Germline specific genes increase DNA double-strand break repair and radioresistance in lung adenocarcinoma cells

Autor: Wenqing Liu, Jan Willem Bruggeman, Qijing Lei, Ans M. M. van Pelt, Jan Koster, Geert Hamer

Publikováno v: Cell Death and Disease, Vol 15, Iss 1, Pp 1-11 (2024)

Abstract In principle, germline cells possess the capability to transmit a nearly unaltered set of genetic material to infinite future generations, whereas somatic cells are limited by strict growth constraints necessary to assure an organism’s phy

Externí odkaz: https://doaj.org/article/fee5ef7725da4c08941c4e5827747a30

Sperm DNA methylation is predominantly stable in mice offspring born after transplantation of long-term cultured spermatogonial stem cells

Autor: Joana B. Serrano, Nils C. Tabeling, Cindy M. de Winter-Korver, Saskia K. M. van Daalen, Ans M. M. van Pelt, Callista L. Mulder

Publikováno v: Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)

Abstract Background Spermatogonial stem cell transplantation (SSCT) is proposed as a fertility therapy for childhood cancer survivors. SSCT starts with cryopreserving a testicular biopsy prior to gonadotoxic treatments such as cancer treatments. When

Externí odkaz: https://doaj.org/article/1abbe68efe0342e8bab574dc8981b903

Meiotic Chromosome Synapsis and XY-Body Formation In Vitro

Autor: Qijing Lei, Eden Zhang, Ans M. M. van Pelt, Geert Hamer

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

To achieve spermatogenesis in vitro, one of the most challenging processes to mimic is meiosis. Meiotic problems, like incomplete synapsis of the homologous chromosomes, or impaired homologous recombination, can cause failure of crossover formation a

Externí odkaz: https://doaj.org/article/b7168626032f45b9b5f88317d32ee424

Transcriptional comparison of testicular adrenal rest tumors with fetal and adult tissues

Autor: Mariska A M Schröder, Fred C G J Sweep, Antonius E van Herwaarden, Rod T Mitchell, Jitske Eliveld, Ans M M van Pelt, Alan E Rowan, Darren Korbie, Nike M M L Stikkelbroeck, Hedi L Claahsen-van der Grinten, Paul N Span

Publikováno v: European Journal of Endocrinology, 187, 607-615
European Journal of Endocrinology, 187(5), 607-615. BioScientifica Ltd.
European Journal of Endocrinology, 187, 5, pp. 607-615
Schröder, M A M, Sweep, F C G J, Van Herwaarden, A E, Mitchell, R T, Eliveld, J, Van Pelt, A M M, Rowan, A E, Korbie, D, Stikkelbroeck, N M M L, Claahsen-van Der Grinten, H L & Span, P N 2022, ' Transcriptional comparison of Testicular Adrenal Rest Tumors with fetal and adult tissues ', European Journal of Endocrinology . https://doi.org/10.1530/EJE-22-0143

Background Testicular adrenal rest tumors (TART) are a common complication of unknown cellular origin in patients with congenital adrenal hyperplasia (CAH). These benign tumors have both adrenal and testicular characteristics and are hypothesized to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eed266099adce8e3ac6ac84af3639b6
https://doi.org/10.1530/eje-22-0143

Childhood cancer and hematological disorders negatively affect spermatogonial quantity at diagnosis : a retrospective study of a male fertility preservation cohort

Autor: Ieva Masliukaite, Elissavet Ntemou, Elizabeth A M Feijen, Marianne van de Wetering, Andreas Meissner, Alexandre T Soufan, Sjoerd Repping, Leontien M C Kremer, Kirsi Jahnukainen, Ellen Goossens, Ans M M van Pelt

Publikováno v: Human reproduction (Oxford, England), 38(3), 359-370. Oxford University Press
Masliukaite, I, Ntemou, E, Feijen, E A M, van de Wetering, M, Meissner, A, Soufan, A T, Repping, S, Kremer, L M C, Jahnukainen, K, Goossens, E & van Pelt, A M M 2023, ' Childhood cancer and hematological disorders negatively affect spermatogonial quantity at diagnosis : a retrospective study of a male fertility preservation cohort ', Human reproduction (Oxford, England), vol. 38, no. 3, pp. 359-370 . https://doi.org/10.1093/humrep/dead004

STUDY QUESTIONWhat is the impact of cancer or hematological disorders on germ cells in pediatric male patients?SUMMARY ANSWERSpermatogonial quantity is reduced in testes of prepubertal boys diagnosed with cancer or severe hematological disorder compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb8670db0d7a2441c926d09fbb131df
http://hdl.handle.net/10138/355944