Zobrazeno 1 - 10
of 45
pro vyhledávání: '"A. M. P. Wright"'
Publikováno v:
Pharmacological Research, Vol 209, Iss , Pp 107443- (2024)
Microglia, the resident immune cells of the brain, regulate the balance of inflammation in the central nervous system under healthy and pathogenic conditions. Huntington’s disease (HD) is a chronic neurodegenerative disease characterized by activat
Externí odkaz:
https://doaj.org/article/717cec1a887c42f793148a1f632fbbc9
Publikováno v:
Geophysical Research Letters, Vol 51, Iss 12, Pp n/a-n/a (2024)
Abstract Seasonal hindcasts have previously been demonstrated to show multi‐decadal variability in skill across the twentieth century in indices describing El‐Niño Southern Oscillation (ENSO), which drives global seasonal predictability. Here, w
Externí odkaz:
https://doaj.org/article/eb144fa2d7eb413fa8ebcff89d4c997f
Publikováno v:
Cancer Medicine, Vol 12, Iss 15, Pp 16173-16180 (2023)
Abstract Purpose The objective of this study is to determine primary survival endpoints in women with recurrent and metastatic endometrial carcinoma (RMEC) treated with progestins. Methods A retrospective chart review was conducted at The Ottawa Hosp
Externí odkaz:
https://doaj.org/article/c2fc397b9ad94141a8bd77d28ffd1217
Autor:
Glenwood D. Goss, Johanna N. Spaans, David Huntsman, Timothy Asmis, Natalie M. Andrews Wright, Marc Duciaume, Pardeep Kaurah, Ruth R. Miller, Shantanu Banerji, Harmanjatinder S. Sekhon, Marcio M. Gomes
Publikováno v:
Current Oncology, Vol 29, Iss 5, Pp 3171-3186 (2022)
Inuit are the Indigenous Arctic peoples and residents of the Canadian territory of Nunavut who have the highest global rate of lung cancer. Given lung cancer’s mortality, histological and genomic characterization was undertaken to better understand
Externí odkaz:
https://doaj.org/article/19fa4df936c2416ab987aef3528518a4
Autor:
Amina M. Bagher, Alexander P. Young, Thikryat Neamatallah, Reham M. Al-Amoudi, Sara M. Bagher, Eileen M. Denovan-Wright
Publikováno v:
Annals of Saudi Medicine, Vol 41, Iss 1, Pp 1-7 (2021)
BACKGROUND: Methylenetetrahydrofolate reductase, the encoded by the MTHFR gene, plays a crucial role in converting the amino acid homocysteine to methionine. Two polymorphisms of the MTHFR gene, C677T and A1298C, reportedly reduce enzyme activity, re
Externí odkaz:
https://doaj.org/article/15a74407a01c4ec4b6c109c5517d2430
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Microglia, the resident immune cells of the brain, can take on a range of pro- or anti-inflammatory phenotypes to maintain homeostasis. However, the sustained activation of pro-inflammatory microglia can lead to a state of chronic neuroinflammation c
Externí odkaz:
https://doaj.org/article/1113add7e60b4fbaaacb051bd70a4b67
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Preterm infants are at high risk of death and disability resulting from brain injury. Impaired cardiovascular function leading to poor cerebral oxygenation is a significant contributor to these adverse outcomes, but current therapeutic approaches hav
Externí odkaz:
https://doaj.org/article/fdfa2cb6d54a4bada3c40648ed6d4157
Autor:
D. K. Syahbana, K. Kasbani, G. Suantika, O. Prambada, A. S. Andreas, U. B. Saing, S. L. Kunrat, S. Andreastuti, M. Martanto, E. Kriswati, Y. Suparman, H. Humaida, S. Ogburn, P. J. Kelly, J. Wellik, H. M. N. Wright, J. D. Pesicek, R. Wessels, C. Kern, M. Lisowski, A. Diefenbach, M. Poland, F. Beauducel, J. Pallister, R. G. Vaughan, J. B. Lowenstern
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Abstract After 53 years of quiescence, Mount Agung awoke in August 2017, with intense seismicity, measurable ground deformation, and thermal anomalies in the summit crater. Although the seismic unrest peaked in late September and early October, the v
Externí odkaz:
https://doaj.org/article/4aaf6d9b86de47aabc180a33238d21f3
Publikováno v:
Health & Justice, Vol 6, Iss 1, Pp 1-13 (2018)
Abstract Background Prisoners are at increased risk of self-harm and when either intent is expressed, or an act of self-harm carried out, prisoners in the UK are subject to self-harm/suicide monitoring (referred to as “open ACCT” monitoring). How
Externí odkaz:
https://doaj.org/article/1c70271ce26b42a99b3387d3a4e6ca15
Autor:
Robert B. Laprairie, Kawthar A. Mohamed, Ayat Zagzoog, Melanie E. M. Kelly, Lesley A. Stevenson, Roger Pertwee, Eileen M. Denovan-Wright, Ganesh A. Thakur
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
In addition to its known actions as a non-selective cyclooxygenase (COX) 1 and 2 inhibitor, we hypothesized that indomethacin can act as an allosteric modulator of the type 1 cannabinoid receptor (CB1R) because of its shared structural features with
Externí odkaz:
https://doaj.org/article/0af22acc2b2c405fb3735e48f6927486