Zobrazeno 1 - 10
of 102
pro vyhledávání: '"A. M. Krackhardt"'
Autor:
Franziska Füchsl, Johannes Untch, Vladyslav Kavaka, Gabriela Zuleger, Sarah Braun, Antonia Schwanzer, Sebastian Jarosch, Carolin Vogelsang, Niklas de Andrade Krätzig, Dario Gosmann, Rupert Öllinger, Piero Giansanti, Michael Hiltensperger, Roland Rad, Dirk H. Busch, Eduardo Beltrán, Eva Bräunlein, Angela M. Krackhardt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Neoantigen-specific T cell receptors (neoTCRs) promise safe, personalized anti-tumor immunotherapy. However, detailed assessment of neoTCR-characteristics affecting therapeutic efficacy is mostly missing. Previously, we identified diverse ne
Externí odkaz:
https://doaj.org/article/b189cc310abe440ea2f4a4bbdc77773d
Autor:
Celina Tretter, Niklas de Andrade Krätzig, Matteo Pecoraro, Sebastian Lange, Philipp Seifert, Clara von Frankenberg, Johannes Untch, Gabriela Zuleger, Mathias Wilhelm, Daniel P. Zolg, Florian S. Dreyer, Eva Bräunlein, Thomas Engleitner, Sebastian Uhrig, Melanie Boxberg, Katja Steiger, Julia Slotta-Huspenina, Sebastian Ochsenreither, Nikolas von Bubnoff, Sebastian Bauer, Melanie Boerries, Philipp J. Jost, Kristina Schenck, Iska Dresing, Florian Bassermann, Helmut Friess, Daniel Reim, Konrad Grützmann, Katrin Pfütze, Barbara Klink, Evelin Schröck, Bernhard Haller, Bernhard Kuster, Matthias Mann, Wilko Weichert, Stefan Fröhling, Roland Rad, Michael Hiltensperger, Angela M. Krackhardt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Systemic pan-tumor analyses may reveal the significance of common features implicated in cancer immunogenicity and patient survival. Here, we provide a comprehensive multi-omics data set for 32 patients across 25 tumor types for proteogenomi
Externí odkaz:
https://doaj.org/article/1b677a5e3e974d68b06b73bc60798d1c
Autor:
Kai Rejeski, Doris K. Hansen, Radhika Bansal, Pierre Sesques, Sikander Ailawadhi, Jennifer M. Logue, Eva Bräunlein, David M. Cordas dos Santos, Ciara L. Freeman, Melissa Alsina, Sebastian Theurich, Yucai Wang, Angela M. Krackhardt, Frederick L. Locke, Emmanuel Bachy, Michael D. Jain, Yi Lin, Marion Subklewe
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-13 (2023)
Abstract Background BCMA-directed CAR T-cell therapy (CAR-T) has altered the treatment landscape of relapsed/refractory (r/r) multiple myeloma, but is hampered by unique side effects that can lengthen hospital stays and increase morbidity. Hematologi
Externí odkaz:
https://doaj.org/article/781664a000bf43b0842a034c8f0fd087
Autor:
Celina Tretter, Niklas de Andrade Krätzig, Matteo Pecoraro, Sebastian Lange, Philipp Seifert, Clara von Frankenberg, Johannes Untch, Gabriela Zuleger, Mathias Wilhelm, Daniel P. Zolg, Florian S. Dreyer, Eva Bräunlein, Thomas Engleitner, Sebastian Uhrig, Melanie Boxberg, Katja Steiger, Julia Slotta-Huspenina, Sebastian Ochsenreither, Nikolas von Bubnoff, Sebastian Bauer, Melanie Boerries, Philipp J. Jost, Kristina Schenck, Iska Dresing, Florian Bassermann, Helmut Friess, Daniel Reim, Konrad Grützmann, Katrin Pfütze, Barbara Klink, Evelin Schröck, Bernhard Haller, Bernhard Kuster, Matthias Mann, Wilko Weichert, Stefan Fröhling, Roland Rad, Michael Hiltensperger, Angela M. Krackhardt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/6cae0f5158ae4314ac4ec8b239aa4306
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Adoptive cell therapy (ACT) has seen a steep rise of new therapeutic approaches in its immune-oncology pipeline over the last years. This is in great part due to the recent approvals of chimeric antigen receptor (CAR)-T cell therapies and their remar
Externí odkaz:
https://doaj.org/article/a26d1c6b0efb4953bd9fa3cc5f8b07dc
Autor:
Dario Gosmann, Lisa Russelli, Wolfgang A. Weber, Markus Schwaiger, Angela M. Krackhardt, Calogero D’Alessandria
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract In the last decades, our understanding of the role of the immune system in cancer has significantly improved and led to the discovery of new immunotherapeutic targets and tools, which boosted the advances in cancer immunotherapy to fight a g
Externí odkaz:
https://doaj.org/article/3285a559d6624a8da1a04ae4c0aef521
Autor:
Mathias Wilhelm, Daniel P. Zolg, Michael Graber, Siegfried Gessulat, Tobias Schmidt, Karsten Schnatbaum, Celina Schwencke-Westphal, Philipp Seifert, Niklas de Andrade Krätzig, Johannes Zerweck, Tobias Knaute, Eva Bräunlein, Patroklos Samaras, Ludwig Lautenbacher, Susan Klaeger, Holger Wenschuh, Roland Rad, Bernard Delanghe, Andreas Huhmer, Steven A. Carr, Karl R. Clauser, Angela M. Krackhardt, Ulf Reimer, Bernhard Kuster
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The identification of HLA peptides by mass spectrometry is non-trivial. Here, the authors extended and used the wealth of data from the ProteomeTools project to improve the prediction of non-tryptic peptides using deep learning, and show their approa
Externí odkaz:
https://doaj.org/article/1610571c49f445ee8754bc881b81762b
Autor:
Melanie Boxberg, Katja Steiger, Wilko Weichert, Roland Rad, Kai Yu, Sebastian Lange, Thomas Engleitner, Huan Lan, Eva Bräunlein, Gaia Lupoli, Franziska Füchsl, Esam T Abualrous, Niklas de Andrade Krätzig, Dario Gosmann, Lukas Wietbrock, Stefan Audehm, Manuel Effenberger, Yinshui Chang, Cigdem Atay, Florian Bassermann, Dirk H Busch, Christian Freund, Iris Antes, Angela M Krackhardt
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 9 (2021)
Externí odkaz:
https://doaj.org/article/1b3e7f5e07ff4e049642ff6e60339d61
Autor:
Franziska Füchsl, Angela M. Krackhardt
Publikováno v:
Cells, Vol 11, Iss 3, p 410 (2022)
Despite the substantial improvement of therapeutic approaches, multiple myeloma (MM) remains mostly incurable. However, immunotherapeutic and especially T cell-based approaches pioneered the therapeutic landscape for relapsed and refractory disease r
Externí odkaz:
https://doaj.org/article/109b889578fc463194bb685dc4939324
Autor:
Stefan Audehm, Manuel Glaser, Matteo Pecoraro, Eva Bräunlein, Sabine Mall, Richard Klar, Manuel Effenberger, Julian Albers, Henrique de Oliveira Bianchi, Janet Peper, Nahid Yusufi, Dirk H. Busch, Stefan Stevanović, Matthias Mann, Iris Antes, Angela M. Krackhardt
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Adoptive transfer of T cells transgenic for tumor-reactive T-cell receptors (TCR) is an attractive immunotherapeutic approach. However, clinical translation is so far limited due to challenges in the identification of suitable target antigens as well
Externí odkaz:
https://doaj.org/article/22a2a126e49249719ac2dc109a786b0d