Zobrazeno 1 - 10
of 29
pro vyhledávání: '"A. Mary Thangakani"'
Publikováno v:
Bioinformatics and Biology Insights, Vol 2016, Iss 10, Pp 73-80 (2016)
Externí odkaz:
https://doaj.org/article/986b622cf0f7479488632e09df6b023c
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152949 (2016)
Accurate distinction between peptide sequences that can form amyloid-fibrils or amorphous β-aggregates, identification of potential aggregation prone regions in proteins, and prediction of change in aggregation rate of a protein upon mutation(s) are
Externí odkaz:
https://doaj.org/article/f7829863f42b41f68fe7569985e611f8
Publikováno v:
Biophys Rev
Protein aggregation is a topic of immense interest to the scientific community due to its role in several neurodegenerative diseases/disorders and industrial importance. Several in silico techniques, tools, and algorithms have been developed to predi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf8320306f493f3ba69e7db62f2dedd
https://europepmc.org/articles/PMC7930180/
https://europepmc.org/articles/PMC7930180/
Autor:
M. Michael Gromiha, R. Prabakaran, Ramasamy Sakthivel, A. Mary Thangakani, Sandeep Kumar, Puneet Rawat
Publikováno v:
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 27(2)
The Curated Protein Aggregation Database (CPAD) is a manually curated and open-access database dedicated to providing comprehensive information related to mechanistic, kinetic and structural aspects of protein and peptide aggregation. The database ha
Autor:
Daisuke Kobayashi, Attayeb Mohsen, Masakazu Sekijima, Tomoki Ito, M. Michael Gromiha, Masahiro Mochizuki, Mika Sakamoto, Kenji Mizuguchi, Modong Tan, Hideaki Umeyama, Nobuaki Yasuo, Shuntaro Chiba, Shogo Suzuki, Takashi Ishida, Kazuyoshi Ikeda, Daisuke Kihara, Yoshitaka Moriwaki, Yutaka Akiyama, Reiji Teramoto, A. Mary Thangakani, Shintaro Minami, Vipul Gupta, Mitsuo Iwadate, Chioko Nagao, Takaaki Ichikawa, Kazuki Yamamoto, Masahito Ohue, Itsuo Nakane, Kei Yura, Tatsuya Okuno, George Chikenji, Masahiro Kawatani, Kun Yi Hsin, Sakurako Takashina, Takatsugu Hirokawa, Woong-Hee Shin, Devadasan Velmurugan, Hayase Hakariya, Chandrasekaran Ramakrishnan, Ryunosuke Yoshino, Hironori K. Nakamura, Philip Prathipati, Nobuaki Miura, Hiroaki Kitano, Sergey Zozulya, Mari Ito, Akiko Higuchi, Teruki Honma, Petro Borysko, Keita Oda, Anastasiia Gryniukova, Nanako Uchida, Kentaroh Kudoh
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Potential inhibitors of a target biomolecule, NAD-dependent deacetylase Sirtuin 1, were identified by a contest-based approach, in which participants were asked to propose a prioritized list of 400 compounds from a designated compound library contain
Autor:
Shintaro Minami, Chandrasekaran Ramakrishnan, Petro Borysko, Takashi Ishida, Hideaki Umeyama, M. Michael Gromiha, Shuntaro Chiba, Shogo Suzuki, George Chikenji, Mitsuo Iwadate, A. Mary Thangakani, Masakazu Sekijima, Kazuyoshi Ikeda, Keisuke Yanagisawa, Daisuke Kihara, Y-h. Taguchi, Reiji Teramoto, Sergey Zozulya, Devadasan Velmurugan, Woong-Hee Shin, Tatsuya Okuno, Teruki Honma, Masahiro Mochizuki, Kazuki Yamamoto, Yoshitaka Moriwaki, Takatsugu Hirokawa, Ryunosuke Yoshino, Roman Stavniichuk, Yutaka Akiyama, Nobuaki Yasuo, Koya Kato
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
We propose a new iterative screening contest method to identify target protein inhibitors. After conducting a compound screening contest in 2014, we report results acquired from a contest held in 2015 in this study. Our aims were to identify target e
Publikováno v:
Bioinformatics. 30:1983-1990
Motivation: Distinguishing between amyloid fibril-forming and amorphous β-aggregating aggregation-prone regions (APRs) in proteins and peptides is crucial for designing novel biomaterials and improved aggregation inhibitors for biotechnological and
Autor:
Rawat, Puneet, Prabakaran, R., Sakthivel, R., Mary Thangakani, A., Kumar, Sandeep, Gromiha, M. Michael
Publikováno v:
Amyloid; Jun2020, Vol. 27 Issue 2, p128-133, 6p
The main cause of several neurodegenerative diseases such as Alzhemier, Parkinson and spongiform encephalopathies is formation of amyloid fibrils and plaques in proteins. We have analyzed different sets of proteins and peptides to understand the infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ec3a5e286f94a7683fd2cb05e4a52c
Autor:
R. Nagarajan, Devadasan Velmurugan, M. Michael Gromiha, A. Mary Thangakani, Sandeep Kumar, Satish K. Singh
Publikováno v:
Scientific Reports
Why do patients suffering from neurodegenerative diseases generate autoantibodies that selectively bind soluble aggregates of amyloidogenic proteins? Presently, molecular basis of interactions between the soluble aggregates and human immune system is