Zobrazeno 1 - 10
of 362
pro vyhledávání: '"A. M. JAMES SHAPIRO"'
Autor:
Alessandro Parente, MD, PhD, Kevin Verhoeff, MD, PhD, Tatsuya Kin, MD, PhD, Joshua Hefler, MD, PhD, Braulio A. Marfil-Garza, MD, PhD, Norberto Sanchez-Fernandez, MD, Anna Lam, MD, MSc, James Lyon, MD, PhD, Doug O’Gorman, BSc, Khaled Z. Dajani, MD, Blaire L. Anderson, MD, David L. Bigam, MD, MSc, Patrick E. MacDonald, MD, PhD, A. M. James Shapiro, MD, PhD, FRCS (Eng), FRCSC, MSM
Publikováno v:
Transplantation Direct, Vol 10, Iss 7, p e1667 (2024)
Background. Limited information is available regarding outcomes of islet cell isolation (ICI) and transplantation (ITx) using medical assistance in dying (MAiD) donors. We aimed to assess the feasibility and outcomes of ICI and ITx in MAiD donors. Me
Externí odkaz:
https://doaj.org/article/71afa965af904b5c8fc2cf5045e23fbe
Autor:
Nerea Cuesta-Gomez, Kevin Verhoeff, Nidheesh Dadheech, Tiffany Dang, Ila Tewari Jasra, Mario Bermudez de Leon, Rena Pawlick, Braulio Marfil-Garza, Perveen Anwar, Haide Razavy, Patricio Adrián Zapata-Morin, Glen Jickling, Aducio Thiesen, Doug O’Gorman, Michael S. Kallos, A. M. James Shapiro
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Background Induced pluripotent stem cells (iPSCs) offer potential to revolutionize regenerative medicine as a renewable source for islets, dopaminergic neurons, retinal cells, and cardiomyocytes. However, translation of these regenerative ce
Externí odkaz:
https://doaj.org/article/871ddb8a83944edb9407894503394516
Autor:
Ila Tewari Jasra, Nerea Cuesta-Gomez, Kevin Verhoeff, Braulio A. Marfil-Garza, Nidheesh Dadheech, A. M. James Shapiro
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Mitochondria are the powerhouse of the cell and dynamically control fundamental biological processes including cell reprogramming, pluripotency, and lineage specification. Although remarkable progress in induced pluripotent stem cell (iPSC)-derived c
Externí odkaz:
https://doaj.org/article/b2e9252fe80a4403ba987809445a0117
Autor:
Alexander U. Ernst, Long-Hai Wang, Scott C. Worland, Braulio A. Marfil-Garza, Xi Wang, Wanjun Liu, Alan Chiu, Tatsuya Kin, Doug O’Gorman, Scott Steinschneider, Ashim K. Datta, Klearchos K. Papas, A. M. James Shapiro, Minglin Ma
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Transplanting encapsulated insulin-producing cells may achieve a functional cure for type 1 diabetes, but efficacy is constrained by mass transfer limits. Here, the authors report a dynamic computational platform to investigate the therapeutic potenc
Externí odkaz:
https://doaj.org/article/1a9adbcc80c7442e8935f64bbb94e3f8
Publikováno v:
Cells, Vol 12, Iss 20, p 2423 (2023)
Type 1 Diabetes (T1D) is an autoimmune destruction of pancreatic beta cells. The development of the Edmonton Protocol for islet transplantation in 2000 revolutionized T1D treatment and offered a glimpse at a cure for the disease. In 2022, the 20-year
Externí odkaz:
https://doaj.org/article/245deda7422d4ca2875ced66c9ebb538
Autor:
Francesca D’Addio, Anna Maestroni, Emma Assi, Moufida Ben Nasr, Giovanni Amabile, Vera Usuelli, Cristian Loretelli, Federico Bertuzzi, Barbara Antonioli, Francesco Cardarelli, Basset El Essawy, Anna Solini, Ivan C. Gerling, Cristina Bianchi, Gabriella Becchi, Serena Mazzucchelli, Domenico Corradi, Gian Paolo Fadini, Diego Foschi, James F. Markmann, Emanuela Orsi, Jan Škrha, Maria Gabriella Camboni, Reza Abdi, A. M. James Shapiro, Franco Folli, Johnny Ludvigsson, Stefano Del Prato, Gianvincenzo Zuccotti, Paolo Fiorina
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
In this new study the Authors demonstrated that the IGFBP3/TMEM219 pathway is a physiological regulator of pancreatic beta cell homeostasis and it is dysregulated in diabetes. IGFBP3/TMEM219 targeting may therefore serve as a therapeutic option in di
Externí odkaz:
https://doaj.org/article/691fd79ad7294c7890d97254a673270c
Autor:
Joshua Hefler, Braulio A. Marfil-Garza, Rena L. Pawlick, Darren H. Freed, Constantine J. Karvellas, David L. Bigam, A. M. James Shapiro
Publikováno v:
PeerJ, Vol 9, p e12579 (2021)
Acute liver failure is marked by the rapid deterioration of liver function in a previously well patient over period of days to weeks. Though relatively rare, it is associated with high morbidity and mortality. This makes it a challenging disease to s
Externí odkaz:
https://doaj.org/article/e85735c87bd54f628821d613e43ad20d
Perioperative Outcomes Following Kidney-Pancreas Transplantation in Alberta, Canada: Research Letter
Autor:
Danielle E. Fox, Robert R. Quinn, Paul E. Ronksley, Tyrone G. Harrison, Hude Quan, David Bigam, A. M. James Shapiro, Rachel Jeong, Ngan N. Lam
Publikováno v:
Canadian Journal of Kidney Health and Disease, Vol 8 (2021)
Background: Simultaneous kidney-pancreas transplantation (SPK) has benefits for patients with kidney failure and type I diabetes mellitus, but is associated with greater perioperative risk compared with kidney-alone transplantation. Postoperative car
Externí odkaz:
https://doaj.org/article/83fa66472aa64e879773216986c16208
Autor:
Hirofumi Noguchi, Chika Miyagi-Shiohira, Yoshiki Nakashima, Takao Kinjo, Naoya Kobayashi, Issei Saitoh, Masami Watanabe, A. M. James Shapiro, Tatsuya Kin
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 243-252 (2019)
We recently demonstrated the generation of mouse induced tissue-specific stem (iTS) cells through transient overexpression of reprogramming factors combined with tissue-specific selection. Here we induced expandable tissue-specific progenitor (iTP) c
Externí odkaz:
https://doaj.org/article/5767112959d040c5ae59cd02073c1b98
Autor:
Joshua Moss, Judith Magenheim, Daniel Neiman, Hai Zemmour, Netanel Loyfer, Amit Korach, Yaacov Samet, Myriam Maoz, Henrik Druid, Peter Arner, Keng-Yeh Fu, Endre Kiss, Kirsty L. Spalding, Giora Landesberg, Aviad Zick, Albert Grinshpun, A. M. James Shapiro, Markus Grompe, Avigail Dreazan Wittenberg, Benjamin Glaser, Ruth Shemer, Tommy Kaplan, Yuval Dor
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The methylation status of circulating cell-free DNA (cfDNA) can be informative about recent cell death events. Here the authors present an approach to determine the tissue origins of cfDNA, using a reference methylation atlas of 25 human tissues and
Externí odkaz:
https://doaj.org/article/841a0167145749b69b07423fda860202