Zobrazeno 1 - 10
of 51
pro vyhledávání: '"A. Mieke Timmermans"'
Autor:
Marcel Smid, Marjanka K. Schmidt, Wendy J. C. Prager-van der Smissen, Kirsten Ruigrok-Ritstier, Maartje A. C. Schreurs, Sten Cornelissen, Aida Marsal Garcia, Annegien Broeks, A. Mieke Timmermans, Anita M. A. C. Trapman-Jansen, J. Margriet Collée, Muriel A. Adank, Maartje J. Hooning, John W. M. Martens, Antoinette Hollestelle
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-14 (2023)
Abstract Background CHEK2 c.1100delC was the first moderate-risk breast cancer (BC) susceptibility allele discovered. Despite several genomic, transcriptomic and functional studies, however, it is still unclear how exactly CHEK2 c.1100delC promotes t
Externí odkaz:
https://doaj.org/article/8c35660b50404179bb0c665e16566e2a
Autor:
Shuoying Qu, A. Mieke Timmermans, Bernadette A. M. Heemskerk-Gerritsen, Anita M. A. C. Trapman-Jansen, Renée Broeren-Foekens, Wendy J. C. Prager-van der Smissen, Hoesna El Hassnaoui, Tim van Tienhoven, Claudia K. Bes-Stobbe, Pieter J. Westenend, Carolien H. M. van Deurzen, John W. M. Martens, Maartje J. Hooning, Antoinette Hollestelle
Publikováno v:
Cancers, Vol 16, Iss 1, p 28 (2023)
The ferritin-heavy chain (FTH1) is the catalytic subunit of the ferroxidase ferritin, which prevents oxidative DNA damage via intracellular iron storage. FTH1 was shown to be a prognostic marker for triple-negative breast cancer (BC) patients and ass
Externí odkaz:
https://doaj.org/article/429258d99040435092040aea788a11a9
Autor:
Silvia R. Vitale, Kirsten Ruigrok-Ritstier, A. Mieke Timmermans, Renée Foekens, Anita M. A. C. Trapman-Jansen, Corine M. Beaufort, Paolo Vigneri, Stefan Sleijfer, John W. M. Martens, Anieta M. Sieuwerts, Maurice P. H. M. Jansen
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-16 (2022)
Abstract Background In breast cancer (BC), recurrent fusion genes of estrogen receptor alpha (ESR1) and AKAP12, ARMT1 and CCDC170 have been reported. In these gene fusions the ligand binding domain of ESR1 has been replaced by the transactivation dom
Externí odkaz:
https://doaj.org/article/5619f8611366419781ebf77950eb8c5c
Autor:
Anna E. M. Bastiaansen, A. Mieke Timmermans, Marcel Smid, Carolien H. M. van Deurzen, Esther S. P. Hulsenboom, Wendy J. C. Prager-van der Smissen, Renée Foekens, Anita M. A. C. Trapman-Jansen, Peter A. E. Sillevis Smitt, Theo M. Luider, John W. M. Martens, Martijn M. vanDuijn
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract New therapies are an urgent medical need in all breast cancer subgroups. Metabotropic glutamate receptor 1 (mGluR1) is suggested as a potential new molecular target. We examined the prevalence mGluR1 expression in different clinically releva
Externí odkaz:
https://doaj.org/article/857bf571bd7b4be593d8884fd1a9208e
Autor:
Diana Ramirez-Ardila, A. Mieke Timmermans, Jean A. Helmijr, John W.M. Martens, Els M.J.J. Berns, Maurice P.H.M. Jansen
Publikováno v:
Translational Oncology, Vol 10, Iss 5, Pp 854-866 (2017)
INTRODUCTION: While mutations in PIK3CA are most frequently (45%) detected in luminal breast cancer, downstream PI3K/AKT/mTOR pathway activation is predominantly observed in the basal subtype. The aim was to identify proteins activated in PIK3CA muta
Externí odkaz:
https://doaj.org/article/6657e8cf443844d6a34dbdef52a85d3d
Autor:
Roberto A. Leon-Ferre, Sarah Flora Jonas, Roberto Salgado, Sherene Loi, Vincent De Jong, Jodi M. Carter, Torsten Nielson, Samuel Leung, Nazia Riaz, Giuseppe Curigliano, Carmen Criscitiello, Vincent Cockenpot, Matteo Lambertini, Vera Suman, Barbro Linderholm, John WM Martens, Carolien HM van Deurzen, Mieke Timmermans, Tatsunori Shimoi, Shu Yazaki, Masayuki Yoshida, Sung-Bae Kim, Hee Jin Lee, Maria Vittoria Dieci, Guillaume Bataillon, Anne Salomon, Fabrice Andre, Marleen Kok, Sabine Linn, Matthew P. Goetz, Stefan Michiels
Publikováno v:
Cancer Research. 83:PD9-05
Background: The prognostic value of stromal tumor-infiltrating lymphocytes (TILs) as a biomarker for triple-negative breast cancer (TNBC) has been extensively demonstrated in patients (pts) receiving (neo)adjuvant systemic therapy. In addition, sever
Autor:
Maurice P.H.M. Jansen, Paolo Vigneri, Stefan Sleijfer, Corine M. Beaufort, Silvia R. Vitale, John Martens, Anieta M. Sieuwerts, Anita M. A. C. Trapman-Jansen, A. Mieke Timmermans, Kirsten Ruigrok-Ritstier, Renée Foekens
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-16 (2022)
BMC Cancer, 22(1):165. BioMed Central Ltd.
BMC Cancer, 22(1):165. BioMed Central Ltd.
Background In breast cancer (BC), recurrent fusion genes of estrogen receptor alpha (ESR1) and AKAP12, ARMT1 and CCDC170 have been reported. In these gene fusions the ligand binding domain of ESR1 has been replaced by the transactivation domain of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e83b5eb241980e2a29bd5c0b52757a0
http://hdl.handle.net/20.500.11769/524144
http://hdl.handle.net/20.500.11769/524144
Autor:
Hayri E. Balcioglu, Iris Nederlof, Mieke Timmermans, John W.M. Martens, Reno Debets, Renée Foekens, Olga I. Isaeva, Rebecca Wijers, Hugo M. Horlings, Marcel Smid, Anita M. A. C. Trapman-Jansen, Dora Hammerl, Roberto Salgado, Leonie Voorwerk, Marleen Kok
Publikováno v:
Nature Communications, 12(1):5668. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Only a subgroup of triple-negative breast cancer (TNBC) responds to immune checkpoint inhibitors (ICI). To better understand lack of response to ICI, we analyze 681 TNBCs for spatial immune cell contextures in relation to clinical outcomes and pathwa
Autor:
Chayenne J. Heijerman, Marie Colombe Agahozo, Mieke Timmermans, Dora Hammerl, Carolien H.M. van Deurzen, Ronald van Marion, Marcel Smid, Reno Debets, Pieter J. Westenend, Thierry P P van den Bosch, John W.M. Martens
Publikováno v:
Biology
Volume 10
Issue 8
Biology, Vol 10, Iss 768, p 768 (2021)
Biology, 10(8):768. Multidisciplinary Digital Publishing Institute (MDPI)
Volume 10
Issue 8
Biology, Vol 10, Iss 768, p 768 (2021)
Biology, 10(8):768. Multidisciplinary Digital Publishing Institute (MDPI)
Simple Summary Tumor-infiltrating lymphocytes (TILs) are likely to play a role in the biological behavior of HER2+ ductal carcinoma in situ (DCIS). To prevent invasiveness, the potential of targeted immune-modulating treatment of HER2+ DCIS has been
Autor:
Stefan Sleijfer, Paul Hamberg, Marcel Smid, Mieke Timmermans, Wendy Onstenk, John W.M. Martens, Jaco Kraan, Agnes Jager, Felix E. de Jongh, Ingeborg E. de Kruijff, Anieta M. Sieuwerts
Publikováno v:
International Journal of Cancer, 145(4), 1083-1089. Wiley-Liss Inc.
The androgen receptor (AR) has potential clinical relevance in metastatic breast cancer (mBC) since it might be a treatment target and has been associated with endocrine resistance. A minimal-invasive way to determine AR expression on metastatic tumo