Zobrazeno 1 - 1
of 1
pro vyhledávání: '"A. Marianne C. F. Castelijns"'
Novel reductive amination of nitriles: An efficient route to 5-hydroxypiperidone-derived N,N-acetals
Autor:
Mandy K. S. Vink, Antonina Mackova‐Zabelinskaja, Herfried Griengl, Hans E. Schoemaker, Henk Hiemstra, Peter Pöchlauer, Martin H. Fechter, A. Marianne C. F. Castelijns, Floris P. J. T. Rutjes, Christien A. Schortinghuis, Jan H. van Maarseveen
Publikováno v:
Advanced Synthesis & Catalysis, 345(4), 483-487. Wiley-VCH Verlag
5-Hydroxypiperidin-2-one is a versatile building block for the preparation of potentially biologically active compounds. We detail an enantioselective biocatalytic approach towards its synthesis using (S)-hydroxynitrile lyase (HNL)-mediated cyanohydr