Zobrazeno 1 - 10
of 250
pro vyhledávání: '"A. M. Stearns"'
Autor:
Kristen M. Stearns-Reider, Michael R. Hicks, Katherine G. Hammond, Joseph C. Reynolds, Alok Maity, Yerbol Z. Kurmangaliyev, Jesse Chin, Adam Z. Stieg, Nicholas A. Geisse, Sophia Hohlbauch, Stefan Kaemmer, Lauren R. Schmitt, Thanh T. Pham, Ken Yamauchi, Bennett G. Novitch, Roy Wollman, Kirk C. Hansen, April D. Pyle, Rachelle H. Crosbie
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-22 (2023)
Abstract We developed an on-slide decellularization approach to generate acellular extracellular matrix (ECM) myoscaffolds that can be repopulated with various cell types to interrogate cell-ECM interactions. Using this platform, we investigated whet
Externí odkaz:
https://doaj.org/article/c2a5068dfc864da18363d4d91d1aaa4b
Autor:
Jackie L. McCourt, Kristen M. Stearns-Reider, Hafsa Mamsa, Pranav Kannan, Mohammad Hossein Afsharinia, Cynthia Shu, Elizabeth M. Gibbs, Kara M. Shin, Yerbol Z. Kurmangaliyev, Lauren R. Schmitt, Kirk C. Hansen, Rachelle H. Crosbie
Publikováno v:
Skeletal Muscle, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Background The dystrophin-glycoprotein complex (DGC) is a critical adhesion complex of the muscle cell membrane, providing a mechanical link between the extracellular matrix (ECM) and the cortical cytoskeleton that stabilizes the sarcolemma
Externí odkaz:
https://doaj.org/article/b2cf4b0572df49f7aea7868e8825730a
Autor:
Ramani Soundararajan, Helena Hernández-Cuervo, Timothy M Stearns, Anthony J Griswold, Sahebgowda Sidramagowda Patil, Jutaro Fukumoto, Venkata Ramireddy Narala, Lakshmi Galam, Richard Lockey, Narasaiah Kolliputi
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: Critically ill patients on supplemental oxygen therapy eventually develop acute lung injury (ALI). Reactive oxygen species (ROS) produced during ALI perturbs the mitochondrial dynamics resulting in cellular damage. Genetic deletion of the
Externí odkaz:
https://doaj.org/article/60d6092c74c549c8962d337265289e32
Autor:
Harriet M. Jackson, Kate E. Foley, Rita O’Rourke, Timothy M. Stearns, Dina Fathalla, B. Paul Morgan, Gareth R. Howell
Publikováno v:
BMC Genetics, Vol 21, Iss 1, Pp 1-16 (2020)
Abstract Background The complement cascade is increasingly implicated in development of a variety of diseases with strong immune contributions such as Alzheimer’s disease and Systemic Lupus Erythematosus. Mouse models have been used to determine fu
Externí odkaz:
https://doaj.org/article/614e55b302c34685b237b64274f950f7
Autor:
Emma Westermann-Clark, Ramani Soundararajan, Jutaro Fukumoto, Sahebgowda Sidramagowda Patil, Timothy M. Stearns, Smita Saji, Alexander Czachor, Helena Hernandez-Cuervo, Mason Breitzig, Sudarshan Krishnamurthy, Richard F. Lockey, Narasaiah Kolliputi
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 283 (2022)
Abnormalities in airway epithelia and lung parenchyma are found in Atp8b1 mutant mice, which develop pulmonary fibrosis after hyperoxic insult. Microarray and ingenuity pathway analysis (IPA) show numerous transcripts involved in ciliogenesis are dow
Externí odkaz:
https://doaj.org/article/c543cc6e09624b9d88bffc5c6421d434
Publikováno v:
PeerJ, Vol 7, p e6586 (2019)
In this study, we investigated the impact of initial tumor volume, rate of tumor growth, cohort size, study duration, and data analysis method on chemotherapy treatment response classifications in patient-derived xenografts (PDXs). The analyses were
Externí odkaz:
https://doaj.org/article/48caf2190af14f229f3b7d6f4a29e13d
Autor:
Jennifer J. Trowbridge, Grant A. Challen, Timothy M. Stearns, Logan S. Schwartz, Kristina D. Mujica, Jayna J. Mistry, Kira A. Young, Matthew A. Loberg, Elizabeth Eudy, Jennifer M. SanMiguel
Clonal hematopoiesis resulting from the enhanced fitness of mutant hematopoietic stem cells (HSC) associates with both favorable and unfavorable health outcomes related to the types of mature mutant blood cells produced, but how this lineage output i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7f7a21e96cf495b84841121be73722
https://doi.org/10.1158/2159-8290.c.6549771.v1
https://doi.org/10.1158/2159-8290.c.6549771.v1
Autor:
Jennifer J. Trowbridge, Grant A. Challen, Timothy M. Stearns, Logan S. Schwartz, Kristina D. Mujica, Jayna J. Mistry, Kira A. Young, Matthew A. Loberg, Elizabeth Eudy, Jennifer M. SanMiguel
Supplementary Table from Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d31af7a1d42a11622f5574145b29ff
https://doi.org/10.1158/2159-8290.22541943
https://doi.org/10.1158/2159-8290.22541943
Autor:
Jennifer J. Trowbridge, Grant A. Challen, Timothy M. Stearns, Logan S. Schwartz, Kristina D. Mujica, Jayna J. Mistry, Kira A. Young, Matthew A. Loberg, Elizabeth Eudy, Jennifer M. SanMiguel
Supplementary Figure from Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e5687f5dde5659afc0844c64ba40dc
https://doi.org/10.1158/2159-8290.22541946
https://doi.org/10.1158/2159-8290.22541946
Autor:
Kyuson Yun, Jeong K. Yoon, Susan L. Ackerman, Roderick T. Bronson, Timothy M. Stearns, Michael D. Taylor, David J. Shih, Emily E. Miller, Yaochen Li, Sivaraman Natarajan
PDF file - 65K, Supplementary Figure 6. A schematic drawing of full length N1ICD in mouse, N1ICD allele analyzed in this study, and the ACTB-Notch1 allele previously published (Yang et al., 2004) and analyzed in Supplementary Figure 6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d19da1cb4ea06fda60fd764a78e719
https://doi.org/10.1158/0008-5472.22398012.v1
https://doi.org/10.1158/0008-5472.22398012.v1