Zobrazeno 1 - 10
of 20
pro vyhledávání: '"A. M. van den Berk"'
Autor:
Aldo Spanjaard, Maria Stratigopoulou, Daniël de Groot, Muhammad Aslam, Paul C. M. van den Berk, Chantal Stappenbelt, Matilda Ayidah, Joyce J. I. Catsman, Iris N. Pardieck, Maaike Kreft, Ramon Arens, Jeroen E. J. Guikema, Heinz Jacobs
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
The development and differentiation of B cells is intimately linked to cell proliferation and the generation of diverse immunoglobulin gene (Ig) repertoires. The ubiquitin E3 ligase HUWE1 controls proliferation, DNA damage responses, and DNA repair,
Externí odkaz:
https://doaj.org/article/1d18cf86772b41ecb3b2e4147ddbb1f9
Autor:
Luiza S. E. P. Will Castro, Wietske Pieters, Mir Farshid Alemdehy, Muhammad A. Aslam, Olimpia Alessandra Buoninfante, Jonne A. Raaijmakers, Bas Pilzecker, Paul C. M. van den Berk, Hein te Riele, René H. Medema, Rozangela C. Pedrosa, Heinz Jacobs
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The antihelmintic drug ABZ and its metabolites belong to the chemical family of benzimidazoles (BZM) that act as potent tubulin polymerization inhibitors, suggesting a potential re-direction of BZMs for cancer therapy. Applying UV-Vis spectrometry we
Externí odkaz:
https://doaj.org/article/9e76e3ae24f2402f8606460ae34df061
Autor:
Jacobs, Ronak Shah, Paul C. M. van den Berk, Colin E. J. Pritchard, Ji-Ying Song, Maaike Kreft, Bas Pilzecker, Heinz
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 11129
Fanconi anemia (FA) develops due to a mutation in one of the FANC genes that are involved in the repair of interstrand crosslinks (ICLs). FANCG, a member of the FA core complex, is essential for ICL repair. Previous FANCG-deficient mouse models were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::f26556eb6bf6c1748909af95c85c2d4d
Autor:
Aldo Spanjaard, Ronak Shah, Daniël de Groot, Olimpia Alessandra Buoninfante, Ben Morris, Cor Lieftink, Colin Pritchard, Lisa M Zürcher, Shirley Ormel, Joyce J I Catsman, Renske de Korte-Grimmerink, Bjørn Siteur, Natalie Proost, Terry Boadum, Marieke van de Ven, Ji-Ying Song, Maaike Kreft, Paul C M van den Berk, Roderick L Beijersbergen, Heinz Jacobs
Publikováno v:
Nucleic Acids Research. 50:7420-7435
Crosslink repair depends on the Fanconi anemia pathway and translesion synthesis polymerases that replicate over unhooked crosslinks. Translesion synthesis is regulated via ubiquitination of PCNA, and independently via translesion synthesis polymeras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d9c57af872ef1699819a71b23deb58
https://doi.org/10.1093/nar/gkac545
https://doi.org/10.1093/nar/gkac545
Autor:
Olimpia Alessandra Buoninfante, Bas Pilzecker, Aldo Spanjaard, Daniël de Groot, Stefan Prekovic, Ji-Ying Song, Cor Lieftink, Matilda Ayidah, Colin E. J. Pritchard, Judith Vivié, Kathleen E. Mcgrath, Ivo J. Huijbers, Sjaak Philipsen, Marieke von Lindern, Wilbert Zwart, Roderick L. Beijersbergen, James Palis, Paul C. M. van den Berk, Heinz Jacobs
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 120(4):e2216055120. National Academy of Sciences
DNA damage threatens genomic integrity and instigates stem cell failure. To bypass genotoxic lesions during replication, cells employ DNA damage tolerance (DDT), which is regulated via PCNA ubiquitination and REV1. DDT is conserved in all domains of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1e077fb0f8ba8a59c4009b6aa84c1c
https://pure.eur.nl/en/publications/97d9e55e-3739-4a7c-9feb-61f4e8e1c6a8
https://pure.eur.nl/en/publications/97d9e55e-3739-4a7c-9feb-61f4e8e1c6a8
Autor:
Asbjørn M. Scholtens, Jan Paul Esser, N. L. van der Sluis, Hein J. Verberne, G. K. Lammers, A. M. van den Berk, Marnix G.E.H. Lam, J. M. H. De Klerk
Publikováno v:
European journal of nuclear medicine and molecular imaging, 47(11), 2698-2702. Springer Verlag
Introduction: Adequate suppression of physiologic myocardial glucose uptake is important to ensure the interpretability and diagnostic reliability of [18F]fluorodeoxyglucose (FDG) PET/CT studies performed in the context of cardiac inflammation and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3877b12e01080f2e6a7de568dcb7af86
https://doi.org/10.1007/s00259-020-04713-1
https://doi.org/10.1007/s00259-020-04713-1
Autor:
Marc A Hogenbirk, Marinus R Heideman, Arno Velds, Paul C M van den Berk, Ron M Kerkhoven, Bas van Steensel, Heinz Jacobs
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69815 (2013)
The Aicda locus encodes the activation induced cytidine deaminase (AID) and is highly expressed in germinal center (GC) B cells to initiate somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes. Besides these I
Externí odkaz:
https://doaj.org/article/4f3946697d894dee97a6365ed48f3ee5
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16669 (2011)
Monoubiquitylation of the homotrimeric DNA sliding clamp PCNA at lysine residue 164 (PCNA(K164)) is a highly conserved, DNA damage-inducible process that is mediated by the E2/E3 complex Rad6/Rad18. This ubiquitylation event recruits translesion synt
Externí odkaz:
https://doaj.org/article/3c5f9de1d9ff406ea01c6051fdb4296c
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15236 (2010)
To generate high affinity antibodies during an immune response, B cells undergo somatic hypermutation (SHM) of their immunoglobulin genes. Error-prone translesion synthesis (TLS) DNA polymerases have been reported to be responsible for all mutations
Externí odkaz:
https://doaj.org/article/d2e77dad11a5417ab2ff7bdcb316ff15
Autor:
Inne H.M. Borel Rinkes, Wessel M.C.M. Vorselaars, Wouter P. Kluijfhout, Thijs van Dalen, Bart de Keizer, John M. H. de Klerk, Gerlof D. Valk, Sandra A M van den Berk, Menno R. Vriens
Publikováno v:
Nuclear Medicine Communications, 37(12), 1246. Lippincott Williams and Wilkins
BACKGROUND: Several reports have shown good performance of fluorine-18 fluorocholine (F-FCH) PET-computed tomography (CT) for parathyroid localization, although overall evidence remains scarce. We collected data from three institutions in the Netherl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d1574701df12efe5046f97bc1808be
https://pubmed.ncbi.nlm.nih.gov/27612033
https://pubmed.ncbi.nlm.nih.gov/27612033