Zobrazeno 1 - 10
of 134
pro vyhledávání: '"A. M. Randi"'
Autor:
C. Peghaire, N. P. Dufton, M. Lang, I. I. Salles-Crawley, J. Ahnström, V. Kalna, C. Raimondi, C. Pericleous, L. Inuabasi, R. Kiseleva, V. R. Muzykantov, J. C. Mason, G. M. Birdsey, A. M. Randi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
The endothelium actively maintains an anticoagulant surface through expression of thrombomodulin. Here, Peghaire et al. identify an anti-thrombotic pathway that controls thrombomodulin expression selectively in regions of low shear stress, via cooper
Externí odkaz:
https://doaj.org/article/7798914f5f094e87a7d8b776f5a7230c
Autor:
A. V. Shah, G. M. Birdsey, C. Peghaire, M. E. Pitulescu, N. P. Dufton, Y. Yang, I. Weinberg, L. Osuna Almagro, L. Payne, J. C. Mason, H. Gerhardt, R. H. Adams, A. M. Randi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Vascular maturation and stability is regulated by Notch and Angiopoietin-1/Tie2 signalling. Here, Shahet al. show that the transcription factor ERG coordinates the Ang1, Notch and Wnt/β-catenin pathways to promote vascular maturation and stability.
Externí odkaz:
https://doaj.org/article/5f4b6819b7ab45719c0100c6dc529987
Autor:
Marie B. Lang, Kit-Yi Leung, Nicholas D.E. Greene, Kerri M. Malone, Gaye Saginc, Anna M. Randi, Allan Kiprianos, Robert T. Maughan, Charis Pericleous, Justin C. Mason
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
ObjectivesThe disease-modifying anti-rheumatic drug methotrexate (MTX) is recognized to reduce cardiovascular risk in patients with systemic inflammatory diseases. However, the molecular basis for these cardioprotective effects remains incompletely u
Externí odkaz:
https://doaj.org/article/5d363a763a9c431a9c93d4a8e3417ea0
Autor:
Theo Issitt, Emy Bosseboeuf, Natasha De Winter, Neil Dufton, Gaia Gestri, Valentina Senatore, Anissa Chikh, Anna M. Randi, Claudio Raimondi
Publikováno v:
iScience, Vol 11, Iss , Pp 205-223 (2019)
Summary: The transmembrane protein neuropilin-1 (NRP1) promotes vascular endothelial growth factor (VEGF) and extracellular matrix signaling in endothelial cells (ECs). Although it is established that NRP1 is essential for angiogenesis, little is kno
Externí odkaz:
https://doaj.org/article/3d93fbcc84b445d396a8543ea382f882
Autor:
Robert F. Sidonio, Jr, Paulette C. Bryant, Jorge Di Paola, Sarah Hale, Meadow Heiman, G Shellye Horowitz, Christi Humphrey, Julie Jaffray, Lora C. Joyner, Raj Kasthuri, Barbara A. Konkle, Peter A. Kouides, Robert Montgomery, Keith Neeves, Anna M. Randi, Nikole Scappe, Cristina Tarango, Kelly Tickle, Pamela Trapane, Michael Wang, Brittany Waters, Veronica H. Flood
Publikováno v:
Expert Review of Hematology. 16:39-54
BACKGROUND: Excessive or abnormal mucocutaneous bleeding (MCB) may impact all aspects of the physical and psychosocial wellbeing of those who live with it (PWMCB). The evidence base for the optimal diagnosis and management of disorders such as inheri
Autor:
null Ilham Albohari, null Eka Swajaya Putri, null Mawar Puspita sari, null M. Randi Briliansaputra, null Tomi Hidayat
Publikováno v:
Setawar Abdimas. 2:22-27
Kelurahan Malabero merupakan salah satu sentral masyarakat nelayan penghasil makanan laut (seafood) di Kota Bengkulu. Mata pencaharian nelayan Kelurahan Malabero berpotensi cukup besar dimana pada musim panen rata-rata setiap nelayan mampu memproduks
Autor:
Rakshin Kharwadkar, Benjamin J. Ulrich, Michelle Chu, Byunghee Koh, Matthew M. Hufford, Yongyao Fu, Graeme M. Birdsey, Bo T. Porse, Anna M. Randi, Mark H. Kaplan
Publikováno v:
The Journal of Immunology. 210:537-546
CD4+ TH cells develop into subsets that are specialized in the secretion of particular cytokines to mediate restricted types of inflammation and immune responses. Among the subsets that promote development of allergic inflammatory responses, IL-9–p
Autor:
Jesus M. Gomez-Salinero, Tomer Itkin, Sean Houghton, Chaitanya Badwe, Yang Lin, Viktoria Kalna, Neil Dufton, Claire R. Peghaire, Masataka Yokoyama, Matthew Wingo, Tyler M. Lu, Ge Li, Jenny Zhaoying Xiang, Yen-Michael Sheng Hsu, David Redmond, Ryan Schreiner, Graeme M. Birdsey, Anna M. Randi, Shahin Rafii
Publikováno v:
Nat Cardiovasc Res
Current dogma dictates that, during adulthood, endothelial cells (ECs) are locked in an immutable stable homeostatic state. By contrast, herein we show that maintenance of EC fate and function are linked and active processes, which depend on the cons
Autor:
Emy Bosseboeuf, Anissa Chikh, Ahmed Bey Chaker, Tom P. Mitchell, Dhilakshani Vignaraja, Ridhi Rajendrakumar, Rayomand S. Khambata, Thomas D. Nightingale, Justin C. Mason, Anna M. Randi, Amrita Ahluwalia, Claudio Raimondi
Publikováno v:
Science Signaling. 16
Linear and disturbed flow differentially regulate gene expression, with disturbed flow priming endothelial cells (ECs) for a proinflammatory, atheroprone expression profile and phenotype. Here, we investigated the role of the transmembrane protein ne
Autor:
Golzar Mobayen, Koval Smith, Kushani Ediriwickrema, Richard D. Starke, Emmanouil Georgios Solomonidis, Michael A. Laffan, Anna M. Randi, Thomas A.J. McKinnon
BACKGROUND: The von Willebrand factor (VWF) is a multimeric plasma glycoprotein essential for hemostasis, inflammation, and angiogenesis. The majority of VWF is synthesized by endothelial cells (ECs) and stored in Weibel-Palade bodies (WPB). Among th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2b73f70472e4f24171978e34607f3a
http://hdl.handle.net/10044/1/104704
http://hdl.handle.net/10044/1/104704