Zobrazeno 1 - 10
of 368
pro vyhledávání: '"A. M. Parkhurst"'
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114215- (2024)
Summary: Cells have robust wound repair systems to prevent further damage or infection and to quickly restore cell cortex integrity when exposed to mechanical and chemical stress. Actomyosin ring formation and contraction at the wound edge are major
Externí odkaz:
https://doaj.org/article/79a0c2285ace4c078dd267fff0298745
Autor:
James M. Parkhurst, Adam D. Crawshaw, C. Alistair Siebert, Maud Dumoux, C. David Owen, Pedro Nunes, David Waterman, Thomas Glen, David I. Stuart, James H. Naismith, Gwyndaf Evans
Publikováno v:
IUCrJ, Vol 10, Iss 3, Pp 270-287 (2023)
Three-dimensional electron diffraction (3DED) from nanocrystals of biological macromolecules requires the use of very small crystals. These are typically less than 300 nm-thick in the direction of the electron beam due to the strong interaction betwe
Externí odkaz:
https://doaj.org/article/e0f2750b21824a2da2eac4a6e181c76f
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Rho family GTPases regulate both linear and branched actin dynamics by activating downstream effectors to facilitate the assembly and function of complex cellular structures such as lamellipodia and contractile actomyosin rings. Wiskott-Aldr
Externí odkaz:
https://doaj.org/article/46f00131308f422fba93dfad3db10dfa
Publikováno v:
Cells, Vol 12, Iss 11, p 1532 (2023)
In the original publication [...]
Externí odkaz:
https://doaj.org/article/93f23d5d6abc4495830c7928fbca07c1
Autor:
Anthony O. Beas, Patricia B. Gordon, Clara L. Prentiss, Carissa Perez Olsen, Matthew A. Kukurugya, Bryson D. Bennett, Susan M. Parkhurst, Daniel E. Gottschling
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Age-associated metabolic changes include lipid accumulation. Here, the authors show that with replicative aging yeast accumulate lipid droplets which protect cells from cold stress and can be modulated through Biosynthesis of NAD+ 2 (BNA2).
Externí odkaz:
https://doaj.org/article/ccc42411f0664158949caf4ea685050d
Autor:
Melanie Vollmar, James M. Parkhurst, Dominic Jaques, Arnaud Baslé, Garib N. Murshudov, David G. Waterman, Gwyndaf Evans
Publikováno v:
IUCrJ, Vol 7, Iss 2, Pp 342-354 (2020)
This study describes a method to estimate the likelihood of success in determining a macromolecular structure by X-ray crystallography and experimental single-wavelength anomalous dispersion (SAD) or multiple-wavelength anomalous dispersion (MAD) pha
Externí odkaz:
https://doaj.org/article/ddfba1d3f2eb453ca6f10a0722b1cf77
Autor:
James M. Parkhurst, Maud Dumoux, Mark Basham, Daniel Clare, C. Alistair Siebert, Trond Varslot, Angus Kirkland, James H. Naismith, Gwyndaf Evans
Publikováno v:
Open Biology, Vol 11, Iss 10 (2021)
In cryo-electron tomography (cryo-ET) of biological samples, the quality of tomographic reconstructions can vary depending on the transmission electron microscope (TEM) instrument and data acquisition parameters. In this paper, we present Parakeet, a
Externí odkaz:
https://doaj.org/article/70cf5223a322452fb78cf19561387825
Publikováno v:
Cells, Vol 11, Iss 18, p 2777 (2022)
To cope with continuous physiological and environmental stresses, cells of all sizes require an effective wound repair process to seal breaches to their cortex. Once a wound is recognized, the cell must rapidly plug the injury site, reorganize the cy
Externí odkaz:
https://doaj.org/article/4e285a509a1c4b60b8259652addf05c6
Autor:
Mitsutoshi Nakamura, Jeffrey M Verboon, Tessa E Allen, Maria Teresa Abreu-Blanco, Raymond Liu, Andrew N M Dominguez, Jeffrey J Delrow, Susan M Parkhurst
Publikováno v:
PLoS Genetics, Vol 16, Iss 12, p e1009186 (2020)
Cells are exposed to frequent mechanical and/or chemical stressors that can compromise the integrity of the plasma membrane and underlying cortical cytoskeleton. The molecular mechanisms driving the immediate repair response launched to restore the c
Externí odkaz:
https://doaj.org/article/2c807706b195430a899ca85a63cc725d
Autor:
Emma V. Beale, David G. Waterman, Corey Hecksel, Jason van Rooyen, James B. Gilchrist, James M. Parkhurst, Felix de Haas, Bart Buijsse, Gwyndaf Evans, Peijun Zhang
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
MicroED has recently emerged as a powerful method for the analysis of biological structures at atomic resolution. This technique has been largely limited to protein nanocrystals which grow either as needles or plates measuring only a few hundred nano
Externí odkaz:
https://doaj.org/article/a360773de2214620ac65ecc967425cdd