Zobrazeno 1 - 10
of 234
pro vyhledávání: '"A. M. L. Lever"'
Publikováno v:
Cell Transplantation, Vol 15 (2006)
Neural transplantation of human fetal tissue for Huntington's disease (HD) is now entering the clinical arena. The safety of the procedure has now been demonstrated in a number of studies, although the efficacy of such an approach is still being inve
Externí odkaz:
https://doaj.org/article/af51b35d6a3c4a848df1e95dd41b6132
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Recognition of similarities between chronic fatigue syndrome and idiopathic intracranial hypertension (IIH) has raised suggestions that they might be connected, with chronic fatigue syndrome representing a mild version of IIH, sharing many of its sym
Externí odkaz:
https://doaj.org/article/313805416e2d4474ae5aa6080f056c31
Autor:
Aaron R. D’Souza, Dhivya Jayaraman, Ziqi Long, Jingwei Zeng, Liam J. Prestwood, Charlene Chan, Dennis Kappei, Andrew M. L. Lever, Julia C. Kenyon
Publikováno v:
Viruses, Vol 13, Iss 12, p 2389 (2021)
HIV-1 packages two copies of its gRNA into virions via an interaction with the viral structural protein Gag. Both copies and their native RNA structure are essential for virion infectivity. The precise stepwise nature of the packaging process has not
Externí odkaz:
https://doaj.org/article/f334a79e6870445aa2d9c87e59dd058b
Publikováno v:
Viruses, Vol 13, Iss 11, p 2130 (2021)
Our understanding of RNA structure has lagged behind that of proteins and most other biological polymers, largely because of its ability to adopt multiple, and often very different, functional conformations within a single molecule. Flexibility and m
Externí odkaz:
https://doaj.org/article/719a716a176d44d1b2984ae369a4b33b
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 9, p e1007345 (2019)
HIV-1 replicates via a low-fidelity polymerase with a high mutation rate; strong conservation of individual nucleotides is highly indicative of the presence of critical structural or functional properties. Identifying such conservation can reveal nov
Externí odkaz:
https://doaj.org/article/cb918929c4994360be6f5aab14ef4a11
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Transcriptionally silent HIV proviruses form the major obstacle to eradicating HIV. Many studies of HIV latency have focused on the cellular mechanisms that maintain silencing of proviral DNA. Here we show that viral sequence variation affec
Externí odkaz:
https://doaj.org/article/5ec59ece3af14869b31e20e379fa66bf
Autor:
Bo Meng, Andrew M. L. Lever
Publikováno v:
Viruses, Vol 13, Iss 2, p 324 (2021)
Viruses are obligate parasites that rely on host cellular factors to replicate and spread. The endosomal sorting complexes required for transport (ESCRT) system, which is classically associated with sorting and downgrading surface proteins, is one of
Externí odkaz:
https://doaj.org/article/c48dd2a460c644dfbcd69edb3ecf31f1
Publikováno v:
Nucleic Acids Research
Clinical usage of lentiviral vectors is now established and increasing but remains constrained by vector titer with RNA packaging being a limiting factor. Lentiviral vector RNA is packaged through specific recognition of the packaging signal on the R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3fe067d2cc2cf29277d01d0edd9a1c
https://doi.org/10.1093/nar/gkab1206
https://doi.org/10.1093/nar/gkab1206
Autor:
Julia C. Kenyon, Katharina M. Scherer, Pedro P. Vallejo Ramirez, Ezra Bruggeman, Andrew M. L. Lever, Clemens F. Kaminski, Bo Meng
Publikováno v:
Traffic. 22:439-453
A number of viruses including HIV use the ESCRT system to bud from the infected cell. We have previously confirmed biochemically that ESCRT-II is involved in this process in HIV-1 and have defined the molecular domains that are important for this. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25b0f33dd18b6b59b626bbf048e53ce
https://doi.org/10.1111/tra.12820
https://doi.org/10.1111/tra.12820
Development of a Novel Competitive qRT-PCR Assay to Measure Relative Lentiviral Packaging Efficiency
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss, Pp 307-319 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Third-generation HIV-1-derived lentiviral vectors are successfully used as therapeutic agents in various clinical applications. To further promote their use, we attempted to enhance vector infectivity by targeting the dimerization and packaging prope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c8060d947df235329de9845d471543
https://doi.org/10.1016/j.omtm.2020.09.010
https://doi.org/10.1016/j.omtm.2020.09.010