Zobrazeno 1 - 10
of 138
pro vyhledávání: '"A. M. J. Wensing"'
Autor:
N. V. E. J. Buchholtz, M. M. Nühn, T. C. M. de Jong, T. A. T. Stienstra, K. Reddy, T. Ndung’u, Z. M. Ndhlovu, K. Fisher, S. Palmer, A. M. J. Wensing, J. Symons, M. Nijhuis
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-11 (2024)
Abstract Introduction HIV reservoir quantification is essential for evaluation of HIV curative strategies and may provide valuable insights about reservoir dynamics during antiretroviral therapy. The Intact Proviral DNA Assay (IPDA) provides the uniq
Externí odkaz:
https://doaj.org/article/fd508a47187644d9a48c0217930de817
Autor:
Seth C Inzaule, Mark J Siedner, Susan J Little, Santiago Avila-Rios, Alisen Ayitewala, Ronald J Bosch, Vincent Calvez, Francesca Ceccherini-Silberstein, Charlotte Charpentier, Diane Descamps, Susan H Eshleman, Joseph Fokam, Lisa M Frenkel, Ravindra K Gupta, John P A Ioannidis, Pontiano Kaleebu, Rami Kantor, Seble G Kassaye, Sergei L Kosakovsky Pond, Vinie Kouamou, Roger D Kouyos, Daniel R Kuritzkes, Richard Lessells, Anne-Genevieve Marcelin, Lawrence Mbuagbaw, Brian Minalga, Nicaise Ndembi, Richard A Neher, Roger Paredes, Deenan Pillay, Elliot G Raizes, Soo-Yon Rhee, Douglas D Richman, Kiat Ruxrungtham, Pardis C Sabeti, Jonathan M Schapiro, Sunee Sirivichayakul, Kim Steegen, Wataru Sugiura, Gert U van Zyl, Anne-Mieke Vandamme, Annemarie M J Wensing, Joel O Wertheim, Huldrych F Gunthard, Michael R Jordan, Robert W Shafer
Publikováno v:
PLoS Medicine, Vol 20, Iss 9, p e1004293 (2023)
• Human immunodeficiency virus (HIV) drug resistance has implications for antiretroviral treatment strategies and for containing the HIV pandemic because the development of HIV drug resistance leads to the requirement for antiretroviral drugs that
Externí odkaz:
https://doaj.org/article/c16a34440b374c53938659e86b679144
Autor:
Lidewij W. Rümke, Wouter L. Smit, Ailko Bossink, Gijs J. M. Limonard, Danya Muilwijk, Lenneke E. M. Haas, Chantal Reusken, Sanne van der Wal, Bing J. Thio, Yvonne M. G. van Os, Hendrik Gremmels, Jeffrey M. Beekman, Monique Nijhuis, Annemarie M. J. Wensing, Michiel Heron, Steven F. T. Thijsen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Cellular immune responses are of pivotal importance to understand SARS-CoV-2 pathogenicity. Using an enzyme-linked immunosorbent spot (ELISpot) interferon-γ release assay with wild-type spike, membrane and nucleocapsid peptide pools, we longitudinal
Externí odkaz:
https://doaj.org/article/8c593a6ee121461abf9012f213790a7e
Autor:
Laura E. P. Huyveneers, Anke Bruns, Arjen Stam, Pauline Ellerbroek, Dorien de Jong, Noémi A. Nagy, Stephanie B. H. Gumbs, Kiki Tesselaar, Kobus Bosman, Maria Salgado, Gero Hütter, Lodewijk A. A. Brosens, Mi Kwon, Jose Diez Martin, Jan T. M. van der Meer, Theun M. de Kort, Asier Sáez-Cirión, Julian Schulze zur Wiesch, Jaap Jan Boelens, Javier Martinez-Picado, Jürgen H. E. Kuball, Annemarie M. J. Wensing, Monique Nijhuis
Publikováno v:
Viruses, Vol 14, Iss 9, p 2069 (2022)
Allo-HSCT with CCR5Δ32/Δ32 donor cells is the only curative HIV-1 intervention. We investigated the impact of allo-HSCT on the viral reservoir in PBMCs and post-mortem tissue in two patients. IciS-05 and IciS-11 both received a CCR5Δ32/Δ32 allo-H
Externí odkaz:
https://doaj.org/article/74048228660746cb9b24381e4063dacd
Autor:
Laura E. P. Huyveneers, Mathapelo Maphanga, Chijioke N. Umunnakwe, Larissa Bosman‐de Boer, Robert S. Moraba, Hugo A. Tempelman, Annemarie M. J. Wensing, Lucas E. Hermans
Publikováno v:
Tropical Medicine & International Health. 28:335-342
Autor:
Björn-Erik Ole Jensen, Elena Knops, Leon Cords, Nadine Lübke, Maria Salgado, Kathleen Busman-Sahay, Jacob D. Estes, Laura E. P. Huyveneers, Federico Perdomo-Celis, Melanie Wittner, Cristina Gálvez, Christiane Mummert, Caroline Passaes, Johanna M. Eberhard, Carsten Münk, Ilona Hauber, Joachim Hauber, Eva Heger, Jozefien De Clercq, Linos Vandekerckhove, Silke Bergmann, Gábor A. Dunay, Florian Klein, Dieter Häussinger, Johannes C. Fischer, Kathrin Nachtkamp, Joerg Timm, Rolf Kaiser, Thomas Harrer, Tom Luedde, Monique Nijhuis, Asier Sáez-Cirión, Julian Schulze zur Wiesch, Annemarie M. J. Wensing, Javier Martinez-Picado, Guido Kobbe
Publikováno v:
Nature Medicine. 29:583-587
Despite scientific evidence originating from two patients published to date that CCR5Δ32/Δ32 hematopoietic stem cell transplantation (HSCT) can cure human immunodeficiency virus type 1 (HIV-1), the knowledge of immunological and virological correla
Autor:
Stephanie B. H. Gumbs, Amber Berdenis van Berlekom, Raphael Kübler, Pauline J. Schipper, Lavina Gharu, Marco P. Boks, Paul R. Ormel, Annemarie M. J. Wensing, Lot D. de Witte, Monique Nijhuis
Publikováno v:
Viruses, Vol 14, Iss 4, p 829 (2022)
The achievement of an HIV cure is dependent on the eradication or permanent silencing of HIV-latent viral reservoirs, including the understudied central nervous system (CNS) reservoir. This requires a deep understanding of the molecular mechanisms of
Externí odkaz:
https://doaj.org/article/2321f20662244c68ae92d104af4ad726
Autor:
Lucas E Hermans, Sergio Carmona, Monique Nijhuis, Hugo A Tempelman, Douglas D Richman, Michelle Moorhouse, Diederick E Grobbee, Willem D F Venter, Annemarie M J Wensing
Publikováno v:
PLoS Medicine, Vol 17, Iss 2, p e1003037 (2020)
BACKGROUND:Uptake of antiretroviral treatment (ART) is expanding rapidly in low- and middle-income countries (LMIC). Monitoring of virological suppression is recommended at 6 months of treatment and annually thereafter. In case of confirmed virologic
Externí odkaz:
https://doaj.org/article/0347ed473be24d5a97a6cb20c7b4718e
Autor:
Luna Colagrossi, Lucas E. Hermans, Romina Salpini, Domenico Di Carlo, Suzan D. Pas, Marta Alvarez, Ziv Ben-Ari, Greet Boland, Bianca Bruzzone, Nicola Coppola, Carole Seguin-Devaux, Tomasz Dyda, Federico Garcia, Rolf Kaiser, Sukran Köse, Henrik Krarup, Ivana Lazarevic, Maja M. Lunar, Sarah Maylin, Valeria Micheli, Orna Mor, Simona Paraschiv, Dimitros Paraskevis, Mario Poljak, Elisabeth Puchhammer-Stöckl, François Simon, Maja Stanojevic, Kathrine Stene-Johansen, Nijaz Tihic, Pascale Trimoulet, Jens Verheyen, Adriana Vince, Snjezana Zidovec Lepej, Nina Weis, Tülay Yalcinkaya, Charles A. B. Boucher, Annemarie M. J. Wensing, Carlo F. Perno, Valentina Svicher, on behalf of the HEPVIR working group of the European Society for translational antiviral research (ESAR)
Publikováno v:
BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-12 (2018)
Abstract Background HBsAg immune-escape mutations can favor HBV-transmission also in vaccinated individuals, promote immunosuppression-driven HBV-reactivation, and increase fitness of drug-resistant strains. Stop-codons can enhance HBV oncogenic-prop
Externí odkaz:
https://doaj.org/article/162243061cbc414bb1ca08196034caa5
Autor:
Axel Fun, Thomas Leitner, Linos Vandekerckhove, Martin Däumer, Alexander Thielen, Bernd Buchholz, Andy I. M. Hoepelman, Elizabeth H. Gisolf, Pauline J. Schipper, Annemarie M. J. Wensing, Monique Nijhuis
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-13 (2018)
Abstract Background Emergence of resistance against integrase inhibitor raltegravir in human immunodeficiency virus type 1 (HIV-1) patients is generally associated with selection of one of three signature mutations: Y143C/R, Q148K/H/R or N155H, repre
Externí odkaz:
https://doaj.org/article/475a8646434341b186207350901f7945