Zobrazeno 1 - 10
of 79
pro vyhledávání: '"A. M. Grin"'
Publikováno v:
Сельскохозяйственные машины и технологии, Vol 0, Iss 1, Pp 18-22 (2017)
Power consumption decrease is an important factor at the soil tillage and for the choice of working tools, in particular disc ones which are mounted on plow, harrow, disc headers, and stubblers. The authors have assumed that transformation of the ext
Externí odkaz:
https://doaj.org/article/21b46592feac4ae1b5440587e6255803
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract The release of cellular DNA as neutrophil extracellular traps (NETs) plays a pivotal role in the immune response to pathogens by physically entrapping and killing microbes. NET release occurs at a greater frequency within neutrophil clusters
Externí odkaz:
https://doaj.org/article/282aa1b896a543a6a72fed9f1609028c
Autor:
Safiah H. C. Mai, Neha Sharma, Andrew C. Kwong, Dhruva J. Dwivedi, Momina Khan, Peter M. Grin, Alison E. Fox-Robichaud, Patricia C. Liaw
Publikováno v:
Intensive Care Medicine Experimental, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Background Despite increasing ethical standards for conducting animal research, death is still often used as an endpoint in mouse sepsis studies. Recently, the Murine Sepsis Score (MSS), Mouse Clinical Assessment Score for Sepsis (M-CASS), a
Externí odkaz:
https://doaj.org/article/973867c602074b8e8820923b794da362
Autor:
Luke S. Schembri, Susan A. Charman, Sheena McGowan, Georgina S. Butler, Christopher M. Overall, Jisook Lee, Wei Yang, Nyssa Drinkwater, Peter M. Grin, Peter J. Scammells, Natalie B. Vinh, Komagal Kannan Sivaraman, Michelle Gazdik
Publikováno v:
Journal of Medicinal Chemistry
Aminopeptidase N (APN/CD13) is a zinc-dependent M1 aminopeptidase that contributes to cancer progression by promoting angiogenesis, metastasis, and tumor invasion. We have previously identified hydroxamic acid-containing analogues that are potent inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b723a9af1a55fe1412bad216fbc4b97
https://doi.org/10.1021/acs.jmedchem.9b00757
https://doi.org/10.1021/acs.jmedchem.9b00757
Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CL(pro) substrate degradome
Autor:
Jayachandran N. Kizhakkedathu, Peter M. Grin, Attila Szakos, Srinivas Abbina, Marli Vlok, Hugo C. Ramos de Jesus, Quynh T. Cao, Nestor Solis, Christopher M. Overall, Arinjay Banerjee, Cecilia Lindskog, Yasir Mohamud, Jenny P. Nguyen, Karen L. Mossman, Marcin Drag, Honglin Luo, Reinhild Kappelhoff, Laszlo Szekely, Isabel Pablos, John C. Vederas, Jeremy A. Hirota, Peter A. Bell, Wioletta Rut, Eric Jan, Georgina S. Butler, Yoan Machado
Publikováno v:
Cell Reports
The main viral protease (3CLpro) is indispensable for SARS-CoV-2 replication. We delineate the human protein substrate landscape of 3CLpro by TAILS substrate-targeted N-terminomics. We identify >100 substrates in human lung and kidney cells supported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2a499241c000d0c17afbe79f467089
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-459079
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-459079
Autor:
Patricia C. Liaw, Alison Fox-Robichaud, Bernardo L. Trigatti, Kevin M. Chathely, Dhruva J. Dwivedi, Nabil G. Seidah, Peter M. Grin, Annik Prat
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports
Scientific Reports
Lipoteichoic acid (LTA) and lipopolysaccharide (LPS) are bacterial lipids that stimulate pro-inflammatory cytokine production, thereby exacerbating sepsis pathophysiology. Proprotein convertase subtilisin/kexin type 9 (PCSK9) negatively regulates upt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eeae31ed44f66a5f000effd0a4fe241
http://link.springer.com/article/10.1038/s41598-018-28777-0
http://link.springer.com/article/10.1038/s41598-018-28777-0
Publikováno v:
Russian Electrical Engineering. 87:140-144
Polyfunctional electromechanical energy transformers with a ferromagnetic rotor are considered that allow full use of dissipative energy and structural, functional, and thermal integration. The combination in one machine of several technological func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81138a8509fdad51d8320085f27e52e4
https://doi.org/10.3103/s1068371216030123
https://doi.org/10.3103/s1068371216030123
Autor:
A. M. Grin
Publikováno v:
University Management: Practice and Analysis. 104:15-27
Universities as higher education system institutions have their peculiarities in managing financial support, including absence of profit target, variety of activities, absence of tangible aspect in an educational product, regulation of using federal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d0c8f9df5e48c02198867f874c380f7
https://doi.org/10.15826/umj.2016.103.024
https://doi.org/10.15826/umj.2016.103.024
Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases
Autor:
Sandra Duffy, Peter J. Scammells, Peter M. Grin, Tess R. Malcolm, Georgina S. Butler, Vicky M. Avery, Leonardo Lucantoni, Christopher M. Overall, Sheena McGowan, Natalie B. Vinh, Nyssa Drinkwater, Michael Kassiou
Publikováno v:
Journal of medicinal chemistry. 62(2)
There is an urgent clinical need for antimalarial compounds that target malaria caused by both Plasmodium falciparum and Plasmodium vivax. The M1 and M17 metalloexopeptidases play key roles in Plasmodium hemoglobin digestion and are validated drug ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faff4a86f36aed1cda068de548995257
https://pubmed.ncbi.nlm.nih.gov/30537832
https://pubmed.ncbi.nlm.nih.gov/30537832
Autor:
Patricia C. Liaw, Nicole Kraus, Matthew Berardocco, Amanda L. Patrick, Michelle Gold, Alison Fox-Robichaud, Peter M. Grin
Publikováno v:
Intensive Care Medicine Experimental
Background Fluid resuscitation is a crucial therapy for sepsis, and the use of balanced fluids and/or isotonic albumin may improve patient survival. We have previously demonstrated that resuscitation with normal saline results in increased hepatic le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d441f787811bd4a3e64b213be694641
http://europepmc.org/articles/PMC5247397
http://europepmc.org/articles/PMC5247397