Zobrazeno 1 - 10 of 163 pro vyhledávání: '"A. M. H. Brodie"'
3
Stopping treatment can reverse acquired resistance to letrozole
Autor: Angela M. H. Brodie, Luciana Macedo, Gauri Sabnis, Adam Schayowitz, Olga Goloubeva
Publikováno v: Cancer research. 68(12)
Using the intratumoral aromatase xenograft model, we have observed that despite long-lasting growth inhibition, tumors eventually begin to grow during continued letrozole treatment. In cells isolated from these long-term letrozole-treated tumors (LTL
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c0ed03197740d3112dec56bac55346
https://pubmed.ncbi.nlm.nih.gov/18559495
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4
The effect of tamoxifen on the pharmacokinetics of letrozole in female rats
Autor: I. P. Nnane, A. M. H. Brodie, X. Tao
Publikováno v: Biopharmaceuticsdrug disposition. 27(7)
The effects of single doses of tamoxifen (TAM; 0.5-5 mg/kg, i.v.) and chronic pretreatment with TAM (0.1-5.0 mg/kg/day, i.p. for 7 consecutive days) on letrozole (0.5 mg/kg, i.v.) pharmacokinetics were evaluated in female Sprague-Dawley rats. The pla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e00781b648b0a34446bfdecd208890
https://pubmed.ncbi.nlm.nih.gov/16912967
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5
Effects of exemestane and tamoxifen in a postmenopausal breast cancer model
Autor: James N. Ingle, Luciana Macedo, Danijela Jelovac, Brian J. Long, Venkatesh D. Handratta, Angela M. H. Brodie, Olga Goloubeva
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 10(21)
Purpose: To optimize treatment strategies for postmenopausal breast cancer patients, we investigated the efficacy of the steroidal aromatase inhibitor exemestane alone or in combination with the antiestrogen tamoxifen in a xenograft model of postmeno
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f687efb809ff42fd139eb74476e8f5
https://pubmed.ncbi.nlm.nih.gov/15534114
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8
Use of tissue-specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads
Autor: Serdar E. Bulun, S. E. Inkster, I. M. Rosenthal, W. P. Zeller, Evan R. Simpson, A. M. Digeorge, Michael W. Kilgore, S. D. Frasier, A. M. H. Brodie
Publikováno v: The Journal of clinical endocrinology and metabolism. 77(6)
We have previously demonstrated that the tissue-specific regulation of human aromatase cytochrome P450 (P450arom) gene expression is, in part, the consequence of the use of tissue-specific promoters. Promoter I.1 (PI.1) and PI.2-specific transcripts
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5928e94125a885fdf910781d4365d449
https://pubmed.ncbi.nlm.nih.gov/8106605
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9
Combination of HDACi entinostat (SNDX-275) with letrozole provides control over tumor growth in MDA-MB-231 xenograft model
Autor: Rabia A. Gilani, Vincent C. O. Njar, Olga Goloubeva, Angela M. H. Brodie, Lalji K. Gediya, Gauri Sabnis, Luciana Macedo
Publikováno v: Cancer Research. 69:6128
Abstract #6128 It is well established that approximately 75% of human breast cancers are ER+ and therefore treated with endocrine therapy. In a past few decades endocrine therapy has made significant advancements. However, the application of these ag
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0911e84a3df464f06baa90d09fe3253c
https://doi.org/10.1158/0008-5472.sabcs-6128
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10
Structure of 4-hydroxy-4-androstene-3,17-dione
Autor: J. F. Griffin, William L. Duax, A. M. H. Brodie, P. D. Strong, H. J. Brodie
Publikováno v: Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry. 36:201-203
C19H2603, P21212j, a = 18.540 (1), b = 24.348 (4), c = 7.3237 (6) A, V 3306.1 A 3, M r 302.41, Z = 8, D c = 1.22 Mg m-a; 3843 observations, 3114 > 2o¥. 4-Hydroxy-4-androstene-3,17-dione (4OH-A) is an effective inhibitor of estrogen synthetase and ha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e709d4ad4f62658b4de7625e9af7510
https://doi.org/10.1107/s0567740880002877
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