Zobrazeno 1 - 10
of 149
pro vyhledávání: '"A. M. Gilfillan"'
Publikováno v:
European Journal of Immunology. 43:1873-1882
Following antigen/IgE-mediated aggregation of high affinity IgE-receptors (FceRI), mast cells (MCs) degranulate and release inflammatory mediators leading to the induction of allergic reactions including anaphylaxis. Migration of MCs to resident tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc9295cae6e7db28310fac717c434266
https://doi.org/10.1002/eji.201243214
https://doi.org/10.1002/eji.201243214
Autor:
I. Ashmole, Peter Bradding, Michael A. Beaven, Alasdair M. Gilfillan, Dean D. Metcalfe, Glenn Cruse
Publikováno v:
Immunity. 38:906-917
SummaryHuman linkage analyses have implicated the MS4A2-containing gene locus (encoding FcεRIβ) as a candidate for allergy susceptibility. We have identified a truncation of FcεRIβ (t-FcεRIβ) in humans that contains a putative calmodulin-bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc55bbdbe8e6ab9885fee08e7bcf243f
https://doi.org/10.1016/j.immuni.2013.04.007
https://doi.org/10.1016/j.immuni.2013.04.007
Autor:
Jeong Han Kang, Shoko Iwaki, Marcus V. Andrade, Alasdair M. Gilfillan, Jared M. Brown, Daniel Smrž, Susana C. Hilderbrand, Tomonobu Ito, Avanti Desai, Dean D. Metcalfe, Mi-Yeon Jung, Geethani Bandara, Michael A. Beaven
Publikováno v:
The Journal of Immunology. 190:531-538
IL-33 is elevated in afflicted tissues of patients with mast cell (MC)–dependent chronic allergic diseases. Based on its acute effects on mouse MCs, IL-33 is thought to play a role in the pathogenesis of allergic disease through MC activation. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0250d194c3fc1948513a0dd730105dbb
https://doi.org/10.4049/jimmunol.1201576
https://doi.org/10.4049/jimmunol.1201576
Autor:
Dean D. Metcalfe, E Ching Chan, Alasdair M. Gilfillan, D L Flynn, Olga Simakova, Todd M. Wilson, S N Bandara, Yun Bai, Geethani Bandara, W.P. Lu, Irina Maric, Scott C. Wise
Publikováno v:
Leukemia
Activating mutations in the receptor tyrosine kinase KIT, most notably KIT D816V, are commonly observed in patients with systemic mastocytosis. Thus, inhibition of KIT has been a major focus for treatment of this disorder. Here we investigated a nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979bd859489f071be5ae210e565f3d95
https://doi.org/10.1038/leu.2012.218
https://doi.org/10.1038/leu.2012.218
Autor:
Avanti Desai, Šárka Smržová, Mi-Yeon Jung, Geethani Bandara, Alasdair M. Gilfillan, Michael A. Beaven, Daniel Smrž, Dean D. Metcalfe, Tomonobu Ito, Hye Sun Kuehn
Publikováno v:
The Journal of Immunology. 188:5428-5437
Mast cells, activated by Ag via FcεRI, release an array of proinflammatory mediators that contribute to allergic disorders, such as asthma and anaphylaxis. The KIT ligand, stem cell factor (SCF), is critical for mast cell expansion, differentiation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76eb9b1d5713fa6a9e3bf72fac6a7a7d
https://doi.org/10.4049/jimmunol.1103366
https://doi.org/10.4049/jimmunol.1103366
Autor:
Joan Sayós, Damiana Álvarez-Errico, Erola Ainsua-Enrich, Margarita Martin, César Picado, Irene Oliver-Vila, Alasdair M. Gilfillan
Publikováno v:
The Journal of Immunology. 187:5577-5586
CD84 is a self-binding receptor from the CD150 (or signaling lymphocyte activation molecule [SLAM]) family that is broadly expressed in hematopoietic cells. It has been described that the adaptors SLAM-associated protein (SAP) and EWS-FLI1–activate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7cc613a67c43898c94277ecb3caedc
https://doi.org/10.4049/jimmunol.1101626
https://doi.org/10.4049/jimmunol.1101626
Autor:
Aaron B. Bowen, Kimberly D. Dyer, Tomonobu Ito, Karin E. Peterson, Katia E. Garcia-Crespo, Helene F. Rosenberg, Caroline M. Percopo, Alasdair M. Gilfillan
Publikováno v:
Journal of Leukocyte Biology. 90:1101-1109
We examine the proliferation and differentiation of bone marrow (BM) progenitors from inbred Rocky Mountain White (IRW) mice, a strain used primarily for retrovirus infection studies. In contrast to findings with BALB/c and C57BL/6 strains, IRW BM ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331e68fb3490f2cf259ad149e90fbd82
https://doi.org/10.1189/jlb.0211059
https://doi.org/10.1189/jlb.0211059
Publikováno v:
Journal of Biological Chemistry. 286:391-402
Prostaglandin (PG) E(2), a potent mediator produced in inflamed tissues, can substantially influence mast cell responses including adhesion to basement membrane proteins, chemotaxis, and chemokine production. However, the signaling pathways by which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad5987fb6b10cfedb162bc5588ce822
https://doi.org/10.1074/jbc.m110.164772
https://doi.org/10.1074/jbc.m110.164772
Publikováno v:
Critical Reviews™ in Immunology. 31:475-530
Mast cells are multifunctional cells that initiate not only IgE-dependent allergic diseases but also play a fundamental role in innate and adaptive immune responses to microbial infection. They are also thought to play a role in angiogenesis, tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef49ecbcdc61f071755b511127d01c19
https://doi.org/10.1615/critrevimmunol.v31.i6.30
https://doi.org/10.1615/critrevimmunol.v31.i6.30
Publikováno v:
European Journal of Immunology. 40:3557-3569
TLR, expressed on the surface of mast cells, respond to a variety of bacterial and viral components to induce and enhance high-affinity IgE receptor-mediated cytokine production. Recent reports have indicated that specific TLR-dependent responses in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc67c72fd1a07cc7d7304eee42c34b11
https://doi.org/10.1002/eji.201040573
https://doi.org/10.1002/eji.201040573