Low-dose azathioprine and allopurinol versus azathioprine monotherapy in patients with ulcerative colitis (AAUC): An investigator-initiated, open, multicenter, parallel-arm, randomised controlled trial

Autor: Marianne Kiszka-Kanowitz, Klaus Theede, Sandra Bohn Thomsen, Jacob Tveiten Bjerrum, Jørn Brynskov, Ida Benedikte Gottschalck, Elena Akimenko, Karen Lisa Hilsted, Anders Neumann, Signe Wildt, Lone Larsen, Jens Kristian Munk, Per Holger Ibsen, Huma Gul Rehana Janjua, Lise Lotte Gluud, Anette Mertz-Nielsen

Publikováno v: EClinicalMedicine, Vol 45, Iss , Pp 101332- (2022)

Summary: Background: Retrospective studies suggest that for patients with ulcerative colitis (UC) combination therapy with low-dose azathioprine and allopurinol (L-AZA/ALLO) may result in higher remission rates than monotherapy with azathioprine (AZA

Externí odkaz: https://doaj.org/article/97e99eefbcd243a1995ac82e77994a54

The Use and Efficacy of Biological Therapies for Inflammatory Bowel Disease in a Danish Tertiary Centre 2010-2020

Autor: Mads Damsgaard Wewer, Laura Arp, Melek Sarikaya, Oluf Krautwald Felding, Ida Vind, Gitte Pedersen, Anette Mertz-Nielsen, Marianne Kiszka-Kanowitz, Trine Boysen, Klaus Theede, Andreas Munk Petersen, Inge Nordgaard-Lassen, Flemming Bendtsen, Johan Burisch

Publikováno v: Wewer, M D, Arp, L, Sarikaya, M, Felding, O K, Vind, I, Pedersen, G, Mertz-Nielsen, A, Kiszka-Kanowitz, M, Boysen, T, Theede, K, Petersen, A M, Nordgaard-Lassen, I, Bendtsen, F & Burisch, J 2022, ' The Use and Efficacy of Biological Therapies for Inflammatory Bowel Disease in a Danish Tertiary Centre 2010-2020 ', Crohn's and Colitis 360, vol. 4, no. 4, otac041 . https://doi.org/10.1093/crocol/otac041

Background Patients with inflammatory bowel disease (IBD) who receive biologicals frequently experience lack or loss of response. Our aim was to describe the use and efficacy of biological therapy in a tertiary IBD center. Methods We included all bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79306536821e39118c173c97023eed7
https://curis.ku.dk/ws/files/338171159/otac041.pdf

Outcome of concomitant treatment with thiopurines and allopurinol in patients with inflammatory bowel disease:A nationwide Danish cohort study

Autor: Kristine H. Allin, Johan Burisch, Tine Jess, Klaus Theede, Susanne Hansen, Sandra Bohn Thomsen, Camilla B. Jensen, Lise Lotte Gluud, Marianne Kiszka-Kanowitz, Anette Mertz Nielsen

Publikováno v: Thomsen, S B, Allin, K H, Burisch, J, Jensen, C B, Hansen, S, Gluud, L L, Theede, K, Kiszka-Kanowitz, M, Nielsen, A M & Less, T 2020, ' Outcome of concomitant treatment with thiopurines and allopurinol in patients with inflammatory bowel disease : A nationwide Danish cohort study ', European Journal of Gastroenterology and Hepatology, vol. 8, no. 1, pp. 68-76 . https://doi.org/10.1177/2050640619868387

BACKGROUND: Thiopurine and allopurinol in combination are associated with clinical remission in inflammatory bowel diseases but their influence on subsequent outcomes is unclear. We compared outcomes during exposure to both thiopurines and allopurino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b92c01a5531daae2b275fa57a40bd4
https://curis.ku.dk/portal/da/publications/outcome-of-concomitant-treatment-with-thiopurines-and-allopurinol-in-patients-with-inflammatory-bowel-disease(14d41a13-de3c-449d-8377-10f2f37d8f64).html

The Impact of Endoscopic Inflammation and Mucosal Healing on Health-related Quality of Life in Ulcerative Colitis Patients

Autor: Anette Mertz Nielsen, Klaus Theede, Marianne Kiszka-Kanowitz, Inge Nordgaard-Lassen

Publikováno v: Journal of Crohn's and Colitis. 9:625-632

Background: Health-related quality of life [HRQoL] is impaired in ulcerative colitis and is correlated to clinical disease activity. The recent shift towards more objective treatment goals like mucosal healing generates a need for evaluating the asso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260a9eddb0f4ea2512384a83b0496348
https://doi.org/10.1093/ecco-jcc/jjv081

The correlation between fecal calprotectin, simple clinical colitis activity index and biochemical markers in ulcerative colitis during high-dose steroid treatment

Autor: Klaus Theede, Anette Mertz Nielsen, Inge Nordgaard-Lassen, Marianne Kiszka-Kanowitz

Publikováno v: Scandinavian Journal of Gastroenterology. 49:418-423

Monitoring active ulcerative colitis (UC) is essential for making correct and timely treatment decisions. The current monitoring is based on symptom scores and biochemical markers, among which the role of fecal calprotectin (FC) is debated. The aims

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6412b1bc16df16d33bd4edda600c61d2
https://doi.org/10.3109/00365521.2014.883427