Zobrazeno 1 - 10
of 79
pro vyhledávání: '"A. M. Grin"'
Publikováno v:
Сельскохозяйственные машины и технологии, Vol 0, Iss 1, Pp 18-22 (2017)
Power consumption decrease is an important factor at the soil tillage and for the choice of working tools, in particular disc ones which are mounted on plow, harrow, disc headers, and stubblers. The authors have assumed that transformation of the ext
Externí odkaz:
https://doaj.org/article/21b46592feac4ae1b5440587e6255803
Autor:
Safiah H. C. Mai, Neha Sharma, Andrew C. Kwong, Dhruva J. Dwivedi, Momina Khan, Peter M. Grin, Alison E. Fox-Robichaud, Patricia C. Liaw
Publikováno v:
Intensive Care Medicine Experimental, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Background Despite increasing ethical standards for conducting animal research, death is still often used as an endpoint in mouse sepsis studies. Recently, the Murine Sepsis Score (MSS), Mouse Clinical Assessment Score for Sepsis (M-CASS), a
Externí odkaz:
https://doaj.org/article/973867c602074b8e8820923b794da362
Autor:
Luke S. Schembri, Susan A. Charman, Sheena McGowan, Georgina S. Butler, Christopher M. Overall, Jisook Lee, Wei Yang, Nyssa Drinkwater, Peter M. Grin, Peter J. Scammells, Natalie B. Vinh, Komagal Kannan Sivaraman, Michelle Gazdik
Publikováno v:
Journal of Medicinal Chemistry
Aminopeptidase N (APN/CD13) is a zinc-dependent M1 aminopeptidase that contributes to cancer progression by promoting angiogenesis, metastasis, and tumor invasion. We have previously identified hydroxamic acid-containing analogues that are potent inh
Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CL(pro) substrate degradome
Autor:
Jayachandran N. Kizhakkedathu, Peter M. Grin, Attila Szakos, Srinivas Abbina, Marli Vlok, Hugo C. Ramos de Jesus, Quynh T. Cao, Nestor Solis, Christopher M. Overall, Arinjay Banerjee, Cecilia Lindskog, Yasir Mohamud, Jenny P. Nguyen, Karen L. Mossman, Marcin Drag, Honglin Luo, Reinhild Kappelhoff, Laszlo Szekely, Isabel Pablos, John C. Vederas, Jeremy A. Hirota, Peter A. Bell, Wioletta Rut, Eric Jan, Georgina S. Butler, Yoan Machado
Publikováno v:
Cell Reports
The main viral protease (3CLpro) is indispensable for SARS-CoV-2 replication. We delineate the human protein substrate landscape of 3CLpro by TAILS substrate-targeted N-terminomics. We identify >100 substrates in human lung and kidney cells supported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2a499241c000d0c17afbe79f467089
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-459079
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-459079
Autor:
Patricia C. Liaw, Alison Fox-Robichaud, Bernardo L. Trigatti, Kevin M. Chathely, Dhruva J. Dwivedi, Nabil G. Seidah, Peter M. Grin, Annik Prat
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports
Scientific Reports
Lipoteichoic acid (LTA) and lipopolysaccharide (LPS) are bacterial lipids that stimulate pro-inflammatory cytokine production, thereby exacerbating sepsis pathophysiology. Proprotein convertase subtilisin/kexin type 9 (PCSK9) negatively regulates upt
Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases
Autor:
Sandra Duffy, Peter J. Scammells, Peter M. Grin, Tess R. Malcolm, Georgina S. Butler, Vicky M. Avery, Leonardo Lucantoni, Christopher M. Overall, Sheena McGowan, Natalie B. Vinh, Nyssa Drinkwater, Michael Kassiou
Publikováno v:
Journal of medicinal chemistry. 62(2)
There is an urgent clinical need for antimalarial compounds that target malaria caused by both Plasmodium falciparum and Plasmodium vivax. The M1 and M17 metalloexopeptidases play key roles in Plasmodium hemoglobin digestion and are validated drug ta
Publikováno v:
Russian Electrical Engineering. 87:140-144
Polyfunctional electromechanical energy transformers with a ferromagnetic rotor are considered that allow full use of dissipative energy and structural, functional, and thermal integration. The combination in one machine of several technological func
Autor:
A. M. Grin
Publikováno v:
University Management: Practice and Analysis. 104:15-27
Universities as higher education system institutions have their peculiarities in managing financial support, including absence of profit target, variety of activities, absence of tangible aspect in an educational product, regulation of using federal
Autor:
Patricia C. Liaw, Nicole Kraus, Matthew Berardocco, Amanda L. Patrick, Michelle Gold, Alison Fox-Robichaud, Peter M. Grin
Publikováno v:
Intensive Care Medicine Experimental
Background Fluid resuscitation is a crucial therapy for sepsis, and the use of balanced fluids and/or isotonic albumin may improve patient survival. We have previously demonstrated that resuscitation with normal saline results in increased hepatic le
Autor:
Patricia C. Liaw, Alison Fox-Robichaud, Ji Zhou, Annik Prat, Momina Khan, Dhruva J. Dwivedi, Nabil G. Seidah, Peter M. Grin
Publikováno v:
Shock (Augusta, Ga.). 46(6)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) targets lipoprotein receptors for degradation, thereby reducing hepatic lipid clearance. PCSK9 inhibition reduces mortality in septic mice, presumably through increased hepatic clearance of pathog