Zobrazeno 1 - 10
of 408
pro vyhledávání: '"A. M. Schilder"'
Autor:
Dana M. Chase, Soham Shukla, Julia Moore, Tirza Areli Calderón Boyle, Jonathan Lim, Jessica Perhanidis, Jean A. Hurteau, Jeanne M. Schilder
Publikováno v:
Oncology and Therapy, Vol 12, Iss 3, Pp 599-607 (2024)
Abstract Introduction Niraparib first-line maintenance (1LM) therapy has demonstrated clinical benefit for patients with ovarian cancer (OC) in clinical trial and real-world settings, but data on factors associated with real-world patient outcomes re
Externí odkaz:
https://doaj.org/article/877785eaaff34eb1860b79fe8e83b988
Autor:
Bobbie Rimel, Tirza Areli Calderón Boyle, Sara Burns, Jonathan Lim, John Hartman, Linda Kalilani, Jeanne M. Schilder, Jean A. Hurteau, Amanda Golembesky
Publikováno v:
Oncology and Therapy, Vol 12, Iss 3, Pp 465-475 (2024)
Abstract Introduction Clinical trials have demonstrated prolonged survival associated with niraparib first-line maintenance (1LM) therapy, compared with placebo, for patients with ovarian cancer (OC). However, data are limited on real-world 1LM nirap
Externí odkaz:
https://doaj.org/article/be7e5d732cdc4346b5c2c634f5e5b807
Autor:
Anne G. M. Schilder, Stephan Wolpert, Shakeel Saeed, Leonie M. Middelink, Albert S. B. Edge, Helen Blackshaw, REGAIN Consortium, Kostas Pastiadis, Athanasios G. Bibas
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Inhibition of Notch signalling with a gamma-secretase inhibitor (GSI) induces mammalian hair cell regeneration and partial hearing restoration. In this proof-of-concept Phase I/IIa multiple-ascending dose open-label trial (ISRCTN59733689), a
Externí odkaz:
https://doaj.org/article/c507482871e1458b9e7192e6aabb92b2
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Despite calls to improve reproducibility in research, achieving this goal remains elusive even within computational fields. Currently, >50% of R packages are distributed exclusively through GitHub. While the trend towards sharing open-source
Externí odkaz:
https://doaj.org/article/a11a3cccc3cb411ab4f7c0f7d3122975
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/5239697fe8a94ac890ce1200c210b805
Autor:
Avgi Loizidou, Taranjit Singh Tatla, Ian Harvey, Miriayi Aibibula, Justin Roe, Neeraj Sethi, Anne G. M. Schilder
Publikováno v:
BMC Health Services Research, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Flexible nasendoscopy (FNE) is an invaluable multi-disciplinary tool for upper aerodigestive tract (UADT) examination. During the COVID-19 pandemic concerns were raised that FNE had the potential of generating aerosols resulting i
Externí odkaz:
https://doaj.org/article/3a254b19d42f4f0492ad389ceb91b704
Autor:
Paul Little, Alastair D Hay, Lucy Yardley, G Ardine de Wit, Nicolaas P A Zuithoff, Sibyl Anthierens, Roderick P Venekamp, Anne G M Schilder, Roger A M J Damoiseaux, Elisabeth A M Sanders, Saskia Hullegie, Joline L H de Sévaux
Publikováno v:
BMJ Open, Vol 13, Iss 2 (2023)
Introduction Ear pain is the most prominent symptom of childhood acute otitis media (AOM). To control the pain and reduce reliance on antibiotics, evidence of effectiveness for alternative interventions is urgently needed. This trial aims to investig
Externí odkaz:
https://doaj.org/article/c4f15a0209f245c88647c4e00575252f
Autor:
Rick T. van Uum, Roderick P. Venekamp, Clémence T. B. Pasmans, G. Ardine de Wit, Alies Sjoukes, Alma C. van der Pol, Roger A. M. J. Damoiseaux, Anne G. M. Schilder
Publikováno v:
BMC Health Services Research, Vol 21, Iss 1, Pp 1-9 (2021)
Abstract Background Acute otitis media (AOM) is among the most common paediatric conditions managed in primary care. Most recent estimates of the cost of AOM date from a decade ago and lack a full societal perspective. We therefore explored the socie
Externí odkaz:
https://doaj.org/article/98a2c72ae3124236b10ebbfa87e9ed4a
Autor:
Evie C. Landry, Mirre Scholte, Matthew P. Su, Yvette Horstink, Rishi Mandavia, Maroeska M. Rovers, Anne G. M. Schilder
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
BackgroundHealth systems face challenges to accelerate access to innovations that add value and avoid those unlikely to do so. This is very timely to the field of age-related sensorineural hearing loss (ARHL), where a significant unmet market need ha
Externí odkaz:
https://doaj.org/article/857753b07afc40039c02316eb20670f4
Publikováno v:
Neurobiology of Disease, Vol 163, Iss , Pp 105580- (2022)
Genome-Wide Association Studies (GWAS) have elucidated the genetic components of Parkinson's Disease (PD). However, because the vast majority of GWAS association signals fall within non-coding regions, translating these results into an interpretable,
Externí odkaz:
https://doaj.org/article/2b877f6768904191a1ed53ac502c4213