Zobrazeno 1 - 10
of 45
pro vyhledávání: '"A. Muralikrishna Rao"'
Autor:
Raghavendra Rao, Vemuganti L *, Muralikrishna Rao, Adibhatla, Dogan, Aclan, Bowen, Kellie K, Hatcher, James, Rothstein, Jeffrey D, Dempsey, Robert J
Publikováno v:
In Neurochemistry International 2000 36(6):531-537
Publikováno v:
Brain Research. 893:268-272
Ten min forebrain ischemia/1-day reperfusion resulted in significant decreases in total phosphatidylcholine (PtdCho), phosphatidylinositol (PtdIns), and cardiolipin in gerbil hippocampus. CDP-choline restored cardiolipin levels, arachidonic acid cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ab9f53a4f3dff7652fa231d79c4068
https://doi.org/10.1016/s0006-8993(00)03280-7
https://doi.org/10.1016/s0006-8993(00)03280-7
Publikováno v:
Journal of Neurochemistry. 74:1106-1111
The polyamine system is very sensitive to different pathological states of the brain and is perturbed after CNS injury. The main modifications are significant increases in ornithine decarboxylase activity and an increase in tissue putrescine levels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db2c021f5e207c7297e5c3673dd0ffc
https://doi.org/10.1046/j.1471-4159.2000.741106.x
https://doi.org/10.1046/j.1471-4159.2000.741106.x
Publikováno v:
Journal of Neuroscience Research. 58:697-705
CDP-choline is a rate-limiting intermediate in the biosynthesis of phosphatidylcholine (PtdCho), an important component of the neural cell membrane. The ability of CDP-choline to alter phospholipid metabolism is an important function in the treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9740a788e856f218af6fc0f1e2aab4ee
https://doi.org/10.1002/(sici)1097-4547(19991201)58:5<697::aid-jnr11>3.0.co
https://doi.org/10.1002/(sici)1097-4547(19991201)58:5<697::aid-jnr11>3.0.co
Autor:
Mustafa K. Baskaya, Aclan Dogan, James F. Hatcher, Robert J. Dempsey, V. L. Raghavendra Rao, A. Muralikrishna Rao
Publikováno v:
Journal of Neurochemistry. 72:765-770
The possible effects of the polyamine interconversion pathway on tissue polyamine levels, brain edema formation, and ischemic injury volume were studied by using a selective irreversible inhibitor, MDL 72527, of the interconversion pathway enzyme, po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da4c172594eec434d148cd4887be5c9
https://doi.org/10.1046/j.1471-4159.1999.0720765.x
https://doi.org/10.1046/j.1471-4159.1999.0720765.x
Publikováno v:
Neurochemical Research. 24:1225-1232
Accumulation of arachidonic acid (AA) is greatest in brain regions most sensitive to transient ischemia. Free AA released after ischemia is either: 1) reincorporated into the membrane phospholipids, or 2) oxidized during reperfusion by lipoxygenases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b28ba2d0ed14814c7a29412ca082cf14
https://doi.org/10.1023/a:1020916905312
https://doi.org/10.1023/a:1020916905312
Autor:
A. Muralikrishna Rao, Aclan Doǧan, Mustafa K. Baskaya, Vemuganti L. Raghavendra Rao, Robert J. Dempsey
Publikováno v:
Brain Research. 783:163-166
There is increasing evidence that the elevated levels of polyamines play an important role in the secondary injury following traumatic brain injury (TBI). Ornithine decarboxylase (ODC) is the rate-limiting enzyme of polyamine biosynthesis. Presently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d384e18f8be4b7137a3ecefa36cf1220
https://doi.org/10.1016/s0006-8993(97)01301-2
https://doi.org/10.1016/s0006-8993(97)01301-2
Autor:
A. Muralikrishna Rao, Aclan Doğgan, Mustafa K. Baskaya, V. L. Raghavendra Rao, Jane Rastl, Robert J. Dempsey, David Donaldson
Publikováno v:
Journal of Neurosurgery. 87:921-926
✓ Polyamines and N-methyl-d-aspartate (NMDA) receptors are both thought to play an important role in secondary neuronal injury after cerebral ischemia. Ifenprodil, known as a noncompetitive inhibitor of polyamine sites at the NMDA receptor, was stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce50d44e2f7a8166228457c6161f13f8
https://doi.org/10.3171/jns.1997.87.6.0921
https://doi.org/10.3171/jns.1997.87.6.0921
Publikováno v:
Molecular Brain Research. 44:134-138
We have studied the beneficial effects of S-adenosyl-L-methionine (SAM) tosylate on blood-brain barrier (BBB) breakdown and neuronal survival after transient cerebral ischemia in gerbils. BBB breakdown experiments were performed in pentobarbital anes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d18c41abe05e6c923a27bdff5507b454
https://doi.org/10.1016/s0169-328x(96)00245-8
https://doi.org/10.1016/s0169-328x(96)00245-8
Autor:
Adibhatla Muralikrishna Rao, Robert J. Dempsey, Prasad Mr, David Donaldson, Mustafa K. Baskaya
Publikováno v:
Neurosurgery. 40:364-371
OBJECTIVE Ifenprodil, a polyamine site N-methyl-D-aspartate receptor/channel antagonist, has been reported to decrease infarction volume after cerebral ischemia. However, the possible mechanisms of this protective effect have not been studied in deta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b3c80c64afefbe5dba872503237871
https://doi.org/10.1097/00006123-199702000-00026
https://doi.org/10.1097/00006123-199702000-00026