The JaCVAM international validation study on the in vivo comet assay: Selection of test chemicals

Autor: Takeshi Morita, Leonard M. Schechtman, Hajime Kojima, Raffaella Corvi, Yoshifumi Uno, Masamitsu Honma, Makoto Hayashi, Raymond R. Tice

Publikováno v: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. :14-44

The Japanese Center for the Validation of Alternative Methods (JaCVAM) sponsored an international prevalidation and validation study of the in vivo rat alkaline pH comet assay. The main objective of the study was to assess the sensitivity and specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19fd0d251d5d9494ded586b2827d87fb
https://doi.org/10.1016/j.mrgentox.2015.03.004

Cell transformation assays for prediction of carcinogenic potential: state of the science and future research needs

Autor: Kamala Pant, James Harvey, Albrecht Poth, Andrew D. Scott, Stuart Creton, Kiyoshi Sasaki, Rhine R. Shen, Marilyn J. Aardema, Noriho Tanaka, Robert F. Newbold, Francis Martin, Paul L. Carmichael, Ayako Sakai, Hemad Yasaei, Leonard M. Schechtman, Michael R. O’Donovan

Publikováno v: Mutagenesis

Copyright @ 2011 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d31c0682d25178ea32c935c521f32ec
https://doi.org/10.1093/mutage/ger053

JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for detection of genotoxic carcinogens: II. Summary of definitive validation study results

Autor: Yoshifumi Uno, Hajime Kojima, Takashi Omori, Raffaella Corvi, Masamistu Honma, Leonard M. Schechtman, Raymond R. Tice, Carol Beevers, Marlies De Boeck, Brian Burlinson, Cheryl A. Hobbs, Sachiko Kitamoto, Andrew R. Kraynak, James McNamee, Yuzuki Nakagawa, Kamala Pant, Ulla Plappert-Helbig, Catherine Priestley, Hironao Takasawa, Kunio Wada, Uta Wirnitzer, Norihide Asano, Patricia A. Escobar, David Lovell, Takeshi Morita, Madoka Nakajima, Yasuo Ohno, Makoto Hayashi

Publikováno v: Mutation research. Genetic toxicology and environmental mutagenesis.

The in vivo rodent alkaline comet assay (comet assay) is used internationally to investigate the in vivo genotoxic potential of test chemicals. This assay, however, has not previously been formally validated. The Japanese Center for the Validation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51aa1acac2989944c6af4f1e0c5112b2
https://pubmed.ncbi.nlm.nih.gov/26212295

Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use

Autor: Diana Rembges, David H. Blakey, Daniela Maurici, Susanna-Assunta Sansone, Hans Jürgen Ahr, Leonard M. Schechtman, Ian Indans, George Orphanides, Tohru Inoue, John P. Groten, Raffaella Corvi, Joost H.M. van Delft, Bernd Haase, Sylvio Albertini, Eisaku Toda, Karen Hamernik, Weida Tong, Libero Clerici, Brenda K. Weis, Thomas Hartung, George R. Douglas, Sandra Coecke, Laura Gribaldo, Jason Snape

Publikováno v: Environmental Health Perspectives
Environmental Health Perspectives, 114(3), 420-429. U.S. Department of Health and Human Services; National Institute of Environmental Health Sciences

This is the report of the first workshop "Validation of Toxicogenomics-Based Test Systems" held 11-12 December 2003 in Ispra, Italy. The workshop was hosted by the European Centre for the Validation of Alternative Methods (ECVAM) and organized jointl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c503291bd3a181bdb25cc4b1e662be6d
https://doi.org/10.1289/ehp.8247

Implementation of the 3Rs (Refinement, Reduction, and Replacement): Validation and Regulatory Acceptance Considerations for Alternative Toxicological Test Methods

Autor: Leonard M. Schechtman

Publikováno v: ILAR Journal. 43:S85-S94

Toxicological testing in the current regulatory environment is steeped in a history of using animals to answer questions about the safety of products to which humans are exposed. That history forms the basis for the testing strategies that have evolv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8457cf3399c777ed652fb6895d8ab42
https://doi.org/10.1093/ilar.43.suppl_1.s85