Zobrazeno 1 - 3
of 3
pro vyhledávání: '"A. M. Strizhevskaya"'
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 48-53 (2020)
In children oncology high doses of methotrexate (HD Mtx) use for treatment of osteosarcoma, acute lymphoblastic leukemia and many others tumors. Due to high intra- and interindividual Mtx pharmacokinetic variability it is essential perform monitoring
Externí odkaz:
https://doaj.org/article/456d745a65a149bcad6817afc6e985c8
Publikováno v:
Успехи молекулярной онкологии, Vol 2, Iss 1, Pp 082-089 (2015)
Methotrexate (Mtx) is a cytotoxic drug from the group of antimetabolites, folic acid antagonists. High-dose (HD) Mtx in pediatric oncology are used for the treatment of osteosarcoma (OS), and other types of tumors. This therapy has allowed to achieve
Externí odkaz:
https://doaj.org/article/8fab9aa7a80b4812b1fef5b9c115a7f7
Publikováno v:
Patologicheskaia fiziologiia i eksperimental'naia terapiia. (2)
High-dose methotrexate blocks the metabolic pathways of conversion of homocysteine to methionine. As a result, homocysteine (hcy) accumulates in the blood. The aim of this study was to determine the relationship between changes in concentrations of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b18ee107970be7f9c3b8ebd90ff6f643
https://pubmed.ncbi.nlm.nih.gov/25318162
https://pubmed.ncbi.nlm.nih.gov/25318162