Výsledky vyhledávání - "A. M. Goorin"

Intensified Chemotherapy With Dexrazoxane Cardioprotection in Newly Diagnosed Nonmetastatic Osteosarcoma: A Report From the Children's Oncology Group

Autor: Steven E. Lipshultz, Allen M. Goorin, Judith K. Sato, Laurel J. Steinherz, Cindy L. Schwartz, Mark L. Bernstein, Holcombe E. Grier, Lisa A. Teot, Paul A. Meyers, Mark Krailo, Mark C. Gebhardt, Leonard H. Wexler, Meenakshi Devidas, John H. Healey

Publikováno v: Pediatric Blood & Cancer. 63:54-61

Background Although chemotherapy has improved outcome of osteosarcoma, 30–40% of patients succumb to this disease. Survivors experience substantial morbidity and mortality from anthracycline-induced cardiotoxicity. We hypothesized that the cardiopr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14e32ff5353c72f1b711fce324476317
https://doi.org/10.1002/pbc.25753

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Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study

Autor: Leonard H. Wexler, Cindy L. Schwartz, Allen M. Goorin, Richard Gorlick, Jeffrey A. Toretsky, Mark L. Bernstein, Donald A. Barkauskas, Scott C. Borinstein, Mark Krailo

Publikováno v: Pediatric Blood & Cancer. 61:749-752

To investigate the role of insulin-like growth factor-1 (IGF-1), in localized osteosarcoma, serum levels of IGF-1, IGFBP-2, and IGFBP-3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30cf6494cd1334bc865590a10054ac2f
https://doi.org/10.1002/pbc.24778

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Multiple Drug Resistance in Osteogenic Sarcoma: INT0133 From the Children's Oncology Group

Autor: Cindy L. Schwartz, Paul A. Meyers, Allen M. Goorin, Mark L. Bernstein, Zhengjia Chen, Lisa A. Teot, Mark Krailo, Richard Gorlick, Holcombe E. Grier

Publikováno v: Journal of Clinical Oncology. 25:2057-2062

Purpose Multiple drug resistance due to P-glycoprotein (P-gp) expression has been reported to be a cause of disease recurrence in osteosarcoma. Tumor specimens derived from children and young adults with osteosarcoma enrolled onto a national Intergro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28084be0140bc6307c72f2edbf26eb83
https://doi.org/10.1200/jco.2006.07.7776

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Intensified Chemotherapy With Dexrazoxane Cardioprotection in Newly Diagnosed Nonmetastatic Osteosarcoma: A Report From the Children's Oncology Group

Autor: Cindy L, Schwartz, Leonard H, Wexler, Mark D, Krailo, Lisa A, Teot, Meenakshi, Devidas, Laurel J, Steinherz, Allen M, Goorin, Mark C, Gebhardt, John H, Healey, Judith K, Sato, Paul A, Meyers, Holcombe E, Grier, Mark L, Bernstein, Steven E, Lipshultz

Publikováno v: Pediatric bloodcancer. 63(1)

Although chemotherapy has improved outcome of osteosarcoma, 30-40% of patients succumb to this disease. Survivors experience substantial morbidity and mortality from anthracycline-induced cardiotoxicity. We hypothesized that the cardioprotectant dexr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a5a5fd3481f6b97f32a4bcef7f6d5a3
https://pubmed.ncbi.nlm.nih.gov/26398490

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Phase II study of ecteinascidin 743 in heavily pretreated patients with recurrent osteosarcoma

Autor: Caroline Laverdiere, Ana Ruiz-Casado, Jose Jimeno, Andrew G. Huvos, Allen M. Goorin, Leonard Wexler, Richard Gorlick, George D. Demetri, Robert G. Maki, Jeffrey G. Supko, David Harmon, E. Anders Kolb, Paul A. Meyers, Cecilia Guzman, John H. Healey, Rochelle Bagatell

Publikováno v: Cancer. 98:832-840

BACKGROUND Recurrent osteosarcoma is a drug-resistant disease with a dismal prognosis. The objective of this Phase II study was to evaluate the activity of ecteinascidin 743 (ET-743) as a salvage therapy in these patients. METHODS Patients with recur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5b398d1429fd11d415fffb8a0de68f
https://doi.org/10.1002/cncr.11563

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Presurgical Chemotherapy Compared With Immediate Surgery and Adjuvant Chemotherapy for Nonmetastatic Osteosarcoma: Pediatric Oncology Group Study POG-8651

Autor: Michael E. Harris, Lee J. Helman, Holcombe E. Grier, Meenakshi Devidas, Mark C. Gebhardt, Michael P. Link, Alberto G. Ayala, Allen M. Goorin, Douglas J. Schwartzentruber

Publikováno v: Journal of Clinical Oncology. 21:1574-1580

Purpose: Successful therapeutic interventions to prevent disease progression in patients with nonmetastatic osteosarcoma have included surgery with adjuvant chemotherapy. Presurgical chemotherapy has been advocated for these patients because of putat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0e5c51d60a0a484c40ae0267a3b12b
https://doi.org/10.1200/jco.2003.08.165

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Phase II/III Trial of Etoposide and High-Dose Ifosfamide in Newly Diagnosed Metastatic Osteosarcoma: A Pediatric Oncology Group Trial

Autor: Allen M, Goorin, Michael B, Harris, Mark, Bernstein, William, Ferguson, Meenakshi, Devidas, Gene P, Siegal, Mark C, Gebhardt, Cindy L, Schwartz, Michael, Link, Holcombe E, Grier

Publikováno v: Journal of Clinical Oncology. 20:426-433

PURPOSE: The objectives of this trial were to estimate the response rate, progression-free survival, and overall survival of patients who received therapy with etoposide and high-dose ifosfamide, and to define the toxicity of this combination when pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d400cb5aa20cb2c38d19aa4389f1b5
https://doi.org/10.1200/jco.2002.20.2.426

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