be846aa784f59aa4
Autor:
Joseph P. Zackular, Reece J. Knippel, Christopher A. Lopez, William N. Beavers, C. Noel Maxwell, Walter J. Chazin, Eric P. Skaar
Publikováno v:
mSphere, Vol 5, Iss 2 (2020)
ABSTRACT Clostridioides difficile is a spore-forming bacterium that causes severe colitis and is a major public health threat. During infection, C. difficile toxin production results in damage to the epithelium and a hyperinflammatory response. The i
Externí odkaz:
https://doaj.org/article/58e89e011997490d95225cdd11918de3
Autor:
Christopher A. Lopez, William N. Beavers, Andy Weiss, Reece J. Knippel, Joseph P. Zackular, Walter Chazin, Eric P. Skaar
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT The intestines house a diverse microbiota that must compete for nutrients to survive, but the specific limiting nutrients that control pathogen colonization are not clearly defined. Clostridioides difficile colonization typically requires pr
Externí odkaz:
https://doaj.org/article/58d3b414beb14d489a54738e17fe4a93
Autor:
William N. Beavers, Andrew J. Monteith, Venkataraman Amarnath, Raymond L. Mernaugh, L. Jackson Roberts, Walter J. Chazin, Sean S. Davies, Eric P. Skaar
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT Staphylococcus aureus infects every niche of the human host. In response to microbial infection, vertebrates have an arsenal of antimicrobial compounds that inhibit bacterial growth or kill bacterial cells. One class of antimicrobial compoun
Externí odkaz:
https://doaj.org/article/8d48f172b9184d079ef7539080bca2d8
Autor:
Caroline M. Grunenwald, Jacob E. Choby, Lillian J. Juttukonda, William N. Beavers, Andy Weiss, Victor J. Torres, Eric P. Skaar
Publikováno v:
mBio, Vol 10, Iss 1 (2019)
ABSTRACT Manganese (Mn) is an essential micronutrient critical for the pathogenesis of Staphylococcus aureus, a significant cause of human morbidity and mortality. Paradoxically, excess Mn is toxic; therefore, maintenance of intracellular Mn homeosta
Externí odkaz:
https://doaj.org/article/60f1432fa64645f791d315ca384e153c
Autor:
Zachery R. Lonergan, Brittany L. Nairn, Jiefei Wang, Yen-Pang Hsu, Laura E. Hesse, William N. Beavers, Walter J. Chazin, Jonathan C. Trinidad, Michael S. VanNieuwenhze, David P. Giedroc, Eric P. Skaar
Publikováno v:
Cell Reports, Vol 26, Iss 8, Pp 2009-2018.e6 (2019)
Summary: Acinetobacter baumannii is an important nosocomial pathogen capable of causing wound infections, pneumonia, and bacteremia. During infection, A. baumannii must acquire Zn to survive and colonize the host. Vertebrates have evolved mechanisms
Externí odkaz:
https://doaj.org/article/20909d2dfa1a429390eb5ab0218db2a6